Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-19T15:18:06.349Z Has data issue: false hasContentIssue false

1 - Biomechanics of pediatric TBI

Published online by Cambridge University Press:  14 May 2010

Vicki Anderson
Affiliation:
University of Melbourne
Keith Owen Yeates
Affiliation:
Ohio State University
Get access

Summary

Traumatic brain injury (TBI) is a leading cause of death and disability among children and young adults in the United States (NCIPC, 2000). Each year TBI results in approximately 3000 childhood deaths, 29,000 hospitalizations, and 400,000 emergency department visits. The predominant causes of TBI in young children are motor vehicle accidents, firearm incidents, falls, and child abuse.

Since the 1940s biomechanics has made a significant contribution to understanding the mechanisms and tolerances of adult traumatic brain injury and it continues to play a crucial role in forming guidelines for adult motor vehicle occupancy and sports safety (Goldsmith, 2001; Goldsmith & Monson, 2005). Biomechanical research specific to pediatric traumatic brain injury did not begin until the late 1970s and the paucity of pediatric biomechanical data at the time forced researchers to make assumptions regarding the relationship of infant material properties to adult material properties (Mohan et al., 1979). Since then, biomechanical researchers have measured many pediatric tissue properties directly. Biomechanical studies of the intact skull and brain and the properties of individual tissues have demonstrated that the pediatric brain and skull respond differently to loads than adult tissue, and previous linear extrapolation from adult data does not provide an accurate estimate of pediatric properties (Coats & Margulies, 2006; Prange & Margulies, 2002).

Despite the increased research in the field, not enough key pieces of information are in place to establish realistic injury tolerances for children.

