Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-22T11:12:02.394Z Has data issue: false hasContentIssue false

9 - Tumours

Published online by Cambridge University Press:  05 June 2012

Tony Waldron
Affiliation:
University College London
Get access

Summary

Although the word tumour simply means a swelling, in the minds of most people it has unpleasant connotations as it is frequently taken as a synonym for cancer, which it is not. Without any further elaboration, a tumour is simply a new growth and on this account it is sometimes also known as a neoplasm, and the process by which it arises, as neoplasia. Tumours may be classified as either primary or secondary, or as either benign or malignant. A primary tumour is one that originates in the tissue in which it is found, whereas a secondary tumour is one that has arisen in a different tissue from that in which it is found. A benign tumour does not spread beyond the tissue in which it originates. By contrast, the characteristic of a malignant tumour is that it does spread beyond its tissue of origin. Malignant tumours are often a cause of death whereas this is generally not the case with benign tumours, although there are exceptions as we shall see. A secondary tumour is malignant by definition, but a primary tumour may be either benign or malignant.

EPIDEMIOLOGY OF BONE TUMOURS

Primary bone tumours are uncommon and benign tumours are much more common than malignant. Malignant primary tumours of bone account for less than 1% of all malignant tumours and are more common in males than in females except in late childhood when there is a very slight female excess. The male excess becomes increasingly apparent with increasing age.

Type
Chapter
Information
Palaeopathology , pp. 168 - 190
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Doll, R and Peto, R, The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today, Journal of the National Cancer Institute, 1981, 66, 1191–1308.CrossRefGoogle ScholarPubMed
Bones, bodies and disease, London, Thames and Hudson, 1964, p 73
Micozzi, MS, Disease in antiquity. The case of cancer, Archives of Pathology and Laboratory Medicine, 1991, 115, 838–844.Google Scholar
Waldron, T, What was the prevalence of malignant disease in the past?International Journal of Osteoarchaeology, 1996, 6, 463–470.3.0.CO;2-Y>CrossRefGoogle Scholar
Nerlich, AG, Rohrback, H, Backmeier, B and Zink, A, Malignant tumors in two ancient populations: an approach to historical tumor epidemiology, Oncology Reports, 2006, 16, 197–202.Google ScholarPubMed
Resnick, D and Niwayama, G, Diagnosis of bone and joint disorders, 2nd edition, Philadelphia, WB Saunders, 1988, p 3617Google Scholar
Patel, TR and Borah, GL, Frontal bone periosteal osteomas, Plastic and Reconstructive Surgery, 2004, 114, 648–651.CrossRefGoogle ScholarPubMed
Eller, R and Sillers, M, Common fibro-osseous lesions of the paranasal sinuses, Otolaryngologic Clinics of North America, 2006, 39, 585–600.CrossRefGoogle ScholarPubMed
Harrison, DF, The relationship of osteomata of the external auditory meatus to swimming, Annals of the Royal College of Surgeons of London, 1962, 31, 187–201.Google ScholarPubMed
Greenspan, A, Bone island (enostosis): current concept – a review, Skeletal Radiology, 1995, 24, 111–115.CrossRefGoogle ScholarPubMed
Kitsoulis, P, Mantellos, G and Vlychou, M, Osteoid osteoma, Acta Othopaedica Belgica, 2006, 72, 119–125.Google ScholarPubMed
