Book contents
- Pharmacology for Anaesthesia and Intensive Care
- Pharmacology for Anaesthesia and Intensive Care
- Copyright page
- Contents
- Preface
- Foreword
- Section I Basic Principles
- Chapter 1 Drug Passage across the Cell Membrane
- Chapter 2 Absorption, Distribution, Metabolism and Excretion
- Chapter 3 Drug Action
- Chapter 4 Drug Interaction
- Chapter 5 Isomerism
- Chapter 6 Pharmacokinetic Modelling
- Chapter 7 Applied Pharmacokinetic Models
- Chapter 8 Medicinal Chemistry
- Section II Core Drugs in Anaesthetic Practice
- Section III Cardiovascular Drugs
- Section IV Other Important Drugs
- Index
Chapter 1 - Drug Passage across the Cell Membrane
from Section I - Basic Principles
Published online by Cambridge University Press: 26 February 2021
- Pharmacology for Anaesthesia and Intensive Care
- Pharmacology for Anaesthesia and Intensive Care
- Copyright page
- Contents
- Preface
- Foreword
- Section I Basic Principles
- Chapter 1 Drug Passage across the Cell Membrane
- Chapter 2 Absorption, Distribution, Metabolism and Excretion
- Chapter 3 Drug Action
- Chapter 4 Drug Interaction
- Chapter 5 Isomerism
- Chapter 6 Pharmacokinetic Modelling
- Chapter 7 Applied Pharmacokinetic Models
- Chapter 8 Medicinal Chemistry
- Section II Core Drugs in Anaesthetic Practice
- Section III Cardiovascular Drugs
- Section IV Other Important Drugs
- Index
Summary
Many drugs need to pass through one or more cell membranes to reach their site of action. A common feature of all cell membranes is a phospholipid bilayer, about 10 nm thick, arranged with the hydrophilic heads on the outside and the lipophilic chains facing inwards. This gives a sandwich effect, with two hydrophilic layers surrounding the central hydrophobic one. Spanning this bilayer or attached to the outer or inner leaflets are glycoproteins, which may act as ion channels, receptors, intermediate messengers (G-proteins) or enzymes. The cell membrane has been described as a ‘fluid mosaic’ as the positions of individual phosphoglycerides and glycoproteins are by no means fixed (Figure 1.1).
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- Pharmacology for Anaesthesia and Intensive Care , pp. 1 - 7Publisher: Cambridge University PressPrint publication year: 2021