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Chapter 21 - The Future of Computer-Assisted Semen Analysis in the Evaluation of Male Infertility

from Section 4 - Laboratory Evaluation and Treatment of Male Infertility

Published online by Cambridge University Press:  06 December 2023

By
David Mortimer  and
Sharon T. Mortimer
Edited by
Douglas T. Carrell ,
Alexander W. Pastuszak  and
James M. Hotaling
Douglas T. Carrell
Affiliation:
Utah Center for Reproductive Medicine
Alexander W. Pastuszak
Affiliation:
University of Utah
James M. Hotaling
Affiliation:
Utah Center for Reproductive Medicine
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Summary

This chapter reviews the current limitations of CASA in routine clinical andrology and describes a path by which it could become a robust analytical technology that can be employed in accredited expert clinical andrology laboratories. Particular focus is on the need for premarketing validation by manufacturers for CASA-based semen analysis applications, as well as the impact that software differences have on the absolute values reported for sperm kinematics. Without close comparability between CASA systems it will continue to be extremely difficult to establish either decision limits or reference ranges that can be applied clinically for either diagnostic or prognostic purposes.

Keywords

sperm motilitykinematicscomputer-aided sperm analysisCASAsperm function testssperm morphologysperm vitality
Type
Chapter
Information
Men's Reproductive and Sexual Health Throughout the Lifespan
An Integrated Approach to Fertility, Sexual Function, and Vitality
 , pp. 165 - 174
Publisher: Cambridge University Press
Print publication year: 2023

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References

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