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Chapter 29 - Neuroradiology: Focused Ultrasound in Neurosurgery

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press:  04 January 2024

By
Massimiliano Del Bene ,
Roberto Eleopra ,
Francesco Prada  and
Francesco DiMeco
Edited by
Farhana Akter ,
Nigel Emptage ,
Florian Engert  and
Mitchel S. Berger
Farhana Akter
Affiliation:
Harvard University, Massachusetts
Nigel Emptage
Affiliation:
University of Oxford
Florian Engert
Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger
Affiliation:
University of California, San Francisco
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Summary

Ultrasound(US) is a longitudinal mechanical wave characterized by a frequency higher than 20,000 Hz. US generation is possible because of the discovery of the piezoelectric effect by the Curie brothers in 1880 and the inverse effect by Gabriel Lippmann one year later. The first concrete application for piezoelectric technology was during World War I, when, in 1917, Paul Langevin developed an ultrasonic submarine detector. Progress has led to the introduction of piezoelectric technology in all sectors. Concerning medical applications, the most significant is represented by US-based imaging and treatment.

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Neuroscience for Neurosurgeons , pp. 382 - 397
Publisher: Cambridge University Press
Print publication year: 2024

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References

Alexandrov, AV, Demchuk, AM, Burgin, WS, Robinson, DJ, Grotta, JC. Ultrasound‐enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the CLOTBUST trial. J Neuroimaging 2004a;14:113–17.Google ScholarPubMed
Alexandrov, AV, Köhrmann, M, Soinne, L, et al. Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurol 2019;18:338–47. www.sciencedirect.com/science/article/pii/S1474442219300262.Google Scholar
Alexandrov, AV, Molina, CA, Grotta, JC, et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 2004b;351:2170–8.Google Scholar
Allen, SP, Prada, F, Xu, Z, et al. A preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation. Magn Reson Med 2021;85(4):2145–59. https://doi.org/10.1002/mrm.28537.CrossRefGoogle ScholarPubMed
Attal, N. Chronic neuropathic pain: mechanisms and treatment. Clin J Pain 2000;16:S118–30.CrossRefGoogle ScholarPubMed
Auboire, L, Sennoga, CA, Hyvelin, J-M, et al. Microbubbles combined with ultrasound therapy in ischemic stroke: a systematic review of in-vivo preclinical studies. PLoS One 2018;13:e0191788.CrossRefGoogle ScholarPubMed
Bilmin, K, Kujawska, T, Grieb, P. Sonodynamic therapy for gliomas. perspectives and prospects of selective sonosensitization of glioma cells. Cells 2019;8(11):1428. https://doi.org/10.3390/cells8111428.CrossRefGoogle ScholarPubMed
Bond, AE, Shah, BB, Huss, DS, et al. Safety and efficacy of focused ultrasound thalamotomy for patients with medication-refractory, tremor-dominant Parkinson disease: a randomized clinical trial. JAMA Neurol 2017;74:1412–8. https://doi.org/10.1001/jamaneurol.2017.3098.Google Scholar
Boutet, A, Gwun, D, Gramer, R, et al. The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound. J Neurosurg 2019;132(6):1785–91. https://doi.org/10.3171/2019.2.JNS182571.Google ScholarPubMed
Bunevicius, A, McDannold, NJ, Golby, AJ: Focused ultrasound strategies for brain tumor therapy. Oper Neurosurg 2020;19:9–18. https://doi.org/10.1093/ons/opz374.Google Scholar
Canney, MS, Chavrier, F, Tsysar, S, Chapelon, J-Y, Lafon, C, Carpentier, A. A multi-element interstitial ultrasound applicator for the thermal therapy of brain tumors. J Acoust Soc Am 2013;134:1647–55.CrossRefGoogle ScholarPubMed
Chang, JW, Park, CK, Lipsman, N, et al. A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: results at the 2-year follow-up. Ann Neurol 2018;83:107–14.CrossRefGoogle Scholar
Chapman, M, Park, A, Schwartz, M, Tarshis, J. Anesthesia considerations of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: a case series. Can J Anaesth 2020;67:877–84.Google Scholar
Chen, K-T, Wei, K-C, Liu, H-L. Theranostic strategy of focused ultrasound induced blood–brain barrier opening for CNS disease treatment. Front Pharmacol 2019;10:86. https://doi.org/10.3389/fphar.2019.00086.CrossRefGoogle ScholarPubMed
Chen, P-Y, Hsieh, H-Y, Huang, C-Y, Lin, C-Y, Wei, K-C, Liu, H-L. Focused ultrasound-induced blood–brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study. J Transl Med 2015a;13:93.Google Scholar
Chen, P-Y, Wei, K-C, Liu, H-L. Neural immune modulation and immunotherapy assisted by focused ultrasound induced blood–brain barrier opening. Hum Vaccin Immunother 2015b;11:2682–7.Google Scholar