Type
Chapter
Information
Pediatric Traumatic Brain Injury
New Frontiers in Clinical and Translational Research
, pp. 7 - 17
Publisher: Cambridge University Press
Print publication year: 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adelson, P. D., Robichaud, P., Hamilton, R. L. & Kochanek, P. M. (1996). A model of diffuse traumatic brain injury in the immature rat. Journal of Neurosurgery, 85, 877–884.CrossRefGoogle ScholarPubMed
Alexander, R., Sato, Y., Smith, W. & Bennett, T. (1990). Incidence of impact trauma with cranial injuries ascribed to shaking. American Journal of Diseases of Children, 144, 724–726.Google ScholarPubMed
Arbogast, K. & Margulies, S. (1999). A fiber-reinforced composite model of the viscoelastic behaviour of the brainstem in shear. Journal of Biomechanics, 32, 865–870.CrossRefGoogle ScholarPubMed
Armstead, W. & Kurth, C. (1994). Different cerebral hemodynamic responses following fluid percussion brain injury in the newborn and juvenile pig. Journal of Neurotrauma, 11, 487–497.CrossRefGoogle ScholarPubMed
Atwal, G. S., Rutty, G. N., Carter, N. & Green, M. A. (1998). Bruising in non-accidental injured children; a retrospective study of the prevalence, distribution and pathological associations in 24 cases. Forensic Science International, 96, 215–230.CrossRefGoogle ScholarPubMed
Bertocci, G. E., Pierce, M. C., Deemer, E., Aguel, F., Janosky, J. E. & Vogeley, E. (2003). Using test dummy experiments to investigate pediatric injury risk in simulated short-distance falls. Archives of Pediatrics and Adolescent Medicine, 157, 480–486.CrossRefGoogle ScholarPubMed
Bittigau, P., Sifringer, M., Pohl, D.et al. (1999). Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain. Annals of Neurology, 45, 724–735.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
Breton, F., Pincemaile, Y., Tarriere, C. & Renault, B. (1991). Event-related potential assessment of attention and the orienting reaction in boxers before and after a fight. Biological Psychology, 31, 57–71.CrossRefGoogle ScholarPubMed
Buckley, N. (1986). Maturation of circulatory system in three mammalian models of human development. Comparative Biochemistry and Physiology, 83A, 1–7.Google Scholar
,CDC (2005). Wisqar Database. NCIPC – WISQAR Database.
Cloots, R. J. H., Gervaise, H. M. T., Dommelen, J. A. W. & Geers, M. G. D. (2008). Biomechanics of traumatic brain injury: influences of the morphologic heterogeneities of the cerebral cortex. Annals of Biomedical Engineering, 36, 1203–1215.CrossRefGoogle ScholarPubMed
Coats, B. (2007). Mechanics of head impact in infants. Ph.D. thesis, Department of Bioengineering, University of Pennsylvania, Philadelphia.Google Scholar
Coats, B., Ji, S. & Margulies, S. S. (2007). Parametric study of head impact in the infant. Stapp Car Crash Journal, 51, 1–15.Google ScholarPubMed
Coats, B. & Margulies, S. S. (2006). Material properties of human infant skull and suture at high rates. Journal of Neurotrauma, 23, 1222–1232.CrossRefGoogle ScholarPubMed
Coats, B. & Margulies, S. S. (2008). Potential for head injuries in infants from low-height falls. Journal of Neurosurgery: Pediatrics, 2, 1–10.Google ScholarPubMed
Deck, C. & Willinger, R. (2008). Improved head injury criteria based on head fe model. International Journal of Crashworthiness, 13, 667–678.CrossRefGoogle Scholar
Dickerson, J. & Dobbing, J. (1966). Prenatal and postnatal growth and development of the central nervous system of the pig. Proceedings of the Royal Society of London, Series B, 166, 384–395.CrossRefGoogle Scholar
Dobbing, J. (1974). The later growth of the brain and its vulnerability. Pediatrics, 53, 2–6.Google ScholarPubMed
Dobbing, J. & Sands, J. (1973). Quantitative growth and development of human brain. Archives of Disease in Childhood, 48, 757–767.CrossRefGoogle ScholarPubMed
Duhaime, A., Gennarelli, T., Thibault, L., Bruce, D., Margulies, S. & Wiser, R. (1987). The shaken baby syndrome: a clinical, pathological, and biomechanical study. Journal of Neurosurgery, 66, 409–415.CrossRefGoogle ScholarPubMed
Duhaime, A. C., Margulies, S. S., Durham, S. R.et al. (2000). Maturation-dependent response of the piglet brain to scaled cortical impact. Journal of Neurosurgery, 93, 455–462.CrossRefGoogle ScholarPubMed
Duhaime, A. C., Hunter, J. V., Grate, L. L.et al. (2003). Magnetic resonance imaging studies of age-dependent responses to scaled focal brain injury in the piglet. Journal of Neurosurgery, 99, 542–548.CrossRefGoogle ScholarPubMed
