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2 - Formation of the eye field

Published online by Cambridge University Press:  22 August 2009

By
Michael E. Zuber  and
William A. Harris
Edited by
Evelyne Sernagor ,
Stephen Eglen ,
Bill Harris  and
Rachel Wong
Michael E. Zuber
Affiliation:
Department of Ophthalmology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
William A. Harris
Affiliation:
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Evelyne Sernagor
Affiliation:
University of Newcastle upon Tyne
Stephen Eglen
Affiliation:
University of Cambridge
Bill Harris
Affiliation:
University of Cambridge
Rachel Wong
Affiliation:
Washington University, St Louis
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Summary

Introduction

Vertebrate eyes originate from a single field of neuroectodermal cells in the anterior region of the neural plate called the eye field (sometimes referred to as the eye anlage, eye primordia or presumptive eye). The origins of the eye field can be traced back to the 32-cell-stage blastula in which a subset of blastomeres is competent, but not yet committed, to form retina. This chapter begins with a discussion of retinal competence and the maternal molecules and cell–cell interactions that take place in and bias early blastomeres toward a retinal fate. Transplantation experiments have shown that the entire presumptive neural plate of midgastrula embryos can form retina, demonstrating the remarkable coordination of neural development with eye formation. Neural induction and the neural patterning events critical for defining where the eye field forms in the developing nervous system will be addressed. Cultured amphibian anterior neural plates form eyes demonstrating that the eye field is specified (committed to form the eye) by the neural plate stage. A conserved set of transcription factors collectively referred to as eye field transcription factors are required for normal eye formation and are expressed in the eye field of the neural plate stage embryo. These genes and their functional interactions, which are required for and under some circumstances sufficient to drive eye field and eye formation will be described. A description of how the single vertebrate eye field separates to form the eye primordia that eventually give rise to the two eyes concludes this chapter.

Type
Chapter
Information
Retinal Development , pp. 8 - 29
Publisher: Cambridge University Press
Print publication year: 2006

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  • Formation of the eye field
    • By Michael E. Zuber, Department of Ophthalmology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA, William A. Harris, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
  • Edited by Evelyne Sernagor, University of Newcastle upon Tyne, Stephen Eglen, University of Cambridge, Bill Harris, University of Cambridge, Rachel Wong, Washington University, St Louis
  • Book: Retinal Development
  • Online publication: 22 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541629.004
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  • Formation of the eye field
    • By Michael E. Zuber, Department of Ophthalmology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA, William A. Harris, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
  • Edited by Evelyne Sernagor, University of Newcastle upon Tyne, Stephen Eglen, University of Cambridge, Bill Harris, University of Cambridge, Rachel Wong, Washington University, St Louis
  • Book: Retinal Development
  • Online publication: 22 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541629.004
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Formation of the eye field
    • By Michael E. Zuber, Department of Ophthalmology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA, William A. Harris, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
  • Edited by Evelyne Sernagor, University of Newcastle upon Tyne, Stephen Eglen, University of Cambridge, Bill Harris, University of Cambridge, Rachel Wong, Washington University, St Louis
  • Book: Retinal Development
  • Online publication: 22 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541629.004
Available formats
×