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9 - The Future

Published online by Cambridge University Press:  13 July 2023

Richard B. Tenser
Affiliation:
Professor Emeritus of Pennsylvania State University
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Summary

Significant advances in the development of antiviral medications has come from efforts towardsthe control of human immunodeficiencyvirus (HIV), with nucleoside analogs and protease inhibitors leading the way. Similar are advances in vaccine development and understanding the immune system, including immune senescence with age. Antibodies will be used to directly treat illnesses and also to deliver medications including oligonucleotides to abnormal cells. Similarly, viruses have been used to deliver genes to human cells, including abnormal neurons to treat hitherto untreatable illnesses.

Development of methods to measure T lymphocyte functions will enhance understanding of human viral infections and autoimmune illnesses – both of which vary with age. Included in this will be the role of epigenetics on immune functions.

Understanding of latent virus infections of the nervous system will develop including the role of viral genes and also neuronal genes. Related will be understanding if neuronal damage and the development of the post-polio syndrome.

Type
Chapter
Information
Neurovirology
Measuring, Interpreting, and Understanding Viruses
, pp. 194 - 205
Publisher: Cambridge University Press
Print publication year: 2023

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References

Further Reading

Pollastro, S, deBourayne, M, Balzaretti, G, et al. Characterization and monitoring of antigen-responsive T cell clones using T cell receptor gene expression analysis. Front Immunol 2020;11:6096. https://doi.org/10.3389/fimmu.2020.609624Google ScholarPubMed
Rittiner, J, Moncalvo, M, Ckiba-falek, O, Kantor, B, Gene-editing technologies paired with viral vectors for translational research into neurodegenerative disorders. Front Mol Neurosci 2020;13:148. https://doi.org/10.3389/fnmol.2020.00148CrossRefGoogle Scholar
Tollefsbol, T, Handbook of Epigenetics, 3rd ed., Elsevier, 2022Google Scholar

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  • The Future
  • Richard B. Tenser, Professor Emeritus of Pennsylvania State University
  • Book: Neurovirology
  • Online publication: 13 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009235563.010
Available formats
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  • The Future
  • Richard B. Tenser, Professor Emeritus of Pennsylvania State University
  • Book: Neurovirology
  • Online publication: 13 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009235563.010
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • The Future
  • Richard B. Tenser, Professor Emeritus of Pennsylvania State University
  • Book: Neurovirology
  • Online publication: 13 July 2023
  • Chapter DOI: https://doi.org/10.1017/9781009235563.010
Available formats
×