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13 - Pontomedullary mediated REM-sleep atonia

from Section III - Neuronal regulation

Published online by Cambridge University Press:  07 September 2011

By
Yuan-Yang Lai  and
Jerome M. Siegel
Edited by
Birendra N. Mallick ,
S. R. Pandi-Perumal ,
Robert W. McCarley  and
Adrian R. Morrison
Yuan-Yang Lai
Affiliation:
VAGLAHS Sepulveda, USA
Jerome M. Siegel
Affiliation:
VAGLAHS Sepulveda, USA
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
S. R. Pandi-Perumal
Affiliation:
Somnogen Canada Inc, Toronto
Robert W. McCarley
Affiliation:
Harvard University, Massachusetts
Adrian R. Morrison
Affiliation:
University of Pennsylvania
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Summary

Summary

The medial pontomedullary reticular formation has been implicated in the control of motor activity in REM sleep. Electrical stimulation of points within this area elicits global inhibition of skeletal motor activity in decerebrate animals. This area can be segregated into four distinct subregions based on the response to chemical stimulation. Injection of glutamate, acetylcholine, and corticotropin-releasing factor into the medial pons, the pontine inhibitory area, induces muscle atonia. In the medial medulla, the nucleus magnocellularis (NMC) of the rostroventral medulla responds to glutamate and corticotropin-releasing factor and the nucleus paramedianus of the caudomedial medulla responds to acetylcholine injection, with suppression of muscle tone being induced by these chemicals. In contrast, the transmitter involved in elicitation of atonia by electrical stimulation of the nucleus gigantocellularis of the dorsomedial medulla is unclear. Lesions in this area increase phasic and tonic muscle activity in REM sleep in the chronic animal. Our recent study found that an area rostral to the pons, located at the ventral portion of the junction of the midbrain and pons, the ventral mesopontine junction (VMPJ), is also involved in the control of muscle activity in sleep. Neurotoxic lesions of the VMPJ produce periodic leg movements in slow-wave sleep and increase phasic and tonic muscle activity in REM sleep in the cat, symptoms resembling the human REM sleep behavior disorder (RBD). The anatomical proximity of the VMPJ and the substantia nigra may thus provide a link between RBD and Parkinsonism.

Type
Chapter
Information
Rapid Eye Movement Sleep
Regulation and Function
 , pp. 121 - 129
Publisher: Cambridge University Press
Print publication year: 2011