Chen, Z, Xue, T, Huang, H, et al. Efficacy and safety of sonothombolysis versus non-sonothombolysis in patients with acute ischemic stroke: a meta-analysis of randomized controlled trials. PLoS One 2019;14:e0210516. https://doi.org/10.1371/journal.pone.0210516.Google Scholar
Christian, E, Yu, C, Apuzzo, MLJ. Focused ultrasound: relevant history and prospects for the addition of mechanical energy to the neurosurgical armamentarium. World Neurosurg 2014;82:354–65.Google Scholar
Cohen-Inbar, O, Xu, Z, Sheehan, JP. Focused ultrasound-aided immunomodulation in glioblastoma multiforme: a therapeutic concept. J Ther Ultrasound 2016;4:2.Google Scholar
Colloca, L, Ludman, T, Bouhassira, D, et al. Neuropathic pain. Nat Rev Dis Prim 2017;3:17002.Google Scholar
Coluccia, D, Fandino, J, Schwyzer, L, et al. First noninvasive thermal ablation of a brain tumor with MR-guided focused ultrasound. J Ther Ultrasound 2014;2:17. https://doi.org/10.1186/2050-5736-2-17.Google Scholar
Curley, CT, Sheybani, ND, Bullock, TN, Price, RJ. Focused ultrasound immunotherapy for central nervous system pathologies: challenges and opportunities. Theranostics 2017;7:3608–23. www.thno.org/v07p3608.htm.Google Scholar
D’Souza, AL, Tseng, JR, Pauly, KB, et al. A strategy for blood biomarker amplification and localization using ultrasound. Proc Natl Acad Sci U S A 2009;106:17152–7.Google Scholar
D’Souza, M, Chen, KS, Rosenberg, J, et al. Impact of skull density ratio on efficacy and safety of magnetic resonance-guided focused ultrasound treatment of essential tremor. J Neurosurg 2019;132(5):1392–7. https://doi.org/10.3171/2019.2.JNS183517.Google ScholarPubMed
Dalecki, D. Mechanical bioeffects of ultrasound. Annu Rev Biomed Eng 2004;6:229–48.Google Scholar
Dang, TTH, Rowell, D, Connelly, LB/ Cost-effectiveness of deep brain stimulation with movement disorders: a systematic review. Mov Disord Clin Pract 2019;6:348–58.Google Scholar
Darrow, DP. Focused ultrasound for neuromodulation. Neurotherapeutics 2019;16:88–99.Google Scholar
Davidson, B, Hamani, C, Rabin, JS, et al. Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials. Mol Psychiatry 2020;25:1946–57. https://doi.org/10.1038/s41380-020-0737-1.CrossRefGoogle ScholarPubMed
Deffieux, T, Younan, Y, Wattiez, N, Tanter, M, Pouget, P, Aubry, J-F. Low-intensity focused ultrasound modulates monkey visuomotor behavior. Curr Biol 2013;23:2430–3. https://doi.org/10.1016/j.cub.2013.10.029.Google Scholar
DeLong, MR, Wichmann, T. Basal ganglia circuits as targets for neuromodulation in Parkinson disease. JAMA Neurol 2015;72:1354–60.CrossRefGoogle ScholarPubMed
Deng, J, Huang, Q, Wang, F, et al. The role of caveolin-1 in blood–brain barrier disruption induced by focused ultrasound combined with microbubbles. J Mol Neurosci 2012;46:677–87. https://doi.org/10.1007/s12031-011-9629-9.CrossRefGoogle ScholarPubMed
Dixon, AJ, Li, J, Rickel, J-MR, Klibanov, AL, Zuo, Z, Hossack, JA. Efficacy of sonothrombolysis using microbubbles produced by a catheter-based microfluidic device in a rat model of ischemic stroke. Ann Biomed Eng 2019;47:1012–22.Google Scholar
Dobrakowski, PP, Machowska-Majchrzak, AK, Labuz-Roszak, B, Majchrzak, KG, Kluczewska, E, Pierzchała, KB. MR-guided focused ultrasound: a new generation treatment of Parkinson’s disease, essential tremor and neuropathic pain. Interv Neuroradiol 2014;20:275–82. https://doi.org/10.15274/INR-2014-10033.CrossRefGoogle ScholarPubMed
Donnan, GA, Fisher, M, Macleod, M, Davis, SM. Stroke. Lancet 2008;371:1612–23.Google Scholar
Dwedar, AZ, Ashour, S, Haroun, M, et al. Sonothrombolysis in acute middle cerebral artery stroke. Neurol India 2014;62:62–5. https://doi.org/10.4103/0028-3886.128308.Google Scholar
Ebani, EJ, Kaplitt, MG, Wang, Y, Nguyen, TD, Askin, G, Chazen, JL. Improved targeting of the globus pallidus interna using quantitative susceptibility mapping prior to MR-guided focused ultrasound ablation in Parkinson’s disease. Clin Imaging 2020;68:94–8.Google Scholar
Eggers, J, König, IR, Koch, B, Händler, G, Seidel, G. Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebral artery main stem occlusion: results from a randomized study. Stroke 2008;39:1470–5.CrossRefGoogle ScholarPubMed
Eggers, J, Seidel, G, Koch, B, König, IR. Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA. Neurology 2005;64:1052–4.CrossRefGoogle ScholarPubMed
Elias, WJ, Huss, D, Voss, T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2013;369:640–8.Google Scholar
Elias, WJ, Lipsman, N, Ondo, WG, et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2016;375:730–9. https://doi.org/10.1056/NEJMoa1600159.Google Scholar
Fan, C-H, Lin, C-Y, Liu, H-L, Yeh, C-K. Ultrasound targeted CNS gene delivery for Parkinson’s disease treatment. J Control Release 2017;261:246–62.CrossRefGoogle ScholarPubMed
Fiani, B, Lissak, IA, Soula, M, et al. The emerging role of magnetic resonance imaging-guided focused ultrasound in functional neurosurgery. Cureus 2020;12:e9820. https://doi.org/10.7759/cureus.9820.Google Scholar
