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from Section I - Basic Principles
Published online by Cambridge University Press: 26 February 2021
Pharmacokinetics is the study of the way in which the body handles administered drugs. The use of mathematical models allows us to predict how plasma concentration changes with time when the dose and interval between doses are changed, or when infusions of a drug are used. Because there is an association between plasma concentration of a drug and its pharmacodynamic effect, models allow us to predict the extent and duration of clinical effects. Mathematical models may therefore be used to programme computers to deliver a variable rate infusion to achieve a predetermined plasma level and hence a desired therapeutic effect.
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