Lucas, DR, Unni, KK, McLeod, RA, MI O'Connor and FH Sim, Osteoblastoma: a clinicopathologic study of 306 cases, Human Pathology, 1994, 25, 117–134.CrossRefGoogle Scholar
Caulke, R, The distribution of solitary enchondromata at the hand, Journal of Hand Surgery, 2002, 27, 444–445.Google Scholar
Miyawaki, T, Kinoshita, Y and Tizuka, T, A case of Ollier's disease of the hand, Annals of Plastic Surgery, 1997, 38, 77–80.CrossRefGoogle ScholarPubMed
Kaplan, RP, Wang, JT, Amron, DM and Kaplan, L, Maffucci's syndrome: two case reports with a literature review, Journal of the American Academy of Dermatology, 1993, 29, 894–899.CrossRefGoogle ScholarPubMed
Mellon, CD, Carter, JE and Owen, DB, Ollier's disease and Maffucci's syndrome: distinct entities or a continuum?Journal of Neurology, 1988, 235, 376–378.CrossRefGoogle ScholarPubMed
Lewis, MM, Kenan, S, Yabut, SM, Norman, A and Steiner, G, Periosteal chondroma. A report of ten cases and review of the literature, Clinical Orthopaedics and Related Research, 1990, 256, 185–192.Google Scholar
Springfield, DS, Capanna, R, Gherlinzoni, F, Picci, P and Campanacci, M, Chondroblastoma. A review of seventy cases, Journal of Bone and Joint Surgery, 1985, 67A, 748–755CrossRefGoogle Scholar
Turcotte, RE, Kurt, AM, Sim, FH, Unnit, KK and McLeod, RA, Chondroblastoma, Human Pathology, 1993, 24, 944–949.CrossRefGoogle ScholarPubMed
Masui, F, Ushigome, S, Kamitani, K, Asanuma, K and Fujii, K, Chondroblastoma: a study of 11 cases, European Journal of Surgical Oncology, 2002, 28, 869–874.CrossRefGoogle ScholarPubMed
Ramappa, AJ, Lee, FY, Tang, P, Carlson, JR, Gebhardt, MC and Mankin, HJ, Chondroblastoma of bone, Journal of Bone and Joint Surgery, 2000, 82A, 1140–1145.CrossRefGoogle Scholar
Fuselier, CO, Binning, T, Kuschner, D, Kirchwehm, WW, Rice, JR, Hetherington, V, Kahl, RL, Hanley, DC, West, A and Gray, J, Solitary osteochondroma of the foot: an in-depth study with case reports, Journal of Foot Surgery, 1984, 23, 3–24.Google Scholar
Revilla, Y, Lozano, MC, Gonzalex, G and Martinez, A, Evanescent exostoses. A new case, European Journal of Radiology, 1999, 29, 270–272.CrossRefGoogle Scholar
Carpintero, P, Leon, F, Zafra, M, Montero, M and Berral, FJ, Fractures of osteochondroma during physical exercise, American Journal of Sports Medicine, 2003, 31, 1003–1006.CrossRefGoogle ScholarPubMed
Choi, JJ and Murphy, MD, Angiomatous skeletal lesions, Seminars in Musculoskeletal Radiology, 2000, 4, 103–112.CrossRefGoogle ScholarPubMed
Fox, MW and Onofrio, BM, The natural history and management of symptomatic and asymptomatic vertebral haemangiomas, Journal of Neurosurgery, 1993, 78, 36–45.CrossRefGoogle Scholar
Tremlin, CR, Stambough, JB and Stambough, JL, Acute spinal cord compression caused by vertebral hemangioma, Spine Journal, 2004, 4, 595–600.Google Scholar
Caffey, J, On fibrous defects in cortical walls of growing tubular bones, Advances in Pediatrics, 1955, 7, 13–15.Google Scholar
Resnick, D and Greenway, G, Distal femoral cortical defects, irregularities, and excavations, Radiology, 1982, 143, 345–354CrossRefGoogle ScholarPubMed
Smith, SE and Kransdorf, MJ, Primary musculoskeletal tumors of fibrous origin, Seminars in Musculoskeletal Radiology, 2000, 4, 73–88CrossRefGoogle ScholarPubMed
Blau, RA, Zwick, DL and Westphal, RA, Multiple non-ossifying fibromas. A case report, Journal of Bone and Joint Surgery, 1988, 70A, 299–304.CrossRefGoogle Scholar
Hoeffel, C, Panuel, M, Plenet, F, Mainard, L and Hoeffel, JC, Pathological fracture in non-ossifying fibromas with histological features simulating aneurysmal bone cyst, European Radiology, 1999, 9, 669–671.CrossRefGoogle ScholarPubMed