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References

Brooks, P. L. & Peever, J. H. (2008) Glycinergic and GABAA-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia. J Neurosci 28: –45.CrossRefGoogle Scholar
Chase, M. H., Morales, F. R., Boxer, P. A., Fung, S. J. & Soja, P. (1986) Effect of stimulation of the nucleus reticularis gigantocellularis on the membrane potential of cat lumbar motoneurons during sleep and wakefulness. Brain Res 386: –44.CrossRefGoogle ScholarPubMed
D’Ascanio, P., Pompeiano, O. & Tononi, G. (1989) Inhibition of vestibulospinal reflexes during the episodes of postural atonia induced by unilateral lesion of the locus coeruleus in the decerebrate cat. Arch Ital Biol 127: –97.Google ScholarPubMed
Engberg, I., Lundberg, A. & Ryall, R. W. (1968) Reticulospinal inhibition of transmission in reflex pathways. J Physiol 194: –23.CrossRefGoogle ScholarPubMed
Fung, S. J. & Barnes, C. D. (1989) Raphe-produced excitation of spinal cord motoneurons in the cat. Neurosci Lett 103: –90.CrossRefGoogle ScholarPubMed
Gall, A. J., Poremba, A. & Blumberg, M. S. (2007) Brainstem cholinergic modulation of muscle tone in infant rats. Eur J Neurosci 253: –75.Google Scholar
Gallager, D. W. & Pert, A. (1978) Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase. Brain Res 144: –75.CrossRefGoogle ScholarPubMed
George, R., Haslett, W. L. & Jenden, D. J. (1964). A cholinergic mechanism in the brainstem reticular formation: induction of paradoxical sleep. Int J Neuropharmacol 3: –52.CrossRefGoogle ScholarPubMed
Hajnik, T., Lai, Y. Y. & Siegel, J. M. (2000). Atonia-related regions in the rodent pons and medulla. J Neurophysiol 84: –8.CrossRefGoogle ScholarPubMed
Hendricks, J. C., Morrison, A. R. & Mann, G. L. (1982) Different behaviors during paradoxical sleep without atonia depend on pontine lesion site. Brain Res 239: –105.CrossRefGoogle ScholarPubMed
Holmes, C. J. & Jones, B. E. (1994) Importance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleep–wake states studied by cytotoxic lesions in the cat. Neuroscience 62: –200.Google ScholarPubMed
Holstege, J. C. (1991) Ultrastructure evidence for GABAergic brain stem projections to spinal motoneurons in the rat. J Neurosci 11: –67.CrossRefGoogle ScholarPubMed
Hoshino, K. & Pompeiano, O. (1976) Selective discharge of pontine neurons during the postural atonia produced by an anticholinesterase in the decerebrate cat. Arch Ital Biol 114: –7.Google ScholarPubMed
Jelev, A., Sood, S., Liu, H., Nolan, P. & Horner, R. L. (2001) Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J Physiol 532: –81.CrossRefGoogle ScholarPubMed
Jouvet, M. & Mounier, D. (1960) Effects des lesions de la formation reticule pontique sur le sommeil du chat. C R Soc. de Biol 154: –5.Google Scholar
Kanamori, N., Sakai, K. & Jouvet, M. (1980) Neuronal activity specific to paradoxical sleep in the ventromedial medullary reticular formation of unrestrained cats. Brain Res 189: –5.CrossRefGoogle Scholar
Kausz, M. (1991) Arrangement of neurons in the medullary reticular formation and raphe nuclei projecting to thoracic, lumbar and sacral segments of the spinal cord in the cat. Anat Embryol 183: –63.CrossRefGoogle ScholarPubMed
Kodama, T., Lai, Y. Y. & Siegel, J. M. (2003) Changes in inhibitory amino acid release linked to pontine-induced atonia: anin vivo microdialysis study. 23: –54.Google Scholar
Kohyama, J., Lai, Y. Y. & Siegel, J. M. (1998) Reticulospinal systems mediate atonia with short and long latencies. J Neurophysiol 80: –51.CrossRefGoogle Scholar
Lai, Y. Y. & Siegel, J. M. (1988) Medullary regions regulating atonia. J Neurosci 8: –6.CrossRefGoogle Scholar
Lai, Y. Y. & Siegel, J. M. (1990) Muscle tone suppression and stepping produced by stimulation of the midbrain and rostral pontine reticular formation. J Neurosci 10: –38.CrossRefGoogle ScholarPubMed
Lai, Y. Y. & Siegel, J. M. (1991) Pontomedullary glutamate receptors mediating locomotion and muscle tone suppression. J Neurosci 11: –7.CrossRefGoogle ScholarPubMed
Lai, Y. Y., Siegel, J. M. & Wilson, W. J. (1987) Effect of blood pressure on medial medulla-induced muscle atonia. Am J Physiol 252, –57.Google ScholarPubMed
