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Chapter 14 - Reproductive Toxicology

Published online by Cambridge University Press:  16 February 2022

David Mortimer ,
Lars Björndahl ,
Christopher L. R. Barratt ,
José Antonio Castilla ,
Roelof Menkveld ,
Ulrik Kvist ,
Juan G. Alvarez  and
Trine B. Haugen
David Mortimer
Affiliation:
Oozoa Biomedical Inc., Vancouver
Lars Björndahl
Affiliation:
Karolinska Institutet, Stockholm
Christopher L. R. Barratt
Affiliation:
University of Dundee
José Antonio Castilla
Affiliation:
HU Virgen de las Nieves, Granada
Roelof Menkveld
Affiliation:
Stellenbosch University, South Africa
Ulrik Kvist
Affiliation:
Karolinska Institutet, Stockholm
Juan G. Alvarez
Affiliation:
Centro ANDROGEN, La Coruña
Trine B. Haugen
Affiliation:
Oslo Metropolitan University
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Summary

This short chapter focusses on studies of semen quality, particularly the standardization of methods, the need for training of technicians, and study design.

Keywords

reproductive toxicologystudy designtraining
Type
Chapter
Information
A Practical Guide to Basic Laboratory Andrology , pp. 303 - 306
Publisher: Cambridge University Press
Print publication year: 2022

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References

Pizzol, D, Foresta, C, Garolla, A. Pollutants and sperm quality: a systematic review and meta-analysis. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-020-11589-zGoogle Scholar
Semet, M, Paci, M, Saïas-Magnan, J, et al. The impact of drugs on male fertility: a review. Andrology 2017; 5: 640–63.Google Scholar
Mortimer, D, Barratt, CL, Björndahl, L, et al. What should it take to describe a substance or product as ‘sperm-safe’. Hum Reprod Update 2013; 19 Suppl 1: i1–45.CrossRefGoogle ScholarPubMed
Arzuaga, X, Smith, MT, Catherine, F Gibbons, CF, et al. Proposed key characteristics of male reproductive toxicants as an approach for organizing and evaluating mechanistic evidence in human health hazard assessments. Environ Health Perspect 2019; 127: 65001.Google Scholar
Rahban, R, Nef, S. Regional difference in semen quality of young men: a review on the implication of environmental and lifestyle factors during fetal life and adulthood. Basic Clin Androl 2020; 30: 16. https://doi.org/10.1186/s12610-020-00114-4Google Scholar
Virtanen, HE, Jørgensen, N, Toppari, J. Semen quality in the 21st century. Nat Rev Urol 2017; 14: 120–30.Google Scholar
Sánchez Pozo, C, Mendiola, J, Serrano, M, et al. Proposal of guidelines for the appraisal of SEMen QUAlity studies (SEMQUA). Hum Reprod 2013; 28: 10–21.CrossRefGoogle ScholarPubMed
Björndahl, L, Barratt, CL, Mortimer, D, Jouannet, P. ‘How to count sperm properly’: checklist for acceptability of studies based on human semen analysis. Hum Reprod 2016; 31: 227–32.Google Scholar
Brazil, C, Shanna, SH, Tollner, CR, et al. Study for Future Families Research Group. Quality control of laboratory methods for semen evaluation in a multicenter research study. J Androl 2004; 25: 645–56.Google Scholar
Cooper, TG, Brazil, C, Swan, SH, Overstreet, JW. Ejaculate volume is seriously underestimated when semen is pipetted or decanted into cylinders from the collection vessel. J Androl 2007; 28: 1–4.Google Scholar
Douglas-Hamilton, DH, Smith, NG, Kuster, CE, et al. Capillary-loaded particle fluid dynamics: effect on estimation of sperm concentration. J Androl 2005; 26: 115–22.Google Scholar
Stokes-Riner, A, Thurston, SW, Brazil, C, et al. One semen sample or 2? Insights from a study of fertile men. J Androl 2007; 28: 38–43.Google Scholar
Rylander, L, Wetterstrand, B, Haugen, TB. Single semen analysis as a predictor of semen quality: clinical and epidemiological implications. Asian J Androl 2009; 11: 723–30.Google Scholar
Auger, J, Eustache, F, Ducot, B, et al. Intra- and inter-individual variability in human sperm concentration, motility and vitality assessment during a workshop involving ten laboratories. Hum Reprod 2000; 15: 2360–8.Google Scholar
Björndahl, L, Barratt, CL, Fraser, LR, et al. ESHRE basic semen analysis courses 1995–1999: immediate beneficial effects of standardized training. Hum Reprod 2002; 17: 1299–305.Google Scholar

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