Baig, R and Eady, JL, Unicameral (simple) bone cysts, Southern Medical Journal, 2006, 99, 966–976.CrossRefGoogle ScholarPubMed
Leithner, A, Windhager, R, Lang, S, Haas, OA, Kaiberger, F and Kotz, R, Aneurysmal bone cyst. A population based epidemiologic study and literature review, Clinical Orthopaedics and Related Research, 1999, 363, 176–179.Google Scholar
Mankin, HJ, Hornicek, FJ, Ortiz-Cruz, E, Villafuerte, J and Gebhardt, MC, Aneurysmal bone cyst: a review of 150 patients, Journal of Clinical Oncology, 2005, 20, 6756–6762.CrossRefGoogle Scholar
Wenaden, AE, Szyszko, TA and Saifuddin, A, Imaging of periosteal reactions associated with focal lesions of bone, Clinical Radiology, 2005, 60, 439–456CrossRefGoogle Scholar
Yoshikawa, H, Nakase, T, Myoui, A and Ueda, T, Bone morphogenic proteins in bone tumours, Journal of Orthopedic Science, 2004, 9, 334–340CrossRefGoogle Scholar
Hayden, JB and Hoang, BH, Osteosarcoma: basic science and clinical implications, Orthopaedic Clinics of North America, 2006, 37, 1–7CrossRefGoogle ScholarPubMed
Kansara, M and Thomas, DM, Molecular pathogenesis of osteosarcoma, DNA and Cell Biology, 2007, 26, 1–18.CrossRefGoogle ScholarPubMed
Raymond, AK, Surface osteosarcoma, Clinical Orthopaedics and Related Research, 1991, 270, 140–148.Google Scholar
Okada, K, Unni, KK, Swee, RG and Sim, FH, High grade surface osteosarcoma. A clinicopathologic study of 46 cases, Cancer, 1999, 85, 1044–1054.3.0.CO;2-A>CrossRefGoogle ScholarPubMed
Mankin, HJ and Hornicek, FJ, Paget's sarcoma: a historical and outcome review, Clinical Orthopaedics and Related Research, 2005, 438, 97–102CrossRefGoogle ScholarPubMed
Haibach, H, Farrell, C and Dittrich, FJ, Neoplasms arising in Paget's disease of bone: a study of 82 cases, American Journal of Clinical Pathology, 1985, 83, 594–600CrossRefGoogle ScholarPubMed
Stiller, CA, Bielack, SS, Jundt, G and Steliarova-Foucher, E, Bone tumours in European children and adolescents, European Journal of Cancer, 2006, 42, 2124–2135.CrossRefGoogle ScholarPubMed
Paulussen, M, Frohlic, B and Jurgens, H, Ewing tumour: incidence, prognosis and treatment options, Paediatric Drugs, 2001, 3, 899–913.CrossRefGoogle ScholarPubMed
Wagner, LM, Neel, MD, Pappo, AS, Merchant, TE, Poquette, CA, Rao, BN and Rodriguez-Galindo, C, Fractures in pediatric Ewing sarcoma, Journal of Pediatric Hematology and Oncology, 2001, 23, 568–571.CrossRefGoogle ScholarPubMed
Bruns, J, Elbrach, M and Niggemeyer, O, Chondrosarcoma of bone: an oncological and functional follow-up study, Annals of Oncolocy, 2001, 12, 859–864.CrossRefGoogle ScholarPubMed
Terek, RM, Recent advances in the basic science of chondrosarcoma, Orthopaedic Clinics of North America, 2006, 37, 9–14.CrossRefGoogle ScholarPubMed
Huvos, AG and Higinbotham, NL, Primary fibrosarcoma of bone. A clinicopathologic study of 130 patients, Cancer, 1975, 35, 837–847.3.0.CO;2-U>CrossRefGoogle Scholar
Papagelopoulos, PJ, Galanis, E, Frassica, FJ, Sim, FH, Larson, DR and Wold, , Primary fibrosarcoma of bone. Outcome after primary surgical treatment, Clinical Orthopaedics and Related Research, 2000, 373, 88–103.CrossRefGoogle Scholar
Wenger, and Wold, , Malignant vascular lesions of bone: radiologic and pathologic features, Skeletal Radiology, 2000, 29, 619–631.CrossRefGoogle ScholarPubMed
Pattie, SB and Farrell, PJ, The role of Epstein-Barr virus in cancer, Expert Opinion on Biological Therapy, 2006, 6, 1193–1205CrossRefGoogle Scholar