Finley, DS, Pouliot, F, Shuch, B, et al. Ultrasound-based combination therapy: potential in urologic cancer. Expert Rev Anticancer Ther 2011;11:107–13.CrossRefGoogle ScholarPubMed
Foffani, G, Trigo-Damas, I, Pineda-Pardo, JA, et al. Focused ultrasound in Parkinson’s disease: a twofold path toward disease modification. Mov Disord 2019;34:1262–73.Google Scholar
Fomenko, A, Neudorfer, C, Dallapiazza, RF, Kalia, SK, Lozano, AM. Low-intensity ultrasound neuromodulation: an overview of mechanisms and emerging human applications. Brain Stimul 2018;11:1209–17. www.sciencedirect.com/science/article/pii/S1935861X18302961.CrossRefGoogle ScholarPubMed
Franzini, A, Moosa, S, Prada, F, Elias, WJ. Ultrasound ablation in neurosurgery: current clinical applications and future perspectives. Neurosurgery 2020;87:1–10.Google Scholar
Franzini, A, Moosa, S, Servello, D, et al. Ablative brain surgery: an overview. Int J Hyperthermia 2019;36:64–80. www.ncbi.nlm.nih.gov/pubmed/31537157.CrossRefGoogle ScholarPubMed
Frenkel, V, Kimmel, E, Iger, Y. Ultrasound-facilitated transport of silver chloride (AgCl) particles in fish skin. J Control Release 2000;68:251–61.Google Scholar
Frenkel, V, Etherington, A, Greene, M, et al. Delivery of liposomal doxorubicin (Doxil) in a breast cancer tumor model: investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure. Acad Radiol 2006;13:469–79. https://doi.org/10.1016/j.acra.2005.08.024.Google Scholar
Frenkel, V, Gurka, R, Liberzon, A, Shavit, U, Kimmel, E. Preliminary investigations of ultrasound induced acoustic streaming using particle image velocimetry. Ultrasonics 2001;39:153–6. https://doi.org/10.1016/s0041-624x(00)00064-0.CrossRefGoogle ScholarPubMed
Fry, WJ, Barnard, JW, Fry, EJ, Krumins, RF, Brennan, JF. Ultrasonic lesions in the mammalian central nervous system. Science 1955;122:517–8.Google Scholar
Fry, WJ, Meyers, R. Ultrasonic method of modifying brain structures. Confin Neurol 1962;22:315–27.Google Scholar
Fusco, P, De Sanctis, F, Di Carlo, S, et al. Dexmedetomidine sedation in magnetic resonance-guided focused ultrasound thalamotomy: a case series of 3 patients. A&A Pract 2019;12:406–08.Google Scholar
Gagliardo, C, Cannella, R, Quarrella, C, et al. Intraoperative imaging findings in transcranial MR imaging-guided focused ultrasound treatment at 1.5T may accurately detect typical lesional findings correlated with sonication parameters. Eur Radiol 2020;30:5059–70.CrossRefGoogle ScholarPubMed
Gallay, MN, Moser, D, Federau, C, Jeanmonod, D. Anatomical and technical reappraisal of the pallidothalamic tractotomy with the incisionless transcranial MR-guided focused ultrasound. A technical note. Front Surg 2019a;6:2.Google Scholar
Gallay, MN, Moser, D, Federau, C, Jeanmonod, D. Radiological and thermal dose correlations in pallidothalamic tractotomy with MRgFUS. Front Surg 2019b;6:28.Google Scholar
Gallay, MN, Moser, D, Jeanmonod, D. Safety and accuracy of incisionless transcranial MR-guided focused ultrasound functional neurosurgery: single-center experience with 253 targets in 180 treatments. J Neurosurg 2018;1–10. Online ahead of publication. https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2017.12.JNS172054.xml.Google Scholar
Gallay, MN, Moser, D, Rossi, F, et al. Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy. J Ther Ultrasound 2016;4:5.Google Scholar
Gallay, MN, Moser, D, Rossi, F, et al. MRgFUS Pallidothalamic tractotomy for chronic therapy-resistant Parkinson’s disease in 51 consecutive patients: single center experience. Front Surg 2019c;6:76.Google Scholar
Gerhardson, T, Sukovich, JR, Chaudhary, N, et al. Histotripsy clot liquefaction in a porcine intracerebral hemorrhage model. Neurosurgery 2020;86:429–36. https://doi.org/10.1093/neuros/nyz089.Google Scholar
Gerhardson, T, Sukovich, JR, Pandey, AS, Hall, TL, Cain, CA, Xu, Z. Effect of frequency and focal spacing on transcranial histotripsy clot liquefaction, using electronic focal steering. Ultrasound Med Biol 2017;43:2302–17.Google Scholar
Gersten, JW, Kawashima, E. Recent advances in fundamental aspects of ultrasound and muscle. Br J Phys Med 1955;18:106–09.Google Scholar
Giordano, M, Caccavella, VM, Zaed, I, et al. Comparison between deep brain stimulation and magnetic resonance-guided focused ultrasound in the treatment of essential tremor: a systematic review and pooled analysis of functional outcomes. J Neurol Neurosurg Psychiatry 2020;91(12):1270–8. https://doi.org/10.1136/jnnp-2020-323216.CrossRefGoogle ScholarPubMed
Guthkelch, AN, Carter, LP, Cassady, JR, et al. Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial. J Neurooncol 1991;10:271–84.CrossRefGoogle ScholarPubMed
