Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- Part I Pharmacology of Cannabis and the Endocannabinoid System
- Part II The Changing Face of Cannabis
- Part III Cannabis and the Brain
- Part IV Cannabis, Anxiety, and Mood
- Chapter 11 Cannabis and Anxiety
- Chapter 12 Cannabis Consumption and Risk of Depression and Suicidal Behaviour
- Chapter 13 Cannabis and Bipolar Disorder
- Part V Cannabis and Psychosis
- Part VI Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VII Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VIII Special Topics
- Index
- References
Chapter 12 - Cannabis Consumption and Risk of Depression and Suicidal Behaviour
from Part IV - Cannabis, Anxiety, and Mood
Published online by Cambridge University Press: 12 May 2023
Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- Part I Pharmacology of Cannabis and the Endocannabinoid System
- Part II The Changing Face of Cannabis
- Part III Cannabis and the Brain
- Part IV Cannabis, Anxiety, and Mood
- Chapter 11 Cannabis and Anxiety
- Chapter 12 Cannabis Consumption and Risk of Depression and Suicidal Behaviour
- Chapter 13 Cannabis and Bipolar Disorder
- Part V Cannabis and Psychosis
- Part VI Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VII Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VIII Special Topics
- Index
- References
Summary
A plethora of studies in animal models and large epidemiological studies in humans have shown that cannabis consumption during adolescence – a critical neurodevelopmental period for human beings – leads to an increased risk of developing mood disorders in adolescence or in young adulthood. Cannabis interacts with the monoaminergic system and with the endogenous cannabinoid system by altering the mechanism of mood regulation. Recent meta-analyses have also pointed out an increased risk for major depression in young adulthood after cannabis consumption in adolescence, even in the absence of pre-existing depression. Moreover, cannabis is also a risk factor for suicidal behaviours and suicide attempts. In summary, clinical studies suggest that cannabis is consumed by young people with depression largely for self-medication; however, its use, even in the absence of pre-morbid conditions, may also increase the risk of developing a mood disorder and can drive impulsive and suicidal behaviours.
- Type
- Chapter
- Information
- Marijuana and Madness , pp. 120 - 127Publisher: Cambridge University PressPrint publication year: 2023
References
American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association.Google Scholar
Assari, S., Lankarani, M. M., and Caldwell, C. H. (2018). Does discrimination explain high risk of depression among high-income African American men? Behav Sci, 8, 40.Google Scholar
Bagge, C. L., and Borges, G. (2017). Acute substance use as a warning sign for suicide attempts: A case-crossover examination of the 48 hours prior to a recent suicide attempt. J Clin Psychiatry, 78, 20169.Google Scholar
Baggio, S, N’Goran, A. A., Deline, S, et al. (2014). Patterns of cannabis use and prospective associations with health issues among young males. Addiction, 109, 937–945.CrossRefGoogle ScholarPubMed
Bahorik, A. L., Leibowitz, A., Sterling, S. A., et al. (2017). Patterns of marijuana use among psychiatry patients with depression and its impact on recovery. J Affect Disord, 213, 168–171.Google Scholar
Bambico, F. R., Katz, N., Debonnel, G., et al. (2007). Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex. J Neurosci, 27, 11700–11711.CrossRefGoogle ScholarPubMed
Borges, G., Bagge, C. L., and Orozco, R. (2016). A literature review and meta-analyses of cannabis use and suicidality. J Affect Disord, 195, 63–74.Google Scholar
Bradvik, L. (2018). Suicide risk and mental disorders. Int J Environ Res Public Health, 15, 2028.Google Scholar
Briere, F. N., Fallu, J. S., Descheneaux, A., et al. (2011). Predictors and consequences of simultaneous alcohol and cannabis use in adolescents. Addict Behav, 36, 785–788.Google Scholar
Brook, D. W., Brook, J. S., Zhang, C., et al. (2002). Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders. Arch Gen Psychiatry, 59, 1039–1044.Google Scholar
Brook, J. S., Brook, D. W., Arencibia-Mireles, O., et al. (2001). Risk factors for adolescent marijuana use across cultures and across time. J Genet Psychol, 162, 357–374.Google Scholar
Caldeira, K. M., O’Grady, K. E., Vincent, K. B., et al. (2012). Marijuana use trajectories during the post-college transition: Health outcomes in young adulthood. Drug Alcohol Depend, 125, 267–275.CrossRefGoogle ScholarPubMed
Crane, N. A., Langenecker, S. A., and Mermelstein, R. J. (2015). Gender differences in the associations among marijuana use, cigarette use, and symptoms of depression during adolescence and young adulthood. Addict Behav, 49, 33–39.CrossRefGoogle ScholarPubMed
