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Levodopa, Inhaled

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri ,
Peter Jenner ,
Valentina Leta ,
Shelley Jones  and
Iro Boura
K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Levodopa ((2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid, 3,4-dihydroxy-l-phenylalanine) has a molecular weight of 197.19 and a molecular formula of C9H11NO4.

Type
Chapter
Information
The Movement Disorders Prescriber's Guide to Parkinson's Disease , pp. 220 - 228
Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Grosset, DG, Dhall, R, Gurevich, T, Kassubek, J, Poewe, WH, Rascol, O, Rudzinska, M, Cormier, J, Sedkov, A, Oh, C. Inhaled levodopa in Parkinson’s disease patients with OFF periods: a randomized 12-month pulmonary safety study. Parkinsonism Relat Disord 2020; 71: 4–10.CrossRefGoogle ScholarPubMed
Hauser, RA, Isaacson, SH, Ellenbogen, A, Safirstein, BE, Truong, DD, Komjathy, SF, Kegler-Ebo, DM, Zhao, P, Oh, C. Orally inhaled levodopa (CVT-301) for early morning OFF periods in Parkinson’s disease. Parkinsonism Relat Disord 2019; 64: 175–180.CrossRefGoogle Scholar
LeWitt, PA, Hauser, RA, Pahwa, R, Isaacson, SH, Fernandez, HH, Lew, M, Saint-Hilaire, M, Pourcher, E, Lopez-Manzanares, L, Waters, C, Rudzínska, M, Sedkov, A, Batycky, R, Oh, C. Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Neurol 2019; 18(2): 145–154.CrossRefGoogle ScholarPubMed

References

Hampson, NB, Kieburtz, KD, LeWitt, PA, Leinonen, M, Freed, MI. Prospective evaluation of pulmonary function in Parkinson’s disease patients with motor fluctuations. Int J Neurosci 2017; 127(3): 276–284.CrossRefGoogle ScholarPubMed
Levodopa. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 11 March 2023 via www.medicinescomplete.com.Google Scholar
Levodopa. In: DRUGDEX® System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Accessed on 11 March 2023 via www.micromedexsolutions.com.Google Scholar
LeWitt, PA, Pahwa, R, Sedkov, A, Corbin, A, Batycky, R, Murck, H. Pulmonary safety and tolerability of inhaled levodopa (CVT-301) Administered to Patients with Parkinson’s disease. J Aerosol Med Pulm Drug Deliv 2018; 31(3): 155–161.CrossRefGoogle ScholarPubMed
Lipp, MM, Batycky, R, Moore, J, Leinonen, M, Freed, MI. Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s disease. Sci Transl Med 2016; 8(360): 360ra136.CrossRefGoogle ScholarPubMed

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