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Chapter 17 - Antihypertensives

from Section III - Cardiovascular Drugs

Published online by Cambridge University Press:  26 February 2021

Tom Peck  and
Benjamin Harris
Tom Peck
Affiliation:
Royal Hampshire County Hospital, Winchester and University Hospital Southampton
Benjamin Harris
Affiliation:
Hampshire Hospitals NHS Trust
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Summary

Renin (half-life 80 minutes) splits the decapeptide angiotensin I from the circulating plasma protein angiotensinogen, which is synthesised in the liver and is present in the α2-globulin fraction of plasma proteins. Angiotensin-converting enzyme (ACE) converts angiotensin I to the active octapeptide angiotensin II, and also inactivates bradykinin. Angiotensin II is broken down in the kidney and liver to inactive metabolites and angiotensin III, which retains some activity (Figure 17.1).

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Pharmacology for Anaesthesia and Intensive Care , pp. 245 - 252
Publisher: Cambridge University Press
Print publication year: 2021

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