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Chapter 9 - Health of Children Born after Intracytoplasmic Sperm Injections (ICSI)

Published online by Cambridge University Press:  02 December 2021

By
Shahad Sabti  and
Alastair G. Sutcliffe
Edited by
Gianpiero D. Palermo  and
Zsolt Peter Nagy
Gianpiero D. Palermo
Affiliation:
Cornell Institute of Reproductive Medicine, New York
Zsolt Peter Nagy
Affiliation:
Reproductive Biology Associates, Atlanta, GA
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Summary

Intracytoplasmic sperm injection (ICSI) is currently the most commonly used assisted reproductive technology (ART) for management of male-factor infertility. Being a relatively new and invasive procedure, limited data are available with regards to the perinatal, neonatal and long-term health of children born as a result of this procedure. Studies have described an increased risk of perinatal complications including premature and low birth weight infants, although whether these complications occur as a result of the ICSI procedure or secondary to parental infertility remains unknown. Congenital anomalies have also been observed in ICSI-conceived offspring and studies have looked at whether ICSI has an effect on neurodevelopmental outcome. This chapter aims to add to the current understanding of these known outcomes.

Keywords

Intracytoplasmic sperm injections (ICSI)assisted reproductive technology (ART)children outcome
Type
Chapter
Information
Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction
With Other Advanced Micromanipulation Techniques to Edit the Genetic and Cytoplasmic Content of the Oocyte
 , pp. 87 - 94
Publisher: Cambridge University Press
Print publication year: 2021

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References

Pandey, S., Shetty, A., Hamilton, M., Bhattacharya, S. and Maheshwari, A. (2012). Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Human Reproduction Update, 18(5),pp.485–503.CrossRefGoogle ScholarPubMed
Hourvitz, A., Pri-paz, S., Dor, J. and Seidman, D. (2005). Neonatal and obstetric outcome of pregnancies conceived by ICSI or IVF. Reproductive BioMedicine Online, 11(4),pp.469–475.CrossRefGoogle ScholarPubMed
Nouri, K., Ott, J., Stoegbauer, L., Pietrowski, D., Frantal, S. and Walch, K. (2013). Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center – a pilot study. Reproductive Biology and Endocrinology, 11(1),p.84.CrossRefGoogle Scholar
Luke, B. and Keith, L.G. (1992). The contribution of singletons, twins and triplets to low birth weight, infant mortality and handicap in the United States. Journal of Reproductive Medicine, 37,pp.661–666.Google ScholarPubMed
Helmerhorst, F.M., Perquin, D.A., Donker, D. and Keirse, M.J.N.C. (2004). Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. British Medical Journal, 328,pp.261–265.CrossRefGoogle Scholar
Henriksen, T.B., Baird, D.D., Olsen, J., Hedegaard, M., Secher, N.J. and Wilcox, A.J. (1997) Time to pregnancy and preterm delivery. Obstetrics and Gynecology, 89(4),pp.594–599.Google Scholar
Esteves, S. and Agarwal, A. (2013). The azoospermic male: current knowledge and future perspectives. Clinics, 68(S1),pp.1–4.CrossRefGoogle ScholarPubMed
McElrath, T. and Wise, P.H. (1997). Fertility therapy and the risk of very low birth weight. Obstetrics and Gynecology, 90(4),pp.600–605.CrossRefGoogle ScholarPubMed
Hansen, M., Kurinczuk, J., Bower, C. and Webb, S. (2002). The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. New England Journal of Medicine, 346(10),pp.725–730.CrossRefGoogle ScholarPubMed
Wennerholm, U., Bergh, C., Hamberger, L., Lundin, K., Nilsson, L., Wikland, M. and Källén, B. (2000). Incidence of congenital malformations in children born after ICSI. Human Reproduction, 15(4),pp.944–948.CrossRefGoogle ScholarPubMed
Sweet, R.A., Schrott, H.G., Kirland, R., Culp, O.S. (1974). Study of the incidence of hypospadias in Rochester Minnesota 1940–1970 and a case control comparison of possible etiological factors. Mayo Clinic Proceedings, 49,pp.52–58.Google Scholar
Ludwig, A., Katalinic, A., Thyen, U., Sutcliffe, A., Diedrich, K. and Ludwig, M. (2009). Physical health at 5.5 years of age of term-born singletons after intracytoplasmic sperm injection: results of a prospective, controlled, single-blinded study. Fertility and Sterility, 91(1),pp.115–124.CrossRefGoogle ScholarPubMed
Mau Kai, C., Main, K., Andersen, A., Loft, A., Skakkebæk, N. and Juul, A. (2007). Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection. The Journal of Clinical Endocrinology & Metabolism, 92(7),pp.2598–2603.CrossRefGoogle ScholarPubMed
Lie, R., Lyngstadass, A., Ørstavik, K., Bakketeig, L., Jacobsen, G. and Tanbo, T. (2004). Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis. International Journal of Epidemiology, 34(3),pp.696–701.Google Scholar
Giorgione, V., Parazzini, F., Fesslova, V., Cipriani, S., Candiani, M., Inversetti, A., et al. (2018). Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta-analysis. Ultrasound in Obstetrics & Gynecology, 51(1),pp.33–42.CrossRefGoogle ScholarPubMed
Maher, E.R., Brueton, L.A., Bowdin, S.C., Luharia, A., Cooper, W., Cole, T.R., Macdonald, F., Sampson, J.R., Barratt, C.L., Reik, W. and Hawkins, M.M. (2003). Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). Journal of Medical Genetics, 40(1),pp.62–64.Google Scholar
Ørstavik, K., Eiklid, K., van der Hagen, C., Spetalen, S., Kierulf, K., Skjeldal, O. and Buiting, K. (2003). Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic sperm injection. The American Journal of Human Genetics, 72(1),pp.218–219.CrossRefGoogle Scholar
Horsthemke, B. and Ludwig, M. (2005). Assisted reproduction: the epigenetic perspective. Human Reproduction Update, 11,pp.473–482.Google Scholar
Schreurs, A., Legius, E., Meuleman, C., Fryns, J.P. and D’hooghe, T.M. (2000). Increased frequency of chromosomal abnormalities in female partners of couples undergoing in vitro fertilization or intracytoplasmic sperm injection. Fertility & Sterility, 74,pp.94–96.CrossRefGoogle ScholarPubMed
Hansen, M., Bower, C., Milne, E., de Klerk, N. and Kurinczuk, J.J. (2005). Assisted reproductive technologies and the risk of birth defects-a systematic review. Human Reproduction, 20,pp.328–333.CrossRefGoogle ScholarPubMed
Sutcliffe, A., Taylor, B., Saunders, K., Thornton, S., Leiberman, B. and Grudzinskas, J. (2001). Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. The Lancet, 357(9274),pp.2080–2084.CrossRefGoogle ScholarPubMed
Agarwal, P., Loh, S., Lim, S., Sriram, B., Daniel, M., Yeo, S. and Heng, D. (2005). Two-year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study. BJOG: An International Journal of Obstetrics & Gynaecology, 112(10),pp.1376–1383.CrossRefGoogle ScholarPubMed
Ponjaert-Kristoffersen, I., Bonduelle, M., Barnes, J., Nekkebroeck, J., Loft, A., Wennerholm, U.-B., et al.(2005). International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics, 115(3),pp.e283–e289.Google Scholar
Bonduelle, M. Ponjaert, I., Van Steirteghem, A., Derde, M.-P., Devroey, P. and Liebaers, I. (2003). Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF. Human Reproduction, 18(2),pp.342–350.CrossRefGoogle ScholarPubMed
Hashem, M., Mahmoud, N., Aboulghar, H., Omar, A., El Shamaa, M. and Moustafa, R. (2010). Karyotyping and neurodevelopmental follow-up of intracytoplasmic sperm injection children up to 4 years of age. Middle East Fertility Society Journal, 15(1),pp.21–28.CrossRefGoogle Scholar
Place, I. and Englert, Y. (2003). A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertility and Sterility, 80(6),pp.1388–1397.Google Scholar
Pinborg, A., Lidegaard, Ø., la Cour Freiesleben, N. and Andersen, A. (2005). Consequences of vanishing twins in IVF/ICSI pregnancies. Human Reproduction, 20(10),pp.2821–2829.Google Scholar
Catford, S., McLachlan, R., O’Bryan, M. and Halliday, J. (2017). Long-term follow-up of intra-cytoplasmic sperm injection-conceived offspring compared with in vitro fertilization-conceived offspring: a systematic review of health outcomes beyond the neonatal period. Andrology, 5(4),pp.610–621.Google Scholar
Hargreave, M., Jensen, A., Toender, A., Andersen, K. and Kjaer, S. (2013). Fertility treatment and childhood cancer risk: a systematic meta-analysis. Fertility and Sterility, 100(1),pp.150–161.Google Scholar
Lerner-Geva, L., Boyko, V., Ehrlich, S., Mashiach, S., Hourvitz, A., Haas, J., et al. (2016). Possible risk for cancer among children born following assisted reproductive technology in Israel. Pediatric Blood & Cancer, 64(4), p.e26292.CrossRefGoogle ScholarPubMed
Belva, F., Roelants, M., Vloeberghs, V., Schiettecatte, J., Evenepoel, J., Bonduelle, M. and de Vos, M. (2017). Serum reproductive hormone levels and ultrasound findings in female offspring after intracytoplasmic sperm injection: first results. Fertility and Sterility, 107(4),pp.934–939.CrossRefGoogle ScholarPubMed
Belva, F., Roelants, M., De Schepper, J., Van Steirteghem, A., Tournaye, H. and Bonduelle, M. (2016). Reproductive hormones of ICSI-conceived young adult men: the first results. Human Reproduction, 32(2),pp.439–446.CrossRefGoogle ScholarPubMed
Belva, F., Henriet, S., Liebaers, I., Van Steirteghem, A., Celestin-Westreich, S. and Bonduelle, M. (2006). Medical outcome of 8-year-old singleton ICSI children (born >=32 weeks’ gestation) and a spontaneously conceived comparison group. Human Reproduction, 22(2),pp.506–515.CrossRefGoogle Scholar
Leunens, L., Celestin-Westreich, S., Bonduelle, M., Liebaers, I. and Ponjaert-Kristoffersen, I. (2007). Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children. Human Reproduction, 23(1),pp.105–111.Google Scholar
Bonduelle, M., Wennerholm, U., Loft, A., Tarlatzis, B., Peters, C., Henriet, S., et al. (2005). A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Human Reproduction, 20(2),pp.413–419.CrossRefGoogle ScholarPubMed

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