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Memantine

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Memantine (1-amino-3,5-dimethyladamantane hydrochloride) is a white to off-white fine powder or a clear and colourless to light yellowish solution, with a molecular weight of 215.76 and an empirical formula of C12H21 N•HCl.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Moreau, C, Delval, A, Tiffreau, V, Defebvre, L, Dujardin, K, Duhamel, A, Petyt, G, Hossein-Foucher, C, Blum, D, Sablonnière, B, Schraen, S, Allorge, D, Destée, A, Bordat, R, Devos, D. Memantine for axial signs in Parkinson’s disease: a randomised, double-blind, placebo-controlled pilot study. J Neurol Neurosurg Psychiatry 2013; 84(5): 552555.CrossRefGoogle ScholarPubMed
Ondo, WG, Shinawi, L, Davidson, A, D Lai, . Memantine for non-motor features of Parkinson’s disease: a double-blind placebo controlled exploratory pilot trial. Parkinsonism Relat Disord 2011; 17(3): 156159.CrossRefGoogle ScholarPubMed
Wang, HF, Yu, JT, Tang, SW, Jiang, T, Tan, CC, Meng, XF, Wang, C, Tan, MS, Tan, L. Efficacy and safety of cholinesterase inhibitors and memantine in cognitive impairment in Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies: systematic review with meta-analysis and trial sequential analysis. J Neurol Neurosurg Psychiatry 2015; 86(2): 135143.CrossRefGoogle ScholarPubMed

References

Aarsland, D, Ballard, C, Walker, Z, Bostrom, F, Alves, G, Kossakowski, K, Leroi, I, Pozo-Rodriguez, F, Minthon, L, Londos, E. Memantine in patients with Parkinson’s disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol 2009; 8(7): 613618.CrossRefGoogle Scholar
AHFS Drug information, 2012. Bethesda: American Society of Health-System Pharmacists. Accessed on 19 July 2022 via www.medicinescomplete.com.Google Scholar
Emre, M, Tsolaki, M, Bonuccelli, U, Destée, A, Tolosa, E, Kutzelnigg, A, Ceballos-Baumann, A, Zdravkovic, S, Bladström, A, Jones, R ; 11018 Study Investigators. Memantine for patients with Parkinson’s disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2010; 9(10): 969977.CrossRefGoogle ScholarPubMed
Gomolin, IH, Smith, C, Jeitner, TM. Once-daily memantine: pharmacokinetic and clinical considerations. J Am Geriatr Soc 2010; 58(9): 18121813. https://cdpc.sydney.edu.au/wp-content/uploads/2019/06/deprescribing-guideline.pdf.CrossRefGoogle ScholarPubMed
Joint Formulary Committee. British National Formulary (online). London: BMJ Group and Pharmaceutical Press. Accessed on 19 July 2022 via www.medicinescomplete.com.Google Scholar
Kavirajan, H. Memantine: a comprehensive review of safety and efficacy. Expert Opin Drug Saf 2009; 8(1): 89109.CrossRefGoogle ScholarPubMed
Kawashima, S, Matsukawa, N. Memantine for the patients with mild cognitive impairment in Parkinson’s disease: a pharmacological fMRI study. BMC Neurol 2022; 22(1): 175.CrossRefGoogle Scholar
Kuns, B, Rosani, A, Varghese, V. Memantine. [Updated 2022 May 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Available from: www.ncbi.nlm.nih.gov/books/NBK500025/Google Scholar
Leroi, I, Overshott, R, Byrne, EJ, Daniel, E, Burns, A. Randomized controlled trial of memantine in dementia associated with Parkinson’s disease. Mov Disord 2009; 24(8): 12171221.CrossRefGoogle ScholarPubMed
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Rogawski, MA, Wenk, GL. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer’s disease. CNS Drug Rev 2003; 9(3): 275308.CrossRefGoogle ScholarPubMed
Summary of Product Characteristics – Ebixa 10 mg film-coated tablets. Lundbeck Limited. Electronic Medicines Compendium: Ebixa 10 mg film-coated tablets – summary of product characteristics (SmPC) – (emc). Accessed on 19 July 2022 via www.medicines.org.uk.Google Scholar
Varanese, S, Howard, J, Di Rocco, A. NMDA antagonist memantine improves levodopa-induced dyskinesias and “on-off” phenomena in Parkinson’s disease. Mov Disord 2010; 25(4):508510.CrossRefGoogle ScholarPubMed
Vidal, EI, Fukushima, FB, Valle, AP, Villas Boas, PJF. Unexpected improvement in levodopa-induced dyskinesia and on-off phenomena after introduction of memantine for treatment of Parkinson’s disease dementia. J Am Geriatr Soc 2013; 61(1): 170172.CrossRefGoogle ScholarPubMed
Wesnes, KA, Aarsland, D, Ballard, C, Londos, E. Memantine improves attention and episodic memory in Parkinson’s disease dementia and dementia with Lewy bodies. Int J Geriatr Psychiatry 2015; 30(1): 4654.CrossRefGoogle ScholarPubMed

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  • Memantine
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.028
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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Memantine
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.028
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Memantine
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.028
Available formats
×