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Chapter 24 - Histiocytic Pathogenesis and Derivation

from Section VI - Histiocytic Disorders and Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Jennifer Picarsic
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

The term histiocyte (tissue cell) has evolved and is now often used as a collective term for two related groups of immune regulatory cells, the monocyte-macrophages and the dendritic cell (DC)–accessory antigen-presenting cells (1). The histiocytic proliferations of childhood encompass benign and malignant accumulations of monocyte-macrophages and hematopoietic-derived DC with a clinical spectrum of indolent to aggressive lesions. Although distinguishing between their reactive and neoplastic states can be challenging at times, molecular-based testing can help refine the diagnosis of neoplastic accumulations (see also Chapter 28) (2, 3).

Type
Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 307 - 309
Publisher: Cambridge University Press
Print publication year: 2024

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