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Chapter 2 - Psychiatric Drug Discovery and Development

from Part 1 - Basic Science and General Principles

Published online by Cambridge University Press:  29 May 2020

By
Mohammed Shahid ,
Joanna C. Neill  and
John Hutchison
Edited by
Peter M. Haddad  and
David J. Nutt
Peter M. Haddad
Affiliation:
Hamad Medical Corporation, Qatar
David J. Nutt
Affiliation:
Centre for Neuropsychopharmacology, Division of Psychiatry, Department of Brain Sciences, Imperial College London
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Summary

This chapter reviews the process of psychiatric drug discovery and development. People suffering from mental illness need better drugs with improved efficacy and reduced side-effect burden than those currently available. The aim of drug discovery and development in this area is to manage illness, improve quality of life, and to reduce burden on carers and on the economy. Long-term disability associated with incomplete treatment response profoundly compromises the ability of affected individuals to function properly and significantly reduces their quality of life. This in turn has societal consequences in terms of the cost burden associated with the high prevalence of psychiatric disorders. Brain disorders cost €141 billion per annum in the UK, with a total 2010 cost (in million € purchasing power parity) of psychotic disorders of €16 717 (Fineberg et al., 2013).

Type
Chapter
Information
Seminars in Clinical Psychopharmacology , pp. 35 - 68
Publisher: Cambridge University Press
Print publication year: 2020

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