This chapter is focused on understanding the experience of children and young people. It explores how the meaning of the illness shapes the experiences. The findings on the impact of parental cancer, according to research, has mixed findings. Cancer research methodologies are varied and therefore comparisons between studies is difficult. Children and young people can experience positive outcomes from parental cancer, such as maturity and personal growth, not only negative ones which have also been reported by the literature such as depression and anxiety. Different factors including illness stage, age, sex, coping skills, previous knowledge and relationships with professionals can impact parental cancer.