This chapter surveys the rapid growth of globe-spanning organizations and institutions over the past 120 years – from the League of Nations to the UN to today’s International Criminal Court and European Union. Spurred by the world wars, economic crises, and environmental disasters of the twentieth century, humanity has already come much farther than most people realize in building innovative instruments of global concertation and crisis management. Therefore, the pathways of constructive change that lie ahead of us can best be understood as continuations and extensions of the remarkable gains already achieved. Four institutions – OECD, UN, NATO, and EU – exemplify distinct levels of rising integration across national boundaries. Institutions such as International Non-Governmental Organizations (INGOs) have offered powerful new pathways for citizens’ concerted action beyond borders. The recently-adopted UN doctrine of Responsibility to Protect (R2P) reflects a newfound legitimacy of cross-border ethical obligations and proactive interventions to halt large-scale humanitarian disasters.