Eucker, S., Friess, S., Ralston, J. & Margulies, S. (2008). Regional Cerebral Blood Flow Response Following Brain Injury Depends on Direction of Head Motion. Orlando, FL:National Neurotrauma Society.Google Scholar
Galbraith, J. (1988). The Effects of Mechanical Loading on the Electrophysiology of the Squid Giant Axon. Philadelphia: University of Pennsylvania.Google Scholar
Galbraith, J. A., Thibault, L. E. & Matteson, D. R. (1993). Mechanical and electrical responses of the squid giant axon to simple elongation. Journal of Biomechanical Engineering, 115, 13–22.CrossRefGoogle ScholarPubMed
Gefen, A., Gefen, N., Zhu, Q., Raghupathi, R. & Margulies, S. (2003). Age-dependent changes in material properties of the brain and braincase of the rat. Journal of Neurotrauma, 20, 1163–1177.CrossRefGoogle ScholarPubMed
Gennarelli, T. (1996). The spectrum of traumatic axonal injury. Neuropathology & Applied Neurobiology, 22, 509–513.CrossRefGoogle ScholarPubMed
Gennarelli, T. A. & Thibault, L. E. (1982). Biomechanics of acute subdural hematoma. Journal of Trauma, 22, 680–686.CrossRefGoogle ScholarPubMed
Gennarelli, T. A., Ommaya, A. K. & Thibault, L. E. (1971). Comparison of linear and rotational accelerations in experimental cerebral concussion. Proceedings of the 15th Stapp Car Crash Conference, New York, Society of Automotive Engineers, pp. 797–803.Google Scholar
Gennarelli, T., Thibault, L. & Ommaya, A. (1972). Pathophysiologic responses to rotational and translational acceleration of the head. Proceedings of the 16th Stapp Car Crash Conference, New York, Society of Automotive Engineers, pp. 296–308.Google Scholar
Gennarelli, T., Abel, J., Adams, H. & Graham, D. (1979). Differential tolerance of frontal and temporal lobes to contusion induced by angular acceleration. Proceedings of the 23rd Stapp Car Crash Conference, New York, Society of Automotive Engineers.Google Scholar
Gennarelli, T., Thibault, L., Adams, J., Graham, D., Thompson, C. & Marcincin, R. (1982). Diffuse axonal injury and traumatic coma in the primate. Annals of Neurology, 12, 564–574.CrossRefGoogle ScholarPubMed
Gennarelli, T. A., Thibault, L. E., Tomei, G., Wiser, R., Graham, D. I. & Adams, J. H. (1987). Directional dependence of axonal brain injury due to centroidal and non-centroidal acceleration. Proceedings of the 31st Stapp Car Crash Conference, Warrendale, PA, Society of Automotive Engineers, pp. 49–53.Google Scholar
Goldsmith, W. (2001). The state of head injury biomechanics: past, present, and future: Part 1. Critical Reviews in Biomedical Engineering, 29, 441–600.CrossRefGoogle ScholarPubMed
Goldsmith, W. & Monson, K. (2005). The state of head injury biomechanics: past, present, and future: Part 2. Critical Reviews in Biomedical Engineering, 33, 105–207.CrossRefGoogle ScholarPubMed
Grundl, P., Biagas, K., Kochanek, P., Schiding, J., Barmada, M. & Nemoto, E. (1994). Early cerebrovascular response to head injury in immature and mature rats. Journal of Neurotrauma, 11, 135–148.CrossRefGoogle ScholarPubMed
Hubbard, R. (1971). Flexure of layered cranial bone. Journal of Biomechanics, 4, 251–263.CrossRefGoogle ScholarPubMed
Kapoor, T., Altenhof, W. & Howard, A. (2005). The effect of using universal anchorages in child restraint seats on the injury potential for children in frontal crash. International Journal of Crashworthiness, 10, 305–314.CrossRefGoogle Scholar
Klinich, K., Hulbert, G. & Schneider, L. (2002). Estimating infant head injury criteria and impact response using crash reconstruction and finite element modeling. Stapp Car Crash Journal, 46, 165–194.Google Scholar
Kraus, J., Fife, D. & Conroy, C. (1987). Pediatric brain injuries: the nature, clinical course, and early outcomes in a defined united stated population. Pediatrics, 79, 501–507.Google Scholar
Kraus, J., Rock, A. & Hemyari, P. (1990). Brain injuries among infants, children, adolescents, and young adults. American Journal of Diseases of Children, 144, 684–691.Google Scholar
Lapeer, R. J. & Prager, R. W. (2001). Fetal head moulding: finite element analysis of a fetal skull subjected to uterine pressures during the first stage of labour. Journal of Biomechanics, 34, 1125–1133.CrossRefGoogle ScholarPubMed
Margulies, S., Thibault, L. & Gennarelli, T. (1990). Physical model simulations of brain injury in the primate. Journal of Biomechanics, 23, 823–836.CrossRefGoogle ScholarPubMed
McPherson, G. & Kriewall, T. (1980a). The elastic modulus of fetal cranial bone: a first step toward understanding of the biomechanics of fetal head molding. Journal of Biomechanics, 13, 9–16.CrossRefGoogle Scholar
