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11 - Potential therapies to limit obesity

Published online by Cambridge University Press:  15 September 2009

By
Jason C. G. Halford
Edited by
Jenni Harvey  and
Dominic J. Withers
Jason C. G. Halford
Affiliation:
School of Psychology, Eleanor Rathbone Building, Bedford Street, South University of Liverpool, Liverpool, L69 7ZA, UK
Jenni Harvey
Affiliation:
University of Dundee
Dominic J. Withers
Affiliation:
Imperial College of Science, Technology and Medicine, London
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Summary

The chapters within this book have detailed various aspects of the neurobiology of weight control. These include the genetic factors which determined the function of the body's energy regulation and the central mechanisms responsible for maintaining the body's energy balance. Particular focus has been placed on central targets such as the melanocortin and endogenous opioid systems. These systems represent two factors which control food intake: energy balance regulation and pleasure/reward. It is the metabolic demand for energy and the pleasure derived from eating palatable foods which determine when, what and how much we eat. Other chapters have dealt with peripheral generated signals such as ghrelin, leptin and insulin and their role in appetite and energy regulation. Such mechanisms provide episodic meal-by-meal signals of food consumption and the tonic signals of energy storage to the CNS. Organs such as the gut, the pancreas and adipose tissue act as both detectors and effectors in the organism energy regulation system. This diverse peripheral input allows the organism to constantly monitor its current energy status. In turn the CNS does not only adjust the expression of feeding behavior, as the last chapter shows the CNS also exerts control over the storage of energy.

Given the complexity of these systems underpinning energy regulation (episodic and tonic, peripheral and central) it may appear surprising that the state of obesity exists. However, despite the collective action of these many systems it seems many individuals experience great difficulty controlling their own body weight.

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Neurobiology of Obesity , pp. 302 - 319
Publisher: Cambridge University Press
Print publication year: 2008

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  • Potential therapies to limit obesity
    • By Jason C. G. Halford, School of Psychology, Eleanor Rathbone Building, Bedford Street, South University of Liverpool, Liverpool, L69 7ZA, UK
  • Edited by Jenni Harvey, University of Dundee, Dominic J. Withers, Imperial College of Science, Technology and Medicine, London
  • Book: Neurobiology of Obesity
  • Online publication: 15 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541643.012
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  • Potential therapies to limit obesity
    • By Jason C. G. Halford, School of Psychology, Eleanor Rathbone Building, Bedford Street, South University of Liverpool, Liverpool, L69 7ZA, UK
  • Edited by Jenni Harvey, University of Dundee, Dominic J. Withers, Imperial College of Science, Technology and Medicine, London
  • Book: Neurobiology of Obesity
  • Online publication: 15 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541643.012
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  • Potential therapies to limit obesity
    • By Jason C. G. Halford, School of Psychology, Eleanor Rathbone Building, Bedford Street, South University of Liverpool, Liverpool, L69 7ZA, UK
  • Edited by Jenni Harvey, University of Dundee, Dominic J. Withers, Imperial College of Science, Technology and Medicine, London
  • Book: Neurobiology of Obesity
  • Online publication: 15 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541643.012
Available formats
×