Hancock, HA, Smith, LH, Cuesta, J, et al. Investigations into pulsed high-intensity focused ultrasound-enhanced delivery: preliminary evidence for a novel mechanism. Ultrasound Med Biol 2009;35:1722–36.CrossRefGoogle ScholarPubMed
Harnof, S, Zibly, Z, Hananel, A, et al. Potential of magnetic resonance-guided focused ultrasound for intracranial hemorrhage: an in vivo feasibility study. J Stroke Cerebrovasc Dis 2014;23:1585–91. www.sciencedirect.com/science/article/pii/S1052305713005612.CrossRefGoogle ScholarPubMed
Heimburger, RF. Ultrasound augmentation of central nervous system tumor therapy. Indiana Med 1985;78:469–76.Google Scholar
Hersh, DS, Kim, AJ, Winkles, JA, Eisenberg, HM, Woodworth, GF, Frenkel, V. Emerging applications of therapeutic ultrasound in neuro-oncology: moving beyond tumor ablation. Neurosurgery 2016;79:643–54. https://doi.org/10.1227/NEU.0000000000001399.Google Scholar
Hu, Z, Yang, XY, Liu, Y, et al. Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs. Biochem Biophys Res Commun 2005;335:124–31. https://doi.org/10.1016/j.bbrc.2005.07.071.Google Scholar
Hu, Z, Yang, XY, Liu, Y, et al. Investigation of HIFU-induced anti-tumor immunity in a murine tumor model. J Transl Med 2007;5:34. https://doi.org/10.1186/1479-5876-5-34.Google Scholar
Hynynen, K. Demonstration of enhanced temperature elevation due to nonlinear propagation of focussed ultrasound in dog’s thigh in vivo. Ultrasound Med Biol 1987;13:85–91. https://doi.org/10.1016/0301-5629(87)90078-0.Google Scholar
Hynynen, K, Clement, G. Clinical applications of focused ultrasound – the brain. Int J Hyperthermia 2007;23:193–202. https://doi.org/10.1080/02656730701200094.Google Scholar
Hynynen, K, Darkazanli, A, Unger, E, Schenck, JF. MRI-guided noninvasive ultrasound surgery. Med Phys 1993;20:107–15. https://doi.org/10.1118/1.597093.Google Scholar
Hynynen, K, Jolesz, FA. Demonstration of potential noninvasive ultrasound brain therapy through an intact skull. Ultrasound Med Biol 1998;24:275–83. https://doi.org/10.1016/s0301-5629(97)00269-x.CrossRefGoogle ScholarPubMed
Idbaih, A, Canney, M, Belin, L, et al. Safety and feasibility of repeated and transient blood–brain barrier disruption by pulsed ultrasound in patients with recurrent glioblastoma. Clin Cancer Res 2019;25:3793–801. https://doi.org/10.1158/1078-0432.CCR-18-3643.Google Scholar
Ilyas, A, Chen, C-J, Ding, D, et al. Magnetic resonance-guided, high-intensity focused ultrasound sonolysis: potential applications for stroke. Neurosurg Focus 2018;44:E12.Google Scholar
Ito, H, Yamamoto, K, Fukutake, S, Odo, T, Kamei, T. Two-year follow-up results of magnetic resonance imaging-guided focused ultrasound unilateral thalamotomy for medication-refractory essential tremor. Intern Med 2020;59:2481–3.Google Scholar
Jagannathan, J, Sanghvi, NT, Crum, LA, et al. High-intensity focused ultrasound surgery of the brain: part 1 – a historical perspective with modern applications. Neurosurgery 2009;64:201.CrossRefGoogle ScholarPubMed
James, JA, Dalton, GA, Bullen, MA, Freundlich, HF, Hopkins, JC. The ultrasonic treatment of Meniere’s disease. J Laryngol Otol 1960;74:730–57.Google Scholar
Jeanmonod, D, Werner, B, Morel, A, et al. Transcranial magnetic resonance imaging–guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain. Neurosurg Focus 2012;32(1):E1. https://doi.org/10.3171/2011.10.FOCUS11248.Google Scholar
Jones, RM, Kamps, S, Huang, Y, et al. Accumulated thermal dose in MRI-guided focused ultrasound for essential tremor: repeated sonications with low focal temperatures. J Neurosurg 2019;132(6):1802–9. https://doi.org/10.3171/2019.2.JNS182995.Google Scholar
Jung, HH, Chang, WS, Rachmilevitch, I, Tlusty, T, Zadicario, E, Chang, JW. Different magnetic resonance imaging patterns after transcranial magnetic resonance-guided focused ultrasound of the ventral intermediate nucleus of the thalamus and anterior limb of the internal capsule in patients with essential tremor or obsessive-com. J Neurosurg 2015b;122:162–8. https://doi.org/10.3171/2014.8.JNS132603.Google Scholar
Jung, HH, Kim, SJ, Roh, D, et al. Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study. Mol Psychiatry 2015a;20:1205–11. https://doi.org/10.1038/mp.2014.154.Google Scholar
Jung, NY, Chang, JW. Magnetic resonance-guided focused ultrasound in neurosurgery: taking lessons from the past to inform the future. J Korean Med Sci 2018;33:e279. https://doi.org/10.3346/jkms.2018.33.e279.Google Scholar
Jung, NY, Park, CK, Kim, M, Lee, PH, Sohn, YH, Chang, JW. The efficacy and limits of magnetic resonance-guided focused ultrasound pallidotomy for Parkinson’s disease: a Phase I clinical trial. J Neurosurg 2018; https://doi.org/10.3171/2018.2.JNS172514. Online ahead of print.Google Scholar
Kampinga, HH. Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field. Int J Hyperthermia 2006;22:191–6. https://doi.org/10.1080/02656730500532028.Google Scholar
