Sleepwalking is not the only NREM parasomnia that has been observed to be associated with medication or substance. It is, however, the most common group, the one most familiar to psychiatrists, who noted this as a side effect following initiation or escalation of some medications used for treating their patients, particularly those with bipolar depression in manic episodes, schizoaffective patients and anxiety patients with insomnia. This chapter covers the published reports in which sleepwalking event occurred closely following the initiation of medication and its resolution on withdrawal from the drug. The anti-depressant medications and their effects on sleep, few studies give the effects on slow-wave sleep (SWS). The benzodiazepine that has been most clearly associated with sleep-related eating disorder (SRED) is triazolam, although it is associated with initiation of several other NREM parasomnias.