Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I Semantic Memory: Building Models from Lesions
- Part II Insights from Electrophysiology
- Part III Applications of Models to Understanding Cognitive Dysfunction
- Part IV Representations of Nouns and Verbs vs. Objects and Actions
- Part V Critical Role of Subcortical Nuclei in Semantic Functions
- Part VI Conceptual Models of Semantics
- Part 10 Process and content in semantic memory
- 11 The conceptual structure account: A cognitive model of semantic memory and its neural instantiation
- 12 Neural foundations for conceptual representations: Evidence from functional brain imaging
- 13 Neural hybrid model of semantic object memory (version 1.1)
- Index
- References
12 - Neural foundations for conceptual representations: Evidence from functional brain imaging
from Part VI - Conceptual Models of Semantics
Published online by Cambridge University Press: 14 September 2009
By
Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I Semantic Memory: Building Models from Lesions
- Part II Insights from Electrophysiology
- Part III Applications of Models to Understanding Cognitive Dysfunction
- Part IV Representations of Nouns and Verbs vs. Objects and Actions
- Part V Critical Role of Subcortical Nuclei in Semantic Functions
- Part VI Conceptual Models of Semantics
- Part 10 Process and content in semantic memory
- 11 The conceptual structure account: A cognitive model of semantic memory and its neural instantiation
- 12 Neural foundations for conceptual representations: Evidence from functional brain imaging
- 13 Neural hybrid model of semantic object memory (version 1.1)
- Index
- References
Summary
Overview
Semantic memory refers to a major division of declarative memory that includes knowledge of the meaning of objects and words. This chapter will focus on one aspect of the functional neuroanatomy of semantic memory: the representation of the meaning of concrete objects and object properties. The initial motivation for our work on this topic was reports of patients with so-called category-specific knowledge disorders – specifically, patients with relatively selective impaired knowledge about animals and other animate objects, and those with relatively selective impairments for man-made, inanimate objects such as tools. Since the publication of the seminal case studies by Warrington and colleagues (Warrington & McCarthy, 1983; Warrington & Shallice, 1984), well over 100 patients have been reported with a category-specific deficit for biological categories (living things, especially four-legged animals), relative to inanimate objects (especially tools and other artifacts), and more than 25 cases with the opposite pattern of deficit (Capitani et al., 2003). Our work has been motivated by an appreciation of the importance of these clinical cases for understanding the organization of conceptual knowledge, object recognition, and storage of long-term memories. In this chapter I shall outline a model of how conceptual knowledge about concrete entities (objects) is organized in the brain based on functional brain imaging studies of normal, intact individuals. From a theoretical perspective, the model attempts to incorporate the main features of property-based models that have dominated thinking about category-specific disorders for over one hundred years, and the challenge to this view from the Domain Specific theory (Caramazza & Shelton, 1998; for an overview of recent theories of the organization of conceptual knowledge in the brain see Caramazza, 1998; Martin & Caramazza, 2003).
Keywords
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- Neural Basis of Semantic Memory , pp. 302 - 330Publisher: Cambridge University PressPrint publication year: 2007
References
(2001). The neurobiology of social cognition. Current Opinion in Neurobiology, 11: 231–9.CrossRefGoogle ScholarPubMed
, , , , and (2002). Analysis of the neuronal selectivity underlying low fMRI signals. Current Biology, 12: 964–72.CrossRefGoogle ScholarPubMed
, , , , and (2005). Dissociable controlled retrieval and generalized selection mechanisms in ventrolateral prefrontal cortex. Neuron, 47: 907–18.CrossRefGoogle ScholarPubMed
, , , and (1999). An fMRI version of the Farnsworth–Munsell 100-Hue test reveals multiple color-selective areas in human ventral occipitotemporal cortex. Cerebral Cortex, 9: 257–63.CrossRefGoogle ScholarPubMed