Mwanda, OW, Rochford, R, Moormann, AM, Macnell, A, Whalen, C and Wilson, ML, Burkitt's lymphoma in Kenya: geographical, age, gender and ethnic distribution, East African Medical Journal, 2004, 8 (Supplement), S68–S77Google Scholar
Gebert, C, Hardes, J, Ahrens, H, Buerger, H, Winkelmann, W and Gosheger, G, Primary multifocal osseous Hodgkin's disease: a case report and review of the literature, Journal of Cancer Research and Clinical Oncology, 2005, 131, 163–168CrossRefGoogle ScholarPubMed
Kitsoulis, P, Vlychou, M, Papadou-Bai, A, Karatzias, G, Charchanti, A, Agnantis, NJ and Bai, M, Primary lymphomas of bone, Anticancer Research, 2006, 26, 325–337Google Scholar
Rosenthal, H, Kolb, R, Gratz, KF, Reiter, A and Galanski, M, Ossäre Manifestationen beim Non-Hodgkin-Lymphom im Kindes- und Jugendalter, Der Radiologe, 2000, 40, 737–744.CrossRefGoogle Scholar
Pear, BL, Skeletal manifestations of the lymphomas and leukemias, Seminars in Roentgenology, 1974, 9, 229–240.CrossRefGoogle ScholarPubMed
Davies, JH, Evans, BAJ, Jenney, MEM and Gregory, JW, Skeletal morbidity in children with acute lymphoblastic leukaemia, Clinical Endocrinology, 2005, 63, 1–9.CrossRefGoogle ScholarPubMed
Gallagher, DG, Phillips, DJ and Heinrich, SD, Orthopedic manifestations of acute pediatric leukemia, Orthopedic Clinics of North America, 1996, 27, 635–644Google ScholarPubMed
Manson, D, Martin, RF and Cockshott, WP, Metaphyseal impaction fractures in acute lymphoblastic leukemia, Skeletal Radiology, 1989, 17, 561–564.CrossRefGoogle ScholarPubMed
Schable, SI, Tyminski, L, Holland, RD and Rittenberg, GM, The skeletal manifestations of chronic myelogenous leukemia, Skeletal Radiology, 1980, 5, 145–149.CrossRefGoogle Scholar
Jacobson, HG, Poppel, MH, Shapiro, JH and Grossberger, S, The vertebral pedicle sign: a roentgen finding to differentiate metastatic carcinoma from multiple myeloma, American Journal of Roentgenology, 1958, 80, 817–821.Google ScholarPubMed
Sezer, O, Myeloma bone disease, Hematology, 2005, 10 Supplement 1, 19–24.CrossRefGoogle ScholarPubMed
Hjertner, O, Standal, T, Borset, M, Sundan, A and Waage, A, Bone disease in multiple myeloma, Medical Oncology, 2006, 23, 431–441.CrossRefGoogle ScholarPubMed
Giuliani, N, Rizzoli, and Roodman, GD, Multiple myeloma bone disease: pathophysiology of osteoblast inhibition, Blood, 2006, 108, 3992–3996.CrossRefGoogle ScholarPubMed
Keats, JJ, Reiman, T, Belch, AR and Pilarski, LM, Ten years and counting: so what do we know about t(4;14)(p16:q32) multiple myeloma, Leukemia and Lymphoma, 2006, 47, 2289–2300CrossRefGoogle Scholar
Bataille, R and Harousseau, J-L, Multiple myeloma, New England Journal of Medicine, 1997, 336, 1657–1664CrossRefGoogle ScholarPubMed
Sinclair, D, IgD myeloma: clinical, biological and laboratory features, Clinical Laboratory, 2002, 48, 617–622Google ScholarPubMed
Cattaneo, C, Gelsthorpe, K, Phillips, P, Waldron, T, Booth, JR and Sokol, RJ, Immunological diagnosis of multiple myeloma in a medieval bone, International Journal of Osteoarchaeology, 1994, 4, 1–2CrossRefGoogle Scholar
Resnick, D and Niwayama, G, Diagnosis of bone and joint disorders, 2nd edition, Philadelphia, WB Saunders, 1988, p 3617Google Scholar
Baud'huin, M, Duplomb, L, Velasco, C Ruiz, Fortun, Y, Heymann, D and Padrines, M, Key roles of the OPG-RANK-RANKL system in bone oncology, Expert Reviews of Anticancer Therapy, 2007, 7, 221–232CrossRefGoogle ScholarPubMed