Cuttler, C., Spradlin, A., and McLaughlin, R. J. (2018). A naturalistic examination of the perceived effects of cannabis on negative affect. J Affect Disord, 235, 198–205.Google Scholar
D’Amico, E. J., Tucker, J. S., Miles, J. N., et al. (2016). Alcohol and marijuana use trajectories in a diverse longitudinal sample of adolescents: Examining use patterns from age 11 to 17 years. Addiction, 111, 1825–1835.Google Scholar
De Gregorio, D., Dean Conway, J., Canul, M. L., et al. (2020). Effects of chronic exposure to low doses of Delta9-tetrahydrocannabinol in adolescence and adulthood on serotonin/norepinephrine neurotransmission and emotional behaviors. Int J Neuropsychopharmacol, 23, 751–761.CrossRefGoogle ScholarPubMed
Degenhardt, L., Coffey, C., Carlin, J. B., et al. (2010). Outcomes of occasional cannabis use in adolescence: 10-year follow-up study in Victoria, Australia. Br J Psychiatry, 196, 290–295.CrossRefGoogle ScholarPubMed
Degenhardt, L., Coffey, C., Romaniuk, H., et al. (2013). The persistence of the association between adolescent cannabis use and common mental disorders into young adulthood. Addiction, 108, 124–133.Google Scholar
Delforterie, M. J., Lynskey, M. T., Huizink, A. C., et al. (2015). The relationship between cannabis involvement and suicidal thoughts and behaviors. Drug Alcohol Depend, 150, 98–104.CrossRefGoogle ScholarPubMed
Epstein, M., Hill, K. G., Nevell, A. M., et al. (2015). Trajectories of marijuana use from adolescence into adulthood: Environmental and individual correlates. Dev Psychol, 51, 1650–1663.CrossRefGoogle ScholarPubMed
Fergusson, D. M., and Horwood, L. (1997). Early onset cannabis use and psychosocial adjustment in young adults. Addiction, 92, 279–296.Google Scholar
Fergusson, D. M., Horwood, L. J., and Swain‐Campbell, N. (2002). Cannabis use and psychosocial adjustment in adolescence and young adulthood. Addiction, 97, 1123–1135.Google Scholar
Fleming, C. B., Mason, W. A., Mazza, J. J., et al. (2008). Latent growth modeling of the relationship between depressive symptoms and substance use during adolescence. Psychol Addict Behav, 22, 186–197.Google Scholar
Georgiades, K., and Boyle, M. H. (2007). Adolescent tobacco and cannabis use: Young adult outcomes from the Ontario Child Health Study. J Child Psychol Psychiatry, 48, 724–731.CrossRefGoogle ScholarPubMed
Gobbi, G., Atkin, T., Zytynski, T., et al. (2019). Association of cannabis use in adolescence and risk of depression, anxiety, and suicidality in young adulthood: A systematic review and meta-analysis. JAMA Psychiatry, 76, 426–434.Google Scholar
Han, B., Compton, W. M., Einstein, E. B., et al. (2021). Associations of suicidality trends with cannabis use as a function of sex and depression status. JAMA Netw Open, 4, e2113025.Google Scholar
Harder, V. S., Stuart, E. A., and Anthony, J. C. (2008). Adolescent cannabis problems and young adult depression: Male–female stratified propensity score analyses. Am J Epidemiol, 168, 592–601.Google Scholar
Jacobus, J., Squeglia, L., Escobar, S., et al. (2017). Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users. Psychopharmacology, 234, 3431–3442.Google Scholar
Ketcherside, A., and Filbey, F. M. (2015). Mediating processes between stress and problematic marijuana use. Addict Behav, 45, 113–118.Google Scholar
Kung, H. C., Pearson, J. L., and Liu, X. (2003). Risk factors for male and female suicide decedents ages 15–64 in the United States. Results from the 1993 National Mortality Followback Survey. Soc Psychiatry Psychiatr Epidemiol, 38, 419–426.Google Scholar
Kung, H. C., Pearson, J. L., and Wei, R. (2005). Substance use, firearm availability, depressive symptoms, and mental health service utilization among white and African American suicide decedents aged 15 to 64 years. Ann Epidemiol, 15, 614–621.CrossRefGoogle ScholarPubMed
Leadbeater, B. J., Ames, M. E., and Linden-Carmichael, A. N. (2019). Age-varying effects of cannabis use frequency and disorder on symptoms of psychosis, depression and anxiety in adolescents and adults. Addiction, 114, 278–293.Google Scholar
Lev-Ran, S., Roerecke, M., Le Foll, B., et al. (2014). The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies. Psychol Med, 44, 797–810.Google Scholar
Mammen, G., Rueda, S., Roerecke, M., et al. (2018). Association of cannabis with long-term clinical symptoms in anxiety and mood disorders: A systematic review of prospective studies. J Clin Psychiatry, 79, 2248.Google Scholar
Manrique-Garcia, E., Zammit, S., Dalman, C., et al. (2012). Cannabis use and depression: A longitudinal study of a national cohort of Swedish conscripts. BMC Psychiatry, 12, 112.Google Scholar
Marmorstein, N. R., and Iacono, W. G. (2011). Explaining associations between cannabis use disorders in adolescence and later major depression: A test of the psychosocial failure model. Addict Behav, 36, 773–776.Google Scholar
Meier, M. H., Hill, M. L., Small, P. J., et al. (2015). Associations of adolescent cannabis use with academic performance and mental health: A longitudinal study of upper middle class youth. Drug Alcohol Depend, 156, 207–212.Google Scholar
Moitra, E., Christopher, P. P., Anderson, B. J., et al. (2015). Coping-motivated marijuana use correlates with DSM-5 cannabis use disorder and psychological distress among emerging adults. Psychol Addict Behav, 29, 627–632.CrossRefGoogle ScholarPubMed
Moore, T. H., Zammit, S., Lingford-Hughes, A., et al. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review. Lancet, 370, 319–328.CrossRefGoogle ScholarPubMed
Orri, M., Seguin, J. R., Castellanos-Ryan, N., et al. (2021). A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Mol Psychiatry, 26, 5061–5070.Google Scholar
Otten, R., and Engels, R. C. (2013). Testing bidirectional effects between cannabis use and depressive symptoms: Moderation by the serotonin transporter gene. Addict Biol, 18, 826–835.CrossRefGoogle ScholarPubMed
van Ours, J. C., Williams, J., Fergusson, D., et al. (2013). Cannabis use and suicidal ideation. J Health Econ, 32, 524–537.Google Scholar
Patton, G. C., Coffey, C., Carlin, J. B., et al. (2002). Cannabis use and mental health in young people: Cohort study. BMJ, 325, 1195–1198.Google Scholar
Pistis, M., Perra, S., Pillolla, G., et al. (2004). Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons. Biol Psychiatry, 56, 86–94.Google Scholar
Price, C., Hemmingsson, T., Lewis, G., et al. (2009). Cannabis and suicide: Longitudinal study. Br J Psychiatry, 195, 492–497.CrossRefGoogle ScholarPubMed
Rhew, I. C., Fleming, C. B., Vander Stoep, A., et al. (2017). Examination of cumulative effects of early adolescent depression on cannabis and alcohol use disorder in late adolescence in a community-based cohort. Addiction, 112, 1952–1960.Google Scholar
Rubino, T., and Parolaro, D. (2016). The impact of exposure to cannabinoids in adolescence: Insights from animal models. Biol Psychiatry, 79, 578–585.CrossRefGoogle ScholarPubMed
Rubino, T., Prini, P., Piscitelli, F., et al. (2015). Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex. Neurobiol Dis, 73, 60–69.Google Scholar
Rubino, T., Realini, N., Braida, D., et al. (2009). Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus, 19, 763–772.CrossRefGoogle ScholarPubMed
Schoeler, T., Theobald, D., Pingault, J. B., et al. (2018). Developmental sensitivity to cannabis use patterns and risk for major depressive disorder in mid-life: Findings from 40 years of follow-up. Psychol Med, 48, 2169–2176.Google Scholar
Scholes-Balog, K. E., Hemphill, S. A., Evans-Whipp, T. J., et al. (2016). Developmental trajectories of adolescent cannabis use and their relationship to young adult social and behavioural adjustment: A longitudinal study of Australian youth. Addict Behav, 53, 11–18.Google Scholar
Shalit, N., Shoval, G., Shlosberg, D., et al. (2016). The association between cannabis use and suicidality among men and women: A population-based longitudinal study. J Affect Disord, 205, 216–224.Google Scholar
Silins, E., Horwood, L. J., Patton, G. C., et al. (2014). Young adult sequelae of adolescent cannabis use: An integrative analysis. Lancet Psychiatry, 1, 286–293.Google Scholar
Smolkina, M., Morley, K. I., Rijsdijk, F., et al. (2017). Cannabis and depression: A twin model approach to co-morbidity. Behav Genet, 47, 394–404.Google Scholar
Van Gastel, W. A., Vreeker, A., Schubart, C. D., et al. (2014). Change in cannabis use in the general population: A longitudinal study on the impact on psychotic experiences. Schizophr Res, 157, 266–270.Google Scholar
Wilkinson, A. L., Halpern, C. T., and Herring, A. H. (2016). Directions of the relationship between substance use and depressive symptoms from adolescence to young adulthood. Addict Behav, 60, 64–70.CrossRefGoogle ScholarPubMed
Windle, M., and Wiesner, M. (2004). Trajectories of marijuana use from adolescence to young adulthood: Predictors and outcomes. Devel Psychopathol, 16, 1007–1027.Google Scholar
Womack, S. R., Shaw, D. S., Weaver, C. M., et al. (2016). Bidirectional associations between cannabis use and depressive symptoms from adolescence through early adulthood among at-risk young men. J Stud Alcohol Drugs, 77, 287-297.Google Scholar
Zhang, X., and Wu, L. T. (2014). Suicidal ideation and substance use among adolescents and young adults: A bidirectional relation? Drug Alcohol Depend, 142, 63–73.Google Scholar