. and (in press). Grounding object concepts in perception and action: evidence from fMRI studies of tools. Cortex.Google Scholar
, , , and (2002). Parallel visual motion processing streams for manipulable objects and human movements. Neuron, 34: 149–59.CrossRefGoogle ScholarPubMed
, , , and (2003). fMRI responses to video and point-light displays of moving humans and manipulable objects. Journal of Cognitive Neuroscience, 15: 991–1001.CrossRefGoogle ScholarPubMed
(2002). Functional MRI of language: new approaches to understanding the cortical organization of semantic processing. Annual Review of Neuroscience, 25: 151–88.CrossRefGoogle ScholarPubMed
, , , and (2003). What are the facts of semantic category-specific deficits? A critical review of the clinical evidence. Cognitive Neuropsychology, 20: 213–61.CrossRefGoogle ScholarPubMed
(1998). The interpretation of semantic category-specific deficits: what do they reveal about the organization of conceptual knowledge in the brain? Introduction. Neurocase, 4: 265–72.CrossRefGoogle Scholar
and (2003). The organization of conceptual knowledge: the evidence from category-specific semantic deficits. Trends in Cognitive Sciences, 7: 354–61.CrossRefGoogle ScholarPubMed
and (1998). Domain-specific knowledge systems in the brain the animate–inanimate distinction. Journal of Cognitive Neuroscience, 10: 1–34.CrossRefGoogle ScholarPubMed
, , , and (2000). Movement and mind: a functional imaging study of perception and interpretation of complex intentional movement patterns. NeuroImage, 12: 314–25.CrossRefGoogle ScholarPubMed
and (1999). Cortical representation of perception, naming, and knowledge of color. Journal of Cognitive Neuroscience, 11: 25–35.CrossRefGoogle Scholar
and (2000). Representation of manipulable man-made objects in the dorsal stream. NeuroImage, 12: 478–84.CrossRefGoogle ScholarPubMed
, , and (1999a). Attribute-based neural substrates in temporal cortex for perceiving and knowing about objects. Nature Neuroscience, 2: 913–19.CrossRefGoogle Scholar
, , and (1999b). Are face-responsive regions selective only for faces?Neuroreport, 10: 2945–50.CrossRefGoogle Scholar
, , and (2002). Experience-dependent modulation of category-related cortical activity. Cerebral Cortex, 12: 545–51.CrossRefGoogle ScholarPubMed
, , , , , , and (2000). The visual word form area – spatial and temporal characterization of an initial stage of reading in normal subjects and posterior split-brain patients. Brain, 123: 291–307.CrossRefGoogle ScholarPubMed
and (2003). Functional magnetic resonance imaging (fMRI) “brain reading”: detecting and classifying distributed patterns of fMRI activity in human visual cortex. Neuroimage, 19: 261–70.CrossRefGoogle ScholarPubMed
, , and (2004). Contextually evoked object-specific responses in human visual cortex. Science, 304: 115–17.CrossRefGoogle ScholarPubMed
and (2003). The selective impairment of fruit and vegetable knowledge: A multiple processing channels account of fine-grain category specificity. Cognitive Neuropsychology, 20: 355–72.CrossRefGoogle ScholarPubMed
(1989). Time-locked multiregional retroactivation: a systems-level proposal for the neural substrates of recall and recognition. Cognition, 33: 25–62.CrossRefGoogle ScholarPubMed
(1991). Two systems for colour-naming defects: verbal disconnection vs colour imagery disorder. Neuropsychologia, 29: 1–18.CrossRefGoogle ScholarPubMed
., ., ., ., and , (1999). Sources of mathematical thinking: behavioral and brain-imaging evidence. Science, 284: 970–4.CrossRefGoogle ScholarPubMed
(1996). Neural mechanisms for visual memory and their role in attention. Proceedings of the National Academy of Sciences USA, 93: 13494–9.CrossRefGoogle ScholarPubMed
, , , , , , and (1997). A functional MRI study of mental image generation. Neuropsychologia, 35: 725–30.CrossRefGoogle ScholarPubMed
, , and (2005). Category-related activation for written words in the posterior fusiform is task specific. Neuropsychologia, 43: 69–74.CrossRefGoogle ScholarPubMed
, , , , , , and (1997). How the brain learns to see objects and faces in an impoverished context. Nature, 389: 596–9.CrossRefGoogle Scholar
and (1998). A cortical representation of the local visual environment. Nature, 392: 598–601.CrossRefGoogle ScholarPubMed
and (2005). The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey. Journal of Comparative Neurology, 486: 295–317.CrossRefGoogle ScholarPubMed
