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6 - Setup and analysis of PGSE experiments

Published online by Cambridge University Press:  06 August 2010

William S. Price
William S. Price
Affiliation:
University of Western Sydney
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Summary

Introduction

This chapter is concerned with the practical issues and key considerations involved in setting up PGSE experiments and the subsequent data analysis. Selection of PGSE parameters is discussed in Section 6.2 and sample preparation is discussed in Section 6.3. The various methods of gradient calibration are considered in Section 6.4. Finally, PGSE data analysis and display are considered in Section 6.5. Under favourable conditions it is possible to measure diffusion coefficients with greater than 99% accuracy. Indeed simple PGSE experiments have been shown to be reasonably robust with respect to experimental parameters (e.g., rf pulse flip angle). It cannot be overemphasised that the overall accuracy of a diffusion measurement is intimately connected to the accuracy of the gradient calibration. It is too easy to confuse the apparent precision of a diffusion measurement obtained from analysing the PGSE data with the true overall accuracy. For example, the PGSE data obtained from an experiment may be highly single exponential, but the gradient calibration or temperature control may have been inaccurate such that the analysis of the PGSE data leads to a highly precise but unfortunately a highly inaccurate diffusion coefficient.

Irrespective of the aim of the PGSE experiment, the analysis is always simplified by starting with a distortion-free data set with good signal-to-noise and, especially when the system has multiple components, good resolution.

Type
Chapter
Information
NMR Studies of Translational Motion
Principles and Applications
 , pp. 198 - 220
Publisher: Cambridge University Press
Print publication year: 2009

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