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Chapter 43 - Chimeric Antigen Receptor (CAR) T-Cell Toxicity

from Section 5 - Lymphatic System

Published online by Cambridge University Press:  10 August 2023

Monica Kathleen Wattana
Monica Kathleen Wattana
Affiliation:
University of Texas, MD Anderson Cancer Center
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Summary

Overview of toxicities related to immunotherapy agents, and other complications in the lymphatic system such as tumor lysis, hyperviscosity syndrome, graft vs host disease, and neutropenic fever

Keywords

tumor lysisacute leukemianeutropenic feverdifferentiation syndrome
Type
Chapter
Information
Pocket Guide to Oncologic Emergencies , pp. 173 - 176
Publisher: Cambridge University Press
Print publication year: 2023

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References

Garcia Borrega, J, Gödel, P, Rüger, MA, Onur, OA, Shimabukuro-Vornhagen, A, Kochanek, M, Böll, B. In the eye of the storm: Immune-mediated toxicities associated with CAR-T cell therapy. HemaSphere. 2019;3(2):e191. 29. Doi: 10.1097/HS9.0000000000000191.CrossRefGoogle ScholarPubMed
Neelapu, SS. Managing the toxicities of CAR T-cell therapy. Hematological Oncology. 2019;37(S1): 48–52. Doi: 10.1002/hon.2595.CrossRefGoogle ScholarPubMed
Riegler, LL, Jones, GP, Lee, DW. Current approaches in the grading and management of cytokine release syndrome after chimeric antigen receptor T-cell therapy. Therapeutics and Clinical Risk Management. 2019;15:323‒335. Doi: 10.2147/TCRM.S150524.CrossRefGoogle ScholarPubMed
Sheth, VS, Gauthier, J. Taming the beast: CRS and ICANS after CAR T-cell therapy for ALL. Bone Marrow Transplant. 2021; 56:552–566. Doi: 10.1038/s41409-020-01134-4.CrossRefGoogle ScholarPubMed

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