Kapadia, AN, Elias, GJB, Boutet, A, et al. Multimodal MRI for MRgFUS in essential tremor: post-treatment radiological markers of clinical outcome. J Neurol Neurosurg Psychiatry 2020;91:921–7. https://doi.org/10.1136/jnnp-2020-322745.Google Scholar
Katz, M, Luciano, MS, Carlson, K, et al. Differential effects of deep brain stimulation target on motor subtypes in Parkinson’s disease. Ann Neurol 2015;77:710–9. https://doi.org/10.1002/ana.24374.Google Scholar
Katzir, S. Who knew piezoelectricity? Rutherford and Langevin on submarine detection and the invention of sonar. Notes Rec R Soc 2012;66:141–57. https://doi.org/10.1098/rsnr.2011.0049.Google Scholar
Keil, VC, Borger, V, Purrer, V, et al. MRI follow-up after magnetic resonance-guided focused ultrasound for non-invasive thalamotomy: the neuroradiologist’s perspective. Neuroradiology 2020;62:1111–22. https://doi.org/10.1007/s00234-020-02433-9.Google Scholar
Khokhlova, VA, Bailey, MR, Reed, JA, Cunitz, BW, Kaczkowski, PJ, Crum, LA. Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom. J Acoust Soc Am 2006;119:1834–48. https://doi.org/10.1121/1.2161440.Google Scholar
Kim, M, Jung, NY, Park, CK, Chang, WS, Jung, HH, Chang, JW. Comparative evaluation of magnetic resonance-guided focused ultrasound surgery for essential tremor. Stereotact Funct Neurosurg 2017;95:279–86. https://doi.org/10.1159/000478866.Google Scholar
Kim, SJ, Roh, D, Jung, HH, Chang, WS, Kim, C-H, Chang, JW. A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up. J Psychiatry Neurosci 2018;43:170188. https://doi.org/10.1503/jpn.170188.CrossRefGoogle Scholar
Kovacs, ZI, Kim, S, Jikaria, N, et al. Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation. Proc Natl Acad Sci U S A, 2017;114:E75–84.CrossRefGoogle ScholarPubMed
Krasovitski, B, Frenkel, V, Shoham, S, Kimmel, E. Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects. Proc Natl Acad Sci U S A 2011;108:3258–63.Google Scholar
Kuliha, M, Roubec, M, Jonszta, T, et al. Safety and efficacy of endovascular sonolysis using the EkoSonic endovascular system in patients with acute stroke. Am J Neuroradiol 2013;34:1401–06. www.ajnr.org/content/34/7/1401.abstract.Google Scholar
Lamsam, L, Johnson, E, Connolly, ID, Wintermark, M, Hayden Gephart, M. A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy. Neurosurg Focus 2018;44:E10.Google Scholar
Lehman, VT, Lee, KH, Klassen, BT, et al. MRI and tractography techniques to localize the ventral intermediate nucleus and dentatorubrothalamic tract for deep brain stimulation and MR-guided focused ultrasound: a narrative review and update. Neurosurg Focus 2020;49:E8.Google Scholar
Lepock, JR. Measurement of protein stability and protein denaturation in cells using differential scanning calorimetry. Methods 2005;35:117–25.Google Scholar
Lin, C-Y, Hsieh, H-Y, Chen, C-M, et al. Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood–brain barrier opening in Parkinson’s disease mouse model. J Control Release 2016;235:72–81. https://doi.org/10.1016/j.jconrel.2016.05.052.Google Scholar
Lionetti, V, Fittipaldi, A, Agostini, S, Giacca, M, Recchia, FA, Picano, E. Enhanced caveolae-mediated endocytosis by diagnostic ultrasound in vitro. Ultrasound Med Biol 2009;35:136–43. https://doi.org/10.1016/j.ultrasmedbio.2008.07.011.Google Scholar
Lipsman, N, Schwartz, ML, Huang, Y, et al. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol 2013;12:462–8.Google Scholar
Long, L, Cai, X, Guo, R, et al. Treatment of Parkinson’s disease in rats by Nrf2 transfection using MRI-guided focused ultrasound delivery of nanomicrobubbles. Biochem Biophys Res Commun 2017;482:75–80.Google Scholar
Louis, ED. Treatment of medically refractory essential tremor. N Engl J Med 2016;375:792–3. https://doi.org/10.1056/NEJMe1606517.Google Scholar
Louis, ED, Ottman, R. How many people in the USA have essential tremor? Deriving a population estimate based on epidemiological data.Tremor Other Hyperkinet Mov (N Y) 2014;4:259.Google Scholar
Lu, P, Zhu, X-Q, Xu, Z-L, Zhou, Q, Zhang, J, Wu, F. Increased infiltration of activated tumor-infiltrating lymphocytes after high intensity focused ultrasound ablation of human breast cancer. Surgery 2009;145:286–93.CrossRefGoogle ScholarPubMed
Lynn, JG, Zwemer, RL, Chick, AJ, Miller, AE. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol 1942;26:179–93. https://doi.org/10.1085/jgp.26.2.179.Google Scholar
Magara, A, Bühler, R, Moser, D, Kowalski, M, Pourtehrani, P, Jeanmonod, D. First experience with MR-guided focused ultrasound in the treatment of Parkinson’s disease. J Ther Ultrasound 2014;2:11.Google Scholar
Mainprize, T, Lipsman, N, Huang, Y, et al. Blood–brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: a clinical safety and feasibility study. Sci Rep 2019;9:321. https://doi.org/10.1038/s41598-018-36340-0.Google Scholar
