Of all areas of medicine, the practice of neurological prognostication requires one of the deepest understandings of the humanistic aspects of medicine.  Neurological injuries affect the most human aspects of a patient’s life – the ability to think, feel, talk, eat, and walk. The impact of neurological injuries must be considered in the context of a patient’s and their family’s cultural, moral, and religious beliefs.  Additionally, a patient’s geographical location influences their case from legal and social perspectives.  Neurological prognostication for a severely brain-injured patient is practiced in a very different way by a clinician at a major medical center in New York City caring for an Orthodox Jewish patient than it is by a clinician in Bangladesh caring for a Muslim patient. All neurological prognostication requires an intimate understanding of a patient’s ethical and religious beliefs and the local laws and customs.