, , and (1998). The role of left prefrontal cortex in language and memory. Proceedings of the National Academy of Sciences USA, 95: 906–13.CrossRefGoogle ScholarPubMed
, , , , , and (2006). Dissociation of automatic and strategic lexical–semantics: fMRI evidence for differing roles of mid-IT and multiple frontal regions. Journal of Neuroscience, 26, 6523–32.CrossRefGoogle Scholar
and (2001). fMR-adaptation: a tool for studying the functional properties of human cortical neurons. Acta Psychologica, 107: 293–321.CrossRefGoogle ScholarPubMed
, , and (2006). Repetition and the brain: Neural models of stimulus-specific effects. Trends in Cognitive Science, 10: 14–23.CrossRefGoogle ScholarPubMed
and (2001). Brain activity evoked by inverted and imagined biological motion. Vision Research, 41: 1475–82.CrossRefGoogle ScholarPubMed
and (2002). Brain areas active during visual perception of biological motion. Neuron, 35: 1167–75.CrossRefGoogle ScholarPubMed
, , , , , and (2001). Distributed and overlapping representations of faces and objects in ventral temporal cortex. Science, 293: 2425–30.CrossRefGoogle ScholarPubMed
and (1944). An experimental study of apparent behavior. American Journal of Psychology, 57: 243–9.CrossRefGoogle Scholar
(2003). Neuroimaging studies of priming. Progress in Neurobiology, 70: 53–81.CrossRefGoogle ScholarPubMed
, , , , , , , , , , and (1998). The functional anatomy of imagining and perceiving colour. Neuroreport, 9: 1019–23.CrossRefGoogle ScholarPubMed
, , and (2000). Distributed neural systems for the generation of visual images. Neuron, 28: 979–90.CrossRefGoogle ScholarPubMed
, , , and (1995). Grasping objects: the cortical mechanisms of visuomotor transformation. Trends in Neurosciences, 18: 314–20.CrossRefGoogle ScholarPubMed
(2004). The neural bases of complex tool use in humans. Trends in Cognitive Sciences, 8: 71–8.CrossRefGoogle ScholarPubMed
(2001). Functional neuroimaging studies of category specificity in object recognition: A critical review and meta-analysis. Cognitive, Affective, & Behavioral Neuroscience, 1: 119–36.CrossRefGoogle ScholarPubMed
, , , , and (2003). Role of mental imagery in a property verification task: fMRI evidence for perceptual representations of conceptual knowledge. Cognitive Neuropsychology, 20: 525–40.CrossRefGoogle Scholar
, , and (1999). The fusiform face area is selective for faces not animals. Neuroreport, 10: 183–7.CrossRefGoogle Scholar
, , , and (1997). A locus in human extrastriate cortex for visual shape analysis. Journal of Cognitive Neuroscience, 9: 133–42.CrossRefGoogle ScholarPubMed
, , , , , and (2002). Object activation from features in the semantic system. Journal of Cognitive Neuroscience, 14: 24–36.CrossRefGoogle ScholarPubMed
and . (2003). Constraining questions about the organisation and representation of conceptual knowledge. Cognitive Neuropsychology, 20: 433–50.CrossRefGoogle ScholarPubMed
, , and (2002). The topography of high-order human object areas. Trends in Cognitive Science, 6: 176–84.CrossRefGoogle ScholarPubMed
, , , , , , , , , and (1995). Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex. Proceedings of the National Academy of Sciences USA, 92: 8135–9.CrossRefGoogle ScholarPubMed
Martin, A. (1998). The organization of semantic knowledge and the origin of words in the brain. In and (eds.), The Origins and Diversification of Language. San Francisco: California Academy of Sciences, pp. 69–98.Google Scholar
(2001). Functional neuroimaging of semantic memory. In R. Cabeza and A. Kingstone (eds.), Handbook of Functional NeuroImaging of Cognition. Cambridge: MIT Press, pp. 153–86.Google Scholar
and (2003). Neuropsychological and neuroimaging perspectives on conceptual knowledge: an introduction. Cognitive Neuropsychology, 20: 195–212.CrossRefGoogle Scholar
and (2001). Semantic memory and the brain: structure and processes. Current Opinion in Neurobiology, 11: 194–201.CrossRefGoogle ScholarPubMed
and (2003). Neural foundations for understanding social and mechanical concepts. Cognitive Neuropsychology, 20: 575–87.CrossRefGoogle ScholarPubMed
, , , , and (1995). Discrete cortical regions associated with knowledge of color and knowledge of action. Science, 270: 102–5.CrossRefGoogle Scholar
, , , and (1996). Neural correlates of category-specific knowledge. Nature, 379: 649–52.CrossRefGoogle ScholarPubMed
, , and (2002). Distinct neural systems subserve person and object knowledge. Proceedings of the National Academy of Sciences USA, 99: 15238–43.CrossRefGoogle ScholarPubMed
