Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-6bf8c574d5-t27h7 Total loading time: 0 Render date: 2025-02-23T16:35:17.681Z Has data issue: false hasContentIssue false

Chapter 5 - Maternal Vascular / Trophoblastic Developmental Abnormalities

from Section 3 - Maternal Uteroplacental-Vascular Pathology

Published online by Cambridge University Press:  03 September 2018

By
Raymond W. Redline
Edited by
Raymond W. Redline ,
Theonia K. Boyd  and
Drucilla J. Roberts
Raymond W. Redline
Affiliation:
Case Western Reserve University, Ohio
Theonia K. Boyd
Affiliation:
Harvard Medical School, Boston
Drucilla J. Roberts
Affiliation:
Harvard Medical School, Boston
Get access
Type
Chapter
Information
Placental and Gestational Pathology , pp. 49 - 57
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brosens, I, Pijnenborg, R, Vercruysse, L, et al. The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol. 2010;204:193–201.Google Scholar
Khong, TY, De Wolf, F, Robertson, WB, et al. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol. 1986;93:1049–59.CrossRefGoogle ScholarPubMed
Sebire, NJ, Fox, H, Backos, M, et al. Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod. 2002;17:1067–71.Google Scholar
Morgan, T, Craven, C, Lalouel, JM, et al. Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spiral arteries in first-trimester decidua. Am J Obstet Gynecol. 1999;180:95–102.Google Scholar
Caniggia, I, Winter, J, Lye, SJ, et al. Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia. Placenta. 2000;21 Suppl A:S25–30.CrossRefGoogle ScholarPubMed
Bose, P, Kadyrov, M, Goldin, R, et al. Aberrations of early trophoblast differentiation predispose to pregnancy failure: lessons from the anti-phospholipid syndrome. Placenta. 2006;27:869–75.Google Scholar
van Dijk, M, Visser, A, Posthuma, J, et al. Naturally occurring variation in trophoblast invasion as a source of novel (epigenetic) biomarkers. Front Genet. 2012;3(22):1–6.CrossRefGoogle ScholarPubMed
Redline, RW, Boyd, T, Campbell, V, et al. Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol. 2004;7:237–49.Google Scholar
DaSilva-Arnold, S, James, JL, Al-Khan, A, et al. Differentiation of first trimester cytotrophoblast to extravillous trophoblast involves an epithelial-mesenchymal transition. Placenta. 2015;36:1412–8.Google Scholar
Stanek, J, Biesiada, J. Sensitivity and specificity of finding of multinucleate trophoblastic giant cells in decidua in placentas from high-risk pregnancies. Hum Pathol. 2012;43:261–8.Google Scholar
Caniggia, I, Mostachfi, H, Winter, J, et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest. 2000;105:577–87.CrossRefGoogle ScholarPubMed
van Dijk, M, van Bezu, J, van Abel, D, et al. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol Genet. 2010;19:2658–67.Google Scholar
Wright, JK, Dunk, CE, Amsalem, H, et al. HER1 signaling mediates extravillous trophoblast differentiation in humans. Biol Reprod. 2010;83:1036–45.Google Scholar
Nadeem, L, Munir, S, Fu, G, et al. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol. 2011;178:1177–89.Google Scholar
Founds, SA, Fallert-Junecko, B, Reinhart, TA, et al. LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion. Placenta. 2013;34:248–55.Google Scholar
Smith, GN, Walker, MC, Liu, A, et al. A history of preeclampsia identifies women who have underlying cardiovascular risk factors. Am J Obstet Gynecol. 2009;200:58 e1–8.CrossRefGoogle ScholarPubMed
Spinillo, A, Gardella, B, Bariselli, S, et al. Placental histopathological correlates of umbilical artery Doppler velocimetry in pregnancies complicated by fetal growth restriction. Prenat Diagn. 2012;32:1263–72.CrossRefGoogle ScholarPubMed
Naeye, RL. Pregnancy hypertension, placental evidences of low utero-placental blood flow and spontaneous premature delivery. Hum Pathol. 1989;20:441–4.Google Scholar
Gibbins, KJ, Silver, RM, Pinar, H, et al. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta. 2016;43:61–8.Google Scholar
Barker, DJ, Bull, AR, Osmond, C, et al. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990;301:259–62.Google Scholar
