This chapter helps fill a significant gap in the human sciences and professional practice, as theories of life meaning are both few in number and somewhat narrow in scope despite the scientifically and personally compelling nature of the topic. For those focused explicitly on motivating self and others, it opens new horizons for understanding how to elevate human experience under both favorable and adverse circumstances, consistent with the goal of creating a comprehensive theory of motivation and optimal functioning. It does so by explaining not only the nature and antecedents of feelings of life meaning but also that such feelings are facilitated and enhanced by TSP motivational patterns. Life meaning can thus provide humans with the motivational strength needed to overcome major life challenges and obstacles by telling us that “life is worth living” and “these goals are worth pursuing.”