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Chapter 9 - Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders

from Section 3 - Functional and Neurochemical Brain Studies

Published online by Cambridge University Press:  12 January 2021

By
Estêvão Scotti-Muzzi ,
Maria Concepcion Garcia Otaduy ,
Márcio Gerhardt Soeiro-de-Souza  and
Rodrigo Machado-Vieira
Edited by
Sudhakar Selvaraj ,
Paolo Brambilla  and
Jair C. Soares
Sudhakar Selvaraj
Affiliation:
UTHealth School of Medicine, USA
Paolo Brambilla
Affiliation:
Università degli Studi di Milano
Jair C. Soares
Affiliation:
UT Harris County Psychiatric Center, USA
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Summary

Glutamate (Glu) and gamma-aminobutyric acid (GABA) are the main brain excitatory and inhibitory neurotransmitters. These neurotransmitters are involved in neural migration, differentiation, and synaptic plasticity (1–6). There are accumulating evidence in literature that the neurobiology of mood disorders may arise from an imbalance between excitatory Glu (7–11) and inhibitory GABA (12–15) in key brain regions involved in mood regulation, such as the anterior cingulate cortex (ACC).

Type
Chapter
Information
Mood Disorders
Brain Imaging and Therapeutic Implications
 , pp. 105 - 120
Publisher: Cambridge University Press
Print publication year: 2021

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