Burke, C, Gobe, G. Pontosubicular apoptosis (“necrosis”) in human neonates with intrauterine growth retardation and placental infarction. Virchows Arch. 2005;446:640–5.Google Scholar
Roberts, JM, Gammill, HS. Preeclampsia: recent insights. Hypertension. 2005;46:1243–9.Google Scholar
Lee, Y, Kim, KR, McKeon, F, et al. A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Hum Pathol. 2007;38:1003–13.Google Scholar
Shih, IM, Kurman, RJ. p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Am J Surg Pathol. 2004;28:1177–83.CrossRefGoogle ScholarPubMed
Damsky, CH, Fitzgerald, ML, Fisher, SJ. Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest. 1992;89:210–22.Google Scholar
Zhou, Y, Damsky, CH, Chiu, K, et al. Preeclampsia Is Associated with Abnormal Expression of Adhesion Molecules by Invasive Cytotrophoblasts. J Clinical Invest. 1993;91:950–60.Google Scholar
Redline, RW, Patterson, P. Preeclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol. 1995;26:594–600.Google Scholar
Wasmoen, TL, Coulam, CB, Benirschke, K, et al. Association of immunoreactive eosinophil major basic protein with placental septa and cysts. Am J Obstet Gynecol. 1991;165:416–20.CrossRefGoogle ScholarPubMed
Stanek, J. Placental membrane and placental disc microscopic chorionic cysts share similar clinicopathologic associations. Pediatr Dev Pathol. 2011;14:1–9.Google Scholar
Stanek, J. Placental membrane laminar necrosis and chorionic microcysts. Pediatr Dev Pathol. 2012;15:514–6.Google Scholar
Shih, IM, Kurman, RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol. 2001;20:31–47.Google Scholar
Han, SH, Kim, KR, Kim, SA, et al. Histological and immunohistochemical findings of the intermdiate trophoblasts in normal and pre-eclamptic placentas. Mod Pathol. 2010;23(2):246A.Google Scholar
Kovo, M, Schreiber, L, Ben-Haroush, A, et al. Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction. Am J Obstet Gynecol. 2010;202:561 e1–5.Google Scholar
Kitzmiller, JL, Watt, N, Driscoll, SG. Decidual arteriopathy in hypertension and diabetes in pregnancy: immunofluorescent studies. Am J Obstet Gynecol. 1981;141:773–9.Google Scholar
Abramowsky, CR, Vegas, ME, Swinehart, G, et al. Decidual vasculopathy of the placenta in lupus erythematosus. N Engl J Med. 1980;303:668–72.CrossRefGoogle ScholarPubMed
Sebire, NJ, Backos, M, El Gaddal, S, et al. Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent miscarriage patients. Obstet Gynecol. 2003;101:258–63.Google Scholar
Stevens, DU, Al-Nasiry, S, Bulten, J, et al. Decidual vasculopathy in preeclampsia: lesion characteristics relate to disease severity and perinatal outcome. Placenta. 2013;34:805–9.Google Scholar
De Wolf, F, Robertson, WB, Brosens, I. The ultrastructure of acute atherosis in hypertensive pregnancy. Am J Obstet Gynecol. 1975;123:164–74.Google Scholar
Maynard, SE, Min, JY, Merchan, J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649–58.Google Scholar
Levine, RJ, Lam, C, Qian, C, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992–1005.Google Scholar
Burke, SD, Zsengeller, ZK, Khankin, EV, et al. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016;126:2561–74.Google Scholar
Lefkou, E, Mamopoulos, A, Dagklis, T, et al. Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy. J Clin Invest. 2016;126:2933–40.Google Scholar
Walford, N, Htun, K, Akhilesh, M. Detection of atherosis in preeclamptic placentas: comparison of two gross sampling protocols. Pediatr Dev Pathol. 2005;8:61–5.Google Scholar
Chan, JS, Heller, D, Baergen, R. Decidual vasculopathy: placental location and association with ischemic lesions. Pediatr Dev Pathol. 2017;20:44–48.Google Scholar
Veerbeek, JH, Post Uiterweer, ED, Nikkels, PG, et al. Biopsy techniques to study the human placental bed. Placenta. 2015;36:775–82.Google Scholar
Hecht, JL, Zsengeller, ZK, Spiel, M, et al. Revisiting decidual vasculopathy. Placenta. 2016;42:37–43.Google Scholar
Khong, TY, Mooney, EE, Ariel, I, et al. Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016;140:698–713.Google Scholar
Stevens, DU, Al-Nasiry, S, Fajta, MM, et al. Cardiovascular and thrombogenic risk of decidual vasculopathy in preeclampsia. Am J Obstet Gynecol. 2014;210:545 e1–6.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×