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7 - Neonatal hemolysis

from Section II - Erythrocyte disorders

Published online by Cambridge University Press:  05 February 2013

Pedro de Alarcón
Affiliation:
University of Illinois College of Medicine
Eric Werner
Affiliation:
Children's Hospital of the King's Daughters
Robert D. Christensen
Affiliation:
McKay-Dee Hospital, Utah
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Summary

This chapter focuses on the recognition and management of hemolysis in newborn infants (Table 7.1). Some of the common hemolytic anemias of childhood first appear in the newborn period, while others do not present until several months of age, and a few rare hemolytic disorders occur only in the neonatal period. These variations in the age that hemolytic anemia first presents reflect differences in neonatal erythropoiesis, hemoglobin synthesis, and the metabolism of newborn erythrocytes. When approaching an infant with a potential hemolytic disorder, the first issue to be addressed is whether there is evidence of increased red cell destruction and accelerated production. If yes, then the next question is to consider whether the cause of neonatal hemolysis is due to extracellular (acquired) factors or an intrinsic (genetic) red cell defect. Acquired disorders are those that are immune-mediated, associated with infection, or accompany some other underlying pathology. Inherited red cell disorders are due to defects in the cell membrane, abnormalities in red blood cell (RBC) metabolism, or a consequence of a hemoglobin defect.

Evaluation of a neonate for hemolysis must be considered in the context of normal newborn physiology. The RBC lifespan in term neonates (80–100 days) and in premature infants (60–80 days) is shorter than in older children and adults (100–120 days) (1). The reason for the reduced RBC survival observed in newborns is not known, although there are many biochemical differences between adult and neonatal RBCs (2–4). Increased oxidant sensitivity of newborn red cells and relative instability of fetal hemoglobin have been considered as possible causes for this shortened lifespan (5). To date, a definitive explanation of the “normal” shortened RBC lifespan of infant red cells remains elusive.

Type
Chapter
Information
Neonatal Hematology
Pathogenesis, Diagnosis, and Management of Hematologic Problems
, pp. 91 - 117
Publisher: Cambridge University Press
Print publication year: 2013

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