Martin, E, Jeanmonod, D, Morel, A, Zadicario, E, Werner, B. High-intensity focused ultrasound for noninvasive functional neurosurgery. Ann Neurol 2009;66:858–61.Google Scholar
Martínez-Fernández, R, Pineda-Pardo, JA. Magnetic resonance-guided focused ultrasound for movement disorders: clinical and neuroimaging advances. Curr Opin Neurol 2020;33:488–97.Google Scholar
Martínez-Fernández, R, Rodríguez-Rojas, R, Del Álamo, M, et al. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson’s disease: a pilot study. Lancet Neurol 2018;17:54–63.CrossRefGoogle ScholarPubMed
Mauri, G, Nicosia, L, Xu, Z, et al. Focused ultrasound: tumour ablation and its potential to enhance immunological therapy to cancer. Br J Radiol 2018;91:20170641.CrossRefGoogle ScholarPubMed
McDannold, N, Clement, GT, Black, P, Jolesz, F, Hynynen, K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery 2010;66:323–32; discussion 332. https://doi.org/10.1227/01.NEU.0000360379.95800.2F.CrossRefGoogle ScholarPubMed
McDannold, NJ, Vykhodtseva, NI, Hynynen, K. Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology 2006;241:95–106.Google Scholar
McDannold, NJ, White, PJ, Cosgrove, GR. MRI-based thermal dosimetry based on single-slice imaging during focused ultrasound thalamotomy. Phys Med Biol: 2020a;65(23):235018. https://doi.org/10.1088/1361-6560/abb7c4.Google Scholar
McDannold, N, White, PJ, Cosgrove, GR. Using phase data from MR temperature imaging to visualize anatomy during MRI guided focused ultrasound neurosurgery. IEEE Trans Med Imaging 2020b;39(12):3821–30. https://doi.org/10.1109/TMI.2020.3005631.Google Scholar
Medel, R, Monteith, SJ, Elias, WJ, et al. Magnetic resonance-guided focused ultrasound surgery: Part 2: a review of current and future applications. Neurosurgery 2012;71:755–63.Google Scholar
Meng, Y, Pople, CB, Kalia, SK, et al. Cost-effectiveness analysis of MR-guided focused ultrasound thalamotomy for tremor-dominant Parkinson’s disease. J Neurosurg 2020. https://doi.org/10.3171/2020.5.JNS20692. Online ahead of print.Google Scholar
Meng, Y, Suppiah, S, Surendrakumar, S, Bigioni, L, Lipsman, N. Low-intensity MR-guided focused ultrasound mediated disruption of the blood–brain barrier for intracranial metastatic diseases. Front Oncol 2018;8:338. www.frontiersin.org/article/10.3389/fonc.2018.00338.Google Scholar
Metman, LV, Slavin, KV. Advances in functional neurosurgery for Parkinson’s disease. Mov Disord 2015;30:1461–70.Google Scholar
Miller, TR, Guo, S, Melhem, ER, et al. Predicting final lesion characteristics during MR-guided focused ultrasound pallidotomy for treatment of Parkinson’s disease. J Neurosurg 2020;134(3):1083–90. https://doi.org/10.3171/2020.2.JNS192590.Google Scholar
Molina, CA, Barreto, AD, Tsivgoulis, G, et al. Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial. Ann Neurol 2009;66:28–38.CrossRefGoogle ScholarPubMed
Molina, CA, Ribo, M, Rubiera, M, et al. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke 2006;37:425–9.Google Scholar
Monteith, SJ, Harnof, S, Medel, R, et al. Minimally invasive treatment of intracerebral hemorrhage with magnetic resonance-guided focused ultrasound. J Neurosurg 2013a;118:1035–45.Google Scholar
Monteith, SJ, Kassell, NF, Goren, O, Harnof, S. Transcranial MR-guided focused ultrasound sonothrombolysis in the treatment of intracerebral hemorrhage. Neurosurg Focus 2013b;34:E14.Google Scholar
Moosa, S, Martínez-Fernández, R, Elias, WJ, Del Alamo, M, Eisenberg, HM, Fishman, PS. The role of high-intensity focused ultrasound as a symptomatic treatment for Parkinson’s disease. Mov Disord 2019;34:1243–51. https://doi.org/10.1002/mds.27779.Google Scholar
N’Djin, WA, Burtnyk, M, Lipsman, N, et al. Active MR-temperature feedback control of dynamic interstitial ultrasound therapy in brain: in vivo experiments and modeling in native and coagulated tissues. Med Phys 2014;41:93301.Google Scholar
Nacu, A, Kvistad, CE, Naess, H, et al. NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study): randomized controlled contrast-enhanced sonothrombolysis in an unselected acute ischemic stroke population. Stroke 2017;48:335–41.Google Scholar
Nyborg, WL: Biological effects of ultrasound: development of safety guidelines. Part II: general review. Ultrasound Med Biol 2001;27:301–33.CrossRefGoogle ScholarPubMed
O’Brien, WD. Ultrasound – biophysics mechanisms. Prog Biophys Mol Biol 2007;93:212–55. https://pubmed.ncbi.nlm.nih.gov/16934858.Google Scholar
O’Neill, BE, Vo, H, Angstadt, M, Li, KPC, Quinn, T, Frenkel, V. Pulsed high intensity focused ultrasound mediated nanoparticle delivery: mechanisms and efficacy in murine muscle. Ultrasound Med Biol 2009;35:416–24.Google Scholar
Pacia, CP, Zhu, L, Yang, Y, et al. Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model. Sci Rep 2020;10:7449. https://doi.org/10.1038/s41598-020-64440-3.Google Scholar
