Psychological therapies are used widely in liaison mental health settings to treat individuals with a variety of different mental health problems. The three most common clinical problem areas, however, are persistent physical symptoms (PPS), depression/anxiety associated with physical disease and self-harm. There is a relatively strong evidence base for treatments which target PPS, albeit with certain caveats, whereas the evidence for co-morbid depression/anxiety is quite weak. Psychological treatments for self-harm are discussed in Chapter 5. The most common psychological intervention is cognitive behavioural therapy (CBT), for which there is a large evidence base. There is, however, no clear evidence that CBT is superior to most other bona fide therapies which are currently delivered in a National Health Service (NHS) setting.