Guise, TA, Kozlow, WM, Heras-Herzig, A, Padalecki, SS, Yin, JJ and Chirgwin, JM, Molecular mechanisms of breast cancer metastases to bone, Clinical Breast Cancer, 2005, 5 Supplement 2, S46–S53CrossRefGoogle ScholarPubMed
Keller, ET and Brown, J, Prostate cancer bone metastases promote both osteolytic and osteoblastic activity, Journal of Cellular Biochemistry, 2004, 91, 718–729CrossRefGoogle ScholarPubMed
Guise, TA and Chirgwin, JM, Transforming growth factor-beta in osteolytic breast cancer bone metastases, Clinical Orthopaedics and Related Research, 2003, 415 Supplement, S32–S38CrossRefGoogle Scholar
Zlotnik, A, Involvement of chemokine receptors in organ-specific metastases, Contributions to Microbioloogy, 2006, 13, 191–199CrossRefGoogle Scholar
Althuis, MD, Dozier, JM, Anderson, WF, Devesa, SS and Brinton, , Global trends in breast cancer incidence and mortality 1973–1997, International Journal of Epidemiology, 2005, 34, 405–412CrossRefGoogle ScholarPubMed
Shannon, C and Smith, IE, Breast cancer in adolescents and young women, European Journal of Cancer, 2003, 39, 2632–2642CrossRefGoogle ScholarPubMed
Strouhal, E, A case of metastatic carcinoma from Christian Sayala (Egyptian Nubia), Anthropologischer Anzeiger, 1993, 51, 97–115Google Scholar
Williams, MD and Sandler, AB, The epidemiology of lung cancer, Cancer Treatment and Research, 2001, 105, 31–52CrossRefGoogle ScholarPubMed
Subramanian, J and Govindan, R, Lung cancer in never smokers: a review, Journal of Clinical Oncology, 2007, 25, 561–570CrossRefGoogle ScholarPubMed
Hsing, AW and Chokkalingam, AP, Prostate cancer epidemiology, Frontiers in Bioscience, 2006, 11, 1388–1413CrossRefGoogle ScholarPubMed
Geldof, AA, Models for cancer skeletal metastasis: a reappraisal of Batson's plexus, Anticancer Research, 1997, 17, 1535–1539Google ScholarPubMed
Bloom, RA, Libson, E, Husband, JE and Stoker, DJ, The periosteal sunburst reaction to bone metastases. A literature review and report of 20 additional cases, Skeletal Radiology, 1987, 16, 629–634CrossRefGoogle ScholarPubMed
Grevin, G, Lagier, R and Baud, CA, Metastatic carcinoma of presumed prostatic origin in cremated bones from the first century AD, Virchows Archiv, 1997, 431, 211–214Google Scholar
Waldron, T, a nineteenth-century case of carcinoma of the prostate, with a note on the early history of the disease, International Journal of Osteoarchaeology, 1997, 7, 241–2473.0.CO;2-2>CrossRefGoogle Scholar
McLaughlin, JK, Lipworth, L and Tarone, RE, Epidemiological aspects of renal cell carcinoma, Seminars in Oncology, 2006, 33, 527–533CrossRefGoogle ScholarPubMed
Harach, HR and Williams, ED, Childhood thyroid cancer in England and Wales, British Journal of Cancer, 1995, 72, 777–783CrossRefGoogle ScholarPubMed
Reynolds, RM, Weir, J, Stockton, DL, Brewster, DH, Sandeep, TC and Strachan, RW, Changing trends in incidence and mortality of thyroid cancer in Scotland, Clinical Endocrinology, 2005, 62, 156–162CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Tumours
  • Tony Waldron, University College London
  • Book: Palaeopathology
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9780511812569.010
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Tumours
  • Tony Waldron, University College London
  • Book: Palaeopathology
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9780511812569.010
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Tumours
  • Tony Waldron, University College London
  • Book: Palaeopathology
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9780511812569.010
Available formats
×