McPherson, G. K. & Kriewall, T. J. (1980b). Fetal head molding: an investigation utilizing a finite element model of the fetal parietal bone. Journal of Biomechanics, 13, 17–26.CrossRefGoogle ScholarPubMed
Meaney, D. F. (1991). Biomechanics of acute subdural hematoma in the subhuman primate and man. Ph.D. thesis, Department of Bioengineering. University of Pennsylvania, Philadelphia.
Miller, R., Margulies, S., Leoni, M.et al. (1998). Finite element modeling approaches for predicting injury in an experimental model of severe diffuse axonal injury. Proceedings of the 42nd Stapp Car Crash Conference, Warrendale, PA, Society of Automotive Engineers, pp. 155–167.Google Scholar
Mohan, D., Bowman, B., Snyder, R. & Foust, D. (1979). A biomechanical analysis of head impact injuries to children. Journal of Biomechanical Engineering, 101, 250–260.CrossRefGoogle Scholar
,NCIPC (2000). Traumatic Brain Injury in the United States: Assessing Outcomes in Children. Atlanta, Georgia Centers for Disease Control and Prevention: National Center for Injury Prevention and Control.
Pampiglione, G. (1971). Some aspects of development of cerebral function in mammals. Proceeding of the Royal Society of Medicine, 64, 429–435.Google ScholarPubMed
Pellmen, E. J., Viano, D. C., Tucker, A. M., Casson, I. R. & Waeckerle, J. F. (2003). Concussion in professional football: reconstruction of game impacts and injuries. Neurosurgery, 53, 799–814.CrossRefGoogle Scholar
Prange, M. (2002). Biomechanics of traumatic brain injury in the infant. Ph.D. thesis, Department of Bioengineering. University of Pennsylvania, Philadelphia.
Prange, M. & Margulies, S. (2002). Regional, directional, and age-dependent properties of brain undergoing large deformation. Journal of Biomechanical Engineering, 124, 244–252.CrossRefGoogle ScholarPubMed
Prange, M., Meaney, D. & Margulies, S. (2000). Defining brain mechanical properties: effects of region, direction, and species. Proceedings of the 44th Stapp Car Crash Conference, Warrendale, PA, Society of Automotive Engineers, pp. 205–213.Google Scholar
Prange, M., Coats, B., Duhaime, A. C. & Margulies, S. (2003). Anthropomorphic simulations of falls, shakes, and inflicted impacts in infants. Journal of Neurosurgery, 99, 143–150.CrossRefGoogle ScholarPubMed
Prins, M., Lee, S., Cheng, C., Becker, D. & Hovda, D. (1996). Fluid percussion brain injury in the developing and adult rat: a comparative study of mortality, morphology, intracranial pressure and mean arterial blood pressure. Developmental Brain Research, 95, 272–282.CrossRefGoogle ScholarPubMed
Raghupathi, R. & Margulies, S. S. (2002). Traumatic axonal injury after closed head injury in the neonatal pig. Journal of Neurotrauma, 19, 843–853.CrossRefGoogle ScholarPubMed
Raghupathi, R., Mehr, M., Helfaer, M. & Margulies, S. (2004). Traumatic axonal injury is exacerbated following repetitive close head injury in the neonatal pig. Journal of Neurotrauma, 21, 307–316.CrossRefGoogle ScholarPubMed
Raul, J. S., Roth, S., Ludes, B. & Willinger, R. (2008). Influence of the benign enlargement of the subarachnoid space on the bridging veins strain during a shaking event: a finite element study. International Journal of Legal Medicine, 122, 337–340.CrossRefGoogle ScholarPubMed
Roth, S., Raul, J. S., Ludes, B. & Willinger, R. (2006). Finite element analysis of impact and shaking inflicted to a child. International Journal of Legal Medicine, 121, 223–228.CrossRefGoogle Scholar
Smith, D. H., Nonaka, M., Miller, R.et al. (2000). Immediate coma following inertial brain injury dependent on axonal damage in the brainstem. Journal of Neurosurgery, 93, 315–322.CrossRefGoogle ScholarPubMed
Strouse, P. J., Caplan, M. & Owings, C. L. (1998). Extracranial soft-tissue swelling: a normal postmortem radiographic finding or a sign of trauma?Pediatric Radiology, 28, 594–596.CrossRefGoogle ScholarPubMed
Wagerle, L., Kumar, S. & Delivoria-Papadopoulos, M. (1986). Effect of sympathetic nerve stimulation on cerebral blood flow in newborn piglets. Pediatric Research, 20, 131–135.CrossRefGoogle ScholarPubMed
Wittek, A. & Omori, K. (2003). Parametric study of effects of brain–skull boundary conditions and brain material properties on responses of simplified finite element brain model under angular acceleration impulse in sagittal plane. JSME International Journal Series C – Mechanical Systems Machine Elements and Manufacturing, 46, 1388–1399.CrossRefGoogle Scholar
Yamada, H. (1970). Strength of Biological Materials. Baltimore: Williams and Wilkins Co.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×