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Entacapone

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Entacapone ((E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide) has a molecular weight of 305.29 and a molecular formula of C14H15N3O5.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Li, J, Lou, Z, Liu, X, Sun, Y, Chen, J. Efficacy and safety of adjuvant treatment with entacapone in advanced Parkinson’s disease with motor fluctuation: a systematic meta-analysis. Eur Neurol 2017; 78(3–4): 143153.CrossRefGoogle ScholarPubMed
Müller, T. Entacapone. Expert Opin Drug Metab Toxicol 2010; 6(8): 983993.CrossRefGoogle ScholarPubMed
Schrag, A. Entacapone in the treatment of Parkinson’s disease. Lancet Neurol 2005; 4(6): 366370.CrossRefGoogle ScholarPubMed

References

AHFS Drug information, 2012. Bethesda: American Society of Health-System Pharmacists. Accessed on 17 June 2021 via www.medicinescomplete.com.Google Scholar
Brooks, DJ, Sagar, H.. Entacapone is beneficial in both fluctuating and non-fluctuating patients with Parkinson’s disease: a randomised, placebo controlled, double blind, six month study. J Neurol Neurosurg Psychiatry 2003; 74(8): 10711079.CrossRefGoogle ScholarPubMed
Brusa, L, Bassi, A, Lunardi, G, Fedele, E, Peppe, A, Stefani, A, Pasqualetti, P, Stanzione, P, Pierantozzi, M. Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. Eur J Neurol 2004; 11(9): 593606.CrossRefGoogle ScholarPubMed
Entacapone. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 17 June 2022 via www.medicinescomplete.com.Google Scholar
Entacapone. In: DRUGDEX® System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Accessed on 3 March 2023 via www.micromedexsolutions.com.Google Scholar
Joint Formulary Committee. British National Formulary (online). London: BMJ Group and Pharmaceutical Press. Accessed on 17 June 2022 via www.medicinescomplete.com.Google Scholar
Larsen, JP, Worm-Petersen, J, Sidén, A, Gordin, A, Reinikainen, K, Leinonen, M. The tolerability and efficacy of entacapone over 3 years in patients with Parkinson’s disease. Eur J Neurol 2003; 10(2): 137146.CrossRefGoogle ScholarPubMed
Olanow, CW, Kieburtz, K, Stern, M, Watts, R, Langston, JW, Guarnieri, M, Hubble, J. Double-blind, placebo-controlled study of entacapone in levodopa-treated patients with stable Parkinson disease. Arch Neurol 2004; 61(10): 15631568.CrossRefGoogle Scholar
Parkinson Study Group. Entacapone improves motor fluctuations in levodopa-treated Parkinson’s disease patients. Ann Neurol 1997; 42(5): 747755.CrossRefGoogle Scholar
Poewe, WH, Deuschl, G, Gordin, A, Kultalahti, ER, Leinonen, M. Efficacy and safety of entacapone in Parkinson’s disease patients with suboptimal levodopa response: a 6-month randomized placebo-controlled double-blind study in Germany and Austria (Celomen study). Acta Neurol Scand 2002; 105(4): 245255.CrossRefGoogle ScholarPubMed
Rinne, UK, Larsen, JP, Siden, A, Worm-Petersen, J. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. Nomecomt Study Group. Neurology 1998; 51(5): 13091314.CrossRefGoogle ScholarPubMed
Summary of product characteristics – Comtess 200 mg film-coated tablets. Orion Pharma (UK) Ltd. Electronic Medicines Compendium: Comtess 200 mg film-coated tablets – Summary of product characteristics (SmPC) – (emc). Accessed on 3 March 2023 via www.medicines.org.uk.Google Scholar

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  • Entacapone
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.016
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  • Entacapone
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.016
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Entacapone
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.016
Available formats
×