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Case 1 - Amyotrophic Lateral Sclerosis (ALS)

from Disorders of the Anterior Horn Cell

Published online by Cambridge University Press:  aN Invalid Date NaN

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

While working is his garden, a 59-year-old man noticed pain in his neck and shoulders. He had some difficulty holding his head in an upright position and rising from a squat. The referring neurologist had performed an MRI scan of the cervical spine, which was normal. As his CK activity was moderately elevated and the EMG showed fibrillation potentials, myositis was suggested. On referral – six months after disease onset – he also mentioned difficulty climbing stairs. When walking, he experienced cramps in the calves. In recent weeks, he had developed a slurred speech and had problems fastening buttons. He had lost 10 kg (12% of his original weight). Pseudobulbar affect (forced laughter, yawning, or crying) was not mentioned at the time.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 71 - 76
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

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Oliver, D, Radunovic, A, Allen, A, McDermott, C. The development of the UK National Institute of Health and Care Excellence evidence-based clinical guidelines on motor neurone disease. Amyotroph Lateral Scler Frontotemporal Degener 2017;18 (5-6):313323. doi: 10.1080/21678421.2017.1304558. Epub 2017 May 17. PMID: 28513234.CrossRefGoogle ScholarPubMed
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