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Apomorphine Hydrochloride Sublingual Film

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri ,
Peter Jenner ,
Valentina Leta ,
Shelley Jones  and
Iro Boura
K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Apomorphine hydrochloride (6aβ-aporphine-10,11-diol hydrochloride hemihydrate; (R)-10,11-dihydroxy-6a-aporphine hydrochloride hemihydrate; (6aR)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride hemihydrate) has a molecular weight of 303.8 and a molecular formula of C17H18ClNO2.

Type
Chapter
Information
The Movement Disorders Prescriber's Guide to Parkinson's Disease , pp. 49 - 56
Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Carbone, F, Djamshidian, A, Seppi, K, Poewe, W. Apomorphine for Parkinson’s disease: efficacy and safety of current and new formulations. CNS Drugs 2019; 33(9): 905–918. doi: 10.1007/s40263-019-00661-z. PMID: 31473980; PMCID: PMC6776563.CrossRefGoogle ScholarPubMed
Olanow, CW, Factor, SA, Espay, AJ, Hauser, RA, Shill, HA, Isaacson, S, Pahwa, R, Leinonen, M, Bhargava, P, Sciarappa, K, Navia, B, Blum, D ; CTH-300 Study investigators. Apomorphine sublingual film for off episodes in Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 study. Lancet Neurol 2020; 19(2): 135–144. doi: 10.1016/S1474-4422(19)30396-5. Epub 2019 Dec 7. PMID: 31818699.CrossRefGoogle ScholarPubMed
Titova, N, Chaudhuri, KR. Apomorphine therapy in Parkinson’s and future directions. Parkinsonism Relat Disord 2016; 33(Suppl 1): S56–S60. doi: 10.1016/j.parkreldis.2016.11.013. Epub 2016 Nov 30. PMID: 27913125.CrossRefGoogle ScholarPubMed

References

Apomorphine. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 5 December 2022 via www.medicinescomplete.com.Google Scholar
Apomorphine. In: DRUGDEX® System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Accessed on 5 December 2022 via www.micromedexsolutions.com.Google Scholar
Chaudhuri, KR, Todorova, A, Nirenberg, MJ, Parry, M, Martin, A, Martinez-Martin, P, Rizos, A, Henriksen, T, Jost, W, Storch, A, Ebersbach, G, Reichmann, H, Odin, P, Antonini, A. Pilot Prospective, A, Multicenter Observational Study of Dopamine Agonist Withdrawal Syndrome in Parkinson’s Disease. Mov Disord Clin Pract. 2015 Mar 16;2(2):170–174. doi:10.1002/mdc3.12141.PMID:30713891;PMCID:PMC6353371.CrossRefGoogle ScholarPubMed
Jenkins, JR, Pearce, JMS. Paradoxical akinetic response to apomorphine in parkinsonism. J Neurol Neurosurg Psychiatry 1992; 55: 414–415.CrossRefGoogle ScholarPubMed
Stocchi, F, De Pandis, MF, Delfino, FA, Anselmo, T, Frangillo, D. Transient atrial fibrillation after subcutaneous apomorphine bolus. Mov Disord 1996; 11: 584–585.CrossRefGoogle ScholarPubMed

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