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Preface

Published online by Cambridge University Press:  11 September 2009

G. Eric Blair
Affiliation:
University of Leeds
Craig R. Pringle
Affiliation:
University of Warwick
D. John Maudsley
Affiliation:
University of Warwick
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Summary

While the association of particular major histocompatibility complex (MHC) haplotypes with human diseases has been extensively reviewed, we felt that the area of modulation of MHC antigen expression and its association with human and animal diseases was less well explored. These ideas were initially exchanged between the editors and some of the authors of this book at a most interesting meeting organized by the British Society for Immunology in Warwick in 1991 entitled ‘Viruses, Cytokines and the MHC’. Following this meeting, we realised that there was a need for a broad, interdisciplinary treatment of the area of MHC modulation that would be useful for both basic medical researchers and clinicians.

Expression of MHC class I and class II antigens follows a complex pathway from gene transcription to plasma membrane insertion and many steps can be stimulated or repressed leading to altered levels of cell surface MHC molecules. Therefore, to provide basic background information on the MHC, the genomic organization, antigen structure, biosynthesis and function and control of transcription of class I and II are considered first along with the important effects which cytokines and other extracellular agents can have on MHC antigen expression. Infection and oncogenic transformation of mammalian cells by viruses have provided powerful systems for analysing precise mechanisms of MHC antigen modulation and the relationship of this process to disease.

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Publisher: Cambridge University Press
Print publication year: 1995

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  • Preface
  • Edited by G. Eric Blair, University of Leeds, Craig R. Pringle, University of Warwick, D. John Maudsley, University of Warwick
  • Book: Modulation of MHC Antigen Expression and Disease
  • Online publication: 11 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511525339.001
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  • Preface
  • Edited by G. Eric Blair, University of Leeds, Craig R. Pringle, University of Warwick, D. John Maudsley, University of Warwick
  • Book: Modulation of MHC Antigen Expression and Disease
  • Online publication: 11 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511525339.001
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Preface
  • Edited by G. Eric Blair, University of Leeds, Craig R. Pringle, University of Warwick, D. John Maudsley, University of Warwick
  • Book: Modulation of MHC Antigen Expression and Disease
  • Online publication: 11 September 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511525339.001
Available formats
×