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from Section 5 - Antepartum (Infectious Complications)
Published online by Cambridge University Press: 08 April 2025
The most common viral cause of congenital infection is CMV, a double-stranded DNA herpesvirus, affecting 0.2–2.2% of all neonates. It is the leading nongenetic cause of congenital deafness and a major cause of neurologic disability in children. Of previously seronegative women, 1–4% will become infected during pregnancy, and while most are asymptomatic, some patients may experience a mononucleosis-like syndrome. The diagnosis of primary CMV infection in pregnancy can be made by IgG seroconversion or detection of CMV IgM and IgG antibodies and low IgG avidity. Routine serologic screening of pregnant women for CMV is not recommended. Pregnant patients, particularly those who care for young children, should be counseled about behavioral measures to reduce the risk of CMV infection.
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