, , , and (2006). Two distinct neural mechanisms for category-selective responses. Cerebral Cortex, 16: 437–45.CrossRefGoogle ScholarPubMed
and (2000). Mental imagery of faces and places activates corresponding stimulus-specific brain regions. Journal of Cognitive Neuroscience, 12: 1013–23.CrossRefGoogle Scholar
and (1994). Responses of anterior superior temporal polysensory (STPa) neurons to “biological motion” stimuli. Journal of Cognitive Neuroscience, 6: 99–116.CrossRefGoogle ScholarPubMed
, , , , , , , and (1995). The physiology of coloured hearing. A PET activation study of colour–word synaesthesia. Brain, 118: 661–76.CrossRefGoogle ScholarPubMed
, , , , and (1988). Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature, 331: 585–9.CrossRefGoogle ScholarPubMed
and (1998). The neural development and organization of letter recognition: evidence from functional neuroimaging, computational modeling, and behavioral studies. Proceedings of the National Academy of Science USA, 95: 847–52.CrossRefGoogle ScholarPubMed
, ., ., and (2003). How is the fusiform gyrus related to category-specificity?Cognitive Neuropsychology, 20: 561–74.CrossRefGoogle Scholar
, , , , and (1998). Temporal cortex activation in humans viewing eye and mouth movements. Journal of Neuroscience, 18: 2188–99.CrossRefGoogle ScholarPubMed
, , and (2003). Representing tools: how two non-human primate species distinguish between the functionally relevant and irrelevant features of a tool. Animal Cognition, 6: 269–81.CrossRefGoogle Scholar
, , , , , , and (2003). The role of the fusiform face area in social cognition: implications for the pathobiology of autism. Philosophical Transactions of the Royal Society of London Series B – Biological Sciences, 358: 415–27.CrossRefGoogle ScholarPubMed
, , and (2006). Cortical signatures of noun and verb production. Proceedings of the National Academy of Sciences USA, 103: 1644–9.CrossRefGoogle ScholarPubMed
, , , and (1996). Preserved color imagery in an achromatopsic. Neuropsychologia, 34: 485–9.CrossRefGoogle Scholar
, ., and (2005). Pictures of appetizing foods activate gustatory cortices for taste and reward. Cerebral Cortex, 15: 1602–8.CrossRefGoogle ScholarPubMed
, , , , , and (2006). A common neural substrate for perceiving and knowing about color. Neuropsychologia, in press.Google Scholar
and (2002). How distributed is visual category information in human occipito-temporal cortex? An fMRI study. Neuron, 35: 1157–65.CrossRefGoogle ScholarPubMed
(2003). Neuroimaging studies of semantic memory: inferring “how” from “where”. Neuropsychologia, 41: 280–92.CrossRefGoogle Scholar
, , and (1997). A neural basis for the retrieval of conceptual knowledge. Neuropsychologia, 35: 1319–27.CrossRefGoogle ScholarPubMed
, , , , and (2003). Neural correlates of conceptual knowledge for actions. Cognitive Neuropsychology, 20: 409–32.CrossRefGoogle ScholarPubMed
, , and (2000). Long-lasting cortical plasticity in the object naming system. Nature Neuroscience, 3: 1329–34.CrossRefGoogle ScholarPubMed
, , and (in press). A neural system for learning about object function. Cerebral Cortex, published on-line March 31, 2006, doi: 10.1093/cercor/bhj 176.Google Scholar
, , , and (2002). Dissociable brain regions process object meaning and object structure during picture naming. Neuropsychologia, 40: 174–86.CrossRefGoogle ScholarPubMed
., ., , and (2005). Automatic priming of semantically related words reduces activity in the fusiform gyrus. Journal of Cognitive Neuroscience, 17: 1871–85.CrossRefGoogle ScholarPubMed
, , and (1999). Neural correlates of semantic and episodic memory retrieval. Neuropsychologia, 37: 103–18.CrossRefGoogle ScholarPubMed
, , , , , , and (2000). Noun imageability and the temporal lobes. Neuropsychologia, 38: 985–94.CrossRefGoogle ScholarPubMed
Yang, J. J., Francis, N., Bellgowan, P. S. F., and Martin, A, (2005). Object concepts and the human amygdala: Enhanced activity for identifying animals independent of input modality and stimulus format. Presented at Cognitive Neuroscience Society Annual Meeting, New York.
and (2004). Face perception: domain specific, not process specific. Neuron, 44: 889–98.Google Scholar
, , , , , and (1991). A direct demonstration of functional specialization in human visual cortex. Journal of Neuroscience, 11: 641–9.CrossRefGoogle ScholarPubMed
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