Lai, Y. Y., Strahlendorf, H. K., Fung, S. J. & Barnes, C. D. (1989) The actions of two monoamines on spinal motoneurons from stimulation of the locus coeruleus. Brain Res 484: –72.CrossRefGoogle ScholarPubMed
Lai, Y. Y., Clements, J. R. & Siegel, J. M. (1993) Glutamatergic and cholinergic projections to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry. J Comp Neurol 336: –30.CrossRefGoogle ScholarPubMed
Lai, Y. Y., Clements, J. R., Wu, X. Y. . (1999) Brainstem projections to the ventromedial medulla in cat: retrograde transport horseradish peroxidase and immunohistochemical studies. J Comp Neurol 408: –36.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Lai, Y. Y., Kodama, T. & Siegel, J. M. (2001) Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: anin vivo microdialysis study. 21: –91.Google Scholar
Lai, Y. Y., Hsieh, K. C., Nguyen, D., Peever, J. & Siegel, J. M. (2008) Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep. Neuroscience 154: –43.CrossRefGoogle ScholarPubMed
Magoun, H. W. & Rhines, R. (1946) An inhibitory mechanism in the bulbar reticular formation. J Neurophysiol 9: –71.CrossRefGoogle ScholarPubMed
Matsuyama, K., Mori, F., Kuze, B. & Mori, S. (1999). Morphology of single pontine reticulospinal axons in the lumbar enlargement of the cat: a study using anterograde tracer PHA-L. J Comp Neurol 410: –30.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Mazza, S., Soucy, J., Gravel, P. . (2006) Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. Neurology 67: –22.CrossRefGoogle ScholarPubMed
Mileykovskiy, B. Y., Kiyashchenko, L. I., Kodama, T., Lai, Y. Y. & Siegel, J. M. (2000) Activation of pontine and medullary motor inhibitory regions reduces discharge in neurons located in the locus coeruleus and the anatomical equivalent of the midbrain locomotor region. J Neurosci 20: –8.CrossRefGoogle ScholarPubMed
Onoe, H. & Sakai, K. (1995) Kainate receptors: a novel mechanism in paradoxical (REM) sleep generation. NeuroReport 6: –6.Google ScholarPubMed
Pompeiano, O., D’Ascanio, P., Horn, E. & Stampacchia, G. (1987) Effects of local injection of the α2-adrenergic agonist clonidine into the locus coeruleus complex on the gain of vestibulospinal and cervicospinal reflexes in decerebrate cats. Arch Ital Biol 125: –89.Google Scholar
Reinoso-Suarez, F., De Andres, I., Rodrigo-Angulo, M. L. & Rodriguez-Veiga, E. (1994) Location and anatomical connections of a paradoxical sleep induction site in the cat ventral pontine tegmentum. Eur J Neurosci 6: –36.CrossRefGoogle ScholarPubMed
Schenck, C. H. & Mahowald, M. W. (1990) Polysomnographic, neurologic, psychiatric, and clinical outcome report on 70 consecutive cases with REM sleep behavior disorder (RBD): sustained clonazepam efficacy in 89.5% of 57 treated patients. Cleveland Clin J Med 37: Suppl, –23.Google Scholar
Schenkel, E., & Siegel, J. M. (1989) REM sleep without atonia after lesions of the medial medulla. Neurosci Lett 98: –65.CrossRefGoogle ScholarPubMed
Shiromani, P. J., Lai, Y. Y. & Siegel, J. M. (1990) Descending projections from the dorsolateral pontine tegmentum to the paramedian reticular nucleus of the caudal medulla in the cat. Brain Res 517: –8.CrossRefGoogle ScholarPubMed
Shouse, M. N. & Siegel, J. M. (1992) Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep. Brain Res 571: –63.CrossRefGoogle ScholarPubMed
Soja, P. J., Morales, F. R., Baranyi, A. & Chase, M. H. (1987) Effect of inhibitory amino acid antagonists on IPSPs induced in lumbar motoneurons upon stimulation of the nucleus reticularis gigantocellularis during active sleep. Brain Res 423: –8.CrossRefGoogle ScholarPubMed
Takakusaki, K., Kohyama, J. & Matsuyama, K. (2001) Medullary reticulospinal tract mediating the generalized motor inhibition in cats: parallel inhibitory mechanisms acting on motoneurons and on interneuronal transmission in reflex pathways. Neuroscience 103: –27.CrossRefGoogle ScholarPubMed
Van Dongen, P. A. M., Broekkamp, C. L. E. & Cools, A. R. (1978) Atonia after carbachol microinjections near the locus coeruleus in cats. Pharmacol Biochem Behav 8: –32.CrossRefGoogle ScholarPubMed

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