Paff, M, Boutet, A, Neudorfer, C, et al. Magnetic resonance-guided focused ultrasound thalamotomy to treat essential tremor in nonagenarians. Stereotact Funct Neurosurg 2020;98:182–6. https://doi.org/10.1159/000506817.Google Scholar
Park, J, Jung, S, Jung, T, Lee, M. Focused ultrasound surgery for the treatment of recurrent anaplastic astrocytoma: a preliminary report. AIP Conf Proc 2006;829:238–40. https://aip.scitation.org/doi/abs/10.1063/1.2205473.Google Scholar
Park, SH, Kim, MJ, Jung, HH, et al. Safety and feasibility of multiple blood–brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy. J Neurosurg 2020. https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2019.10.JNS192206/article-10.3171-2019.10.JNS192206.xml. Online ahead of print.Google Scholar
Pouliopoulos, AN, Wu, S-Y, Burgess, MT, Karakatsani, ME, Kamimura, HAS, Konofagou, EE. A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer. Ultrasound Med Biol 2020;46:73–89.CrossRefGoogle ScholarPubMed
Prada, F, Franzini, A, Moosa, S, et al. In vitro and in vivo characterization of a cranial window prosthesis for diagnostic and therapeutic cerebral ultrasound. J Neurosurg 2020a. https://doi.org/10.3171/2019.10.JNS191674. Online ahead of print.Google Scholar
Prada, F, Kalani, MYS, Yagmurlu, K, et al. Applications of focused ultrasound in cerebrovascular diseases and brain tumors. Neurotherapeutics 2019;16:67–87. https://doi.org/10.1007/s13311-018-00683-3.Google Scholar
Prada, F, Sheybani, N, Franzini, A, et al. Fluorescein-mediated sonodynamic therapy in a rat glioma model. J Neurooncol 2020b;148:445–54. https://doi.org/10.1007/s11060-020-03536-2.Google Scholar
Ram, Z, Cohen, ZR, Harnof, S, et al. Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy. Neurosurgery 2006;59:946–9.Google Scholar
Ranjan, M, Boutet, A, Bhatia, S, et al. Neuromodulation beyond neurostimulation for epilepsy: scope for focused ultrasound. Expert Rev Neurother 2019a;19:937–43.Google Scholar
Ranjan, M, Elias, GJB, Boutet, A, et al. Tractography-based targeting of the ventral intermediate nucleus: accuracy and clinical utility in MRgFUS thalamotomy. J Neurosurg 2019b. https://doi.org/10.3171/2019.6.JNS19612. Online ahead of print.Google Scholar
Ricci, S, Dinia, L, Del Sette, M, et al. Sonothrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2012;10:CD008348.Google Scholar
Rodriguez-Rojas, R, Pineda-Pardo, JA, Martinez-Fernandez, R, et al. Functional impact of subthalamotomy by magnetic resonance-guided focused ultrasound in Parkinson’s disease: a hybrid PET/MR study of resting-state brain metabolism. Eur J Nucl Med Mol Imaging 2020;47:425–36. https://doi.org/10.1007/s00259-019-04497-z.Google Scholar
Rubiera, M, Ribo, M, Delgado-Mederos, R, et al. Do bubble characteristics affect recanalization in stroke patients treated with microbubble-enhanced sonothrombolysis? Ultrasound Med Biol 2008;34:1573–77.Google Scholar
Shah, BR, Lehman, VT, Kaufmann, TJ, et al. Advanced MRI techniques for transcranial high intensity focused ultrasound targeting. Brain 2020;143:2664–72.Google Scholar
Sharma, VD, Patel, M, Miocinovic, S. Surgical treatment of Parkinson’s disease: devices and lesion approaches. Neurotherapeutics 2020;17(4):1525–38. https://doi.org/10.1007/s13311-020-00939-x.Google Scholar
Sheehan, K, Sheehan, D, Sulaiman, M, et al. Investigation of the tumoricidal effects of sonodynamic therapy in malignant glioblastoma brain tumors. J Neurooncol 2020;148:9–16.Google Scholar
Sheikov, N, McDannold, N, Sharma, S, Hynynen, K. Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium. Ultrasound Med Biol 2008;34:1093–104. https://doi.org/10.1016/j.ultrasmedbio.2007.12.015.Google Scholar
Sheikov, N, McDannold, N, Vykhodtseva, N, Jolesz, F, Hynynen, K. Cellular mechanisms of the blood–brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 2004;30:979–89. https://doi.org/10.1016/j.ultrasmedbio.2004.04.010.Google Scholar
Sheybani, ND, Price, RJ. Perspectives on recent progress in focused ultrasound immunotherapy. Theranostics 2019;9:7749–58. https://doi.org/10.7150/thno.37131.Google Scholar
Sinai, A, Nassar, M, Eran, A, et al. Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience. J Neurosurg 2019. https://doi.org/10.3171/2019.3.JNS19466. Online ahead of print.Google Scholar
Skoloudik, D, Bar, M, Skoda, O, et al. Efficacy of sonothrombotripsy versus sonothrombolysis in recanalization of intracranial arteries. Eur J Neurol 2006;13:180.Google Scholar
Smith, AN, Fisher, GW, Macleod, IB, Preshaw, RM, Stavney, LS, Gordon, D. The effect of ultrasound on the gastric mucosa and its secretion of acid. Br J Surg 1966;53:720–5.Google Scholar
Sokka, SD, King, R, Hynynen, K. MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh. Phys Med Biol 2003;48:223–41.Google Scholar
Song, CW, Park, HJ, Lee, CK, Griffin, R. Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. Int J Hyperthermia 2005;21:761–7.Google Scholar
Su, JH, Choi, EY, Tourdias, T, et al. Improved VIM targeting for focused ultrasound ablation treatment of essential tremor: a probabilistic and patient-specific approach. Hum Brain Mapp 2020;41:4769–88.CrossRefGoogle ScholarPubMed
Suehiro, S, Ohnishi, T, Yamashita, D, et al. Enhancement of antitumor activity by using 5-ALA-mediated sonodynamic therapy to induce apoptosis in malignant gliomas: significance of high-intensity focused ultrasound on 5-ALA-SDT in a mouse glioma model. J Neurosurg 2018;129:1416–28. https://doi.org/10.3171/2017.6.JNS162398.Google Scholar
Tran, BC, Seo, Jongbum, Hall, TL, Fowlkes, JB, Cain, CA. Effects of contrast agent infusion rates on thresholds for tissue damage produced by single exposures of high-intensity ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 2005;52:1121–30. https://doi.org/10.1109/tuffc.2005.1503998.Google Scholar
Tsivgoulis, G, Alexandrov, AV. Ultrasound-enhanced thrombolysis in acute ischemic stroke: potential, failures, and safety. Neurotherapeutics 2007;4:420–7. https://doi.org/0.1016/j.nurt.2007.05.012.Google Scholar
Tyler, WJ, Tufail, Y, Finsterwald, M, Tauchmann, ML, Olson, EJ, Majestic, C. Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound. PLoS One 2008;3:e3511. https://doi.org/10.1371/journal.pone.0003511.Google Scholar
Vimeux, FC, De Zwart, JA, Palussiére, J, et al. Real-time control of focused ultrasound heating based on rapid MR thermometry. Invest Radiol 1999;34:190–3. https://doi.org/10.1097/00004424-199903000-00006.Google Scholar
Wahab, RA, Choi, M, Liu, Y, Krauthamer, V, Zderic, V, Myers, MR. Mechanical bioeffects of pulsed high intensity focused ultrasound on a simple neural model. Med Phys 2012;39:4274–83. https://doi.org/10.1118/1.4729712.Google Scholar
Walters, H, Shah, BB. Focused ultrasound and other lesioning therapies in movement disorders. Curr Neurol Neurosci Rep 2019;19:66. https://doi.org/10.1007/s11910-019-0975-2.Google Scholar
Wang, TR, Bond, AE, Dallapiazza, RF, et al. Transcranial magnetic resonance imaging-guided focused ultrasound thalamotomy for tremor: technical note. Neurosurg Focus 2018;44:E3.Google Scholar
Weidman, EK, Kaplitt, MG, Strybing, K, Chazen, JL. Repeat magnetic resonance imaging-guided focused ultrasound thalamotomy for recurrent essential tremor: case report and review of MRI findings. J Neurosurg 2019. https://doi.org/10.3171/2018.10.JNS181721. Online ahead of print.Google Scholar
Weintraub, D, Elias, WJ: The emerging role of transcranial magnetic resonance imaging-guided focused ultrasound in functional neurosurgery. Mov Disord 2017;32:20–7.Google Scholar
White, PJ, Zhang, Y-Z, Power, C, Vykhodtseva, N, McDannold, N. Observed effects of whole-brain radiation therapy on focused ultrasound blood–brain barrier disruption. Ultrasound Med Biol 2020;46:1998–2006. www.sciencedirect.com/science/article/pii/S030156292030185X.CrossRefGoogle ScholarPubMed
Wu, S-K, Santos, MA, Marcus, SL, Hynynen, K. MR-guided focused ultrasound facilitates sonodynamic therapy with 5-aminolevulinic acid in a rat glioma model. Sci Rep 2019;9:10465. https://doi.org/10.1038/s41598-019-46832-2.Google Scholar
Xu, Y, He, Q, Wang, M, et al. Safety and efficacy of magnetic resonance imaging-guided focused ultrasound neurosurgery for Parkinson’s disease: a systematic review. Neurosurg Rev 20219;44(1):115–27. https://doi.org/10.1007/s10143-019-01216-y.Google Scholar
Younan, Y, Deffieux, T, Larrat, B, Fink, M, Tanter, M, Aubry, J-F. Influence of the pressure field distribution in transcranial ultrasonic neurostimulation. Med Phys 2013;40:82902.Google Scholar
Yu, T, Li, SL, Zhao, JZ, Mason, TJ. Ultrasound: a chemotherapy sensitizer. Technol Cancer Res Treat 2006;5:51–60.Google Scholar
Yu, T, Wang, G, Hu, K, Ma, P, Bai, J, Wang, Z. A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound: a rabbit kidney study. Urol Res 2004;32:14–9.Google Scholar
Zafar, A, Quadri, SA, Farooqui, M, et al. MRI-guided high-intensity focused ultrasound as an emerging therapy for stroke: a review. J Neuroimaging 2019;29:5–13. https://doi.org/10.1111/jon.12568.Google Scholar
Zaki Ghali, MG, Srinivasan, VM, Kan, P. Focused ultrasonography-mediated blood–brain barrier disruption in the enhancement of delivery of brain tumor therapies. World Neurosurg 2019;131:65–75. https://doi.org/10.1016/j.wneu.2019.07.096.Google Scholar
Zhu, L, Nazeri, A, Pacia, CP, Yue, Y, Chen, H. Focused ultrasound for safe and effective release of brain tumor biomarkers into the peripheral circulation. PLoS One 2020;15:e0234182. https://doi.org/10.1371/journal.pone.0234182.Google Scholar

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