Book contents
- Frontmatter
- Contents
- List of contributors
- Foreword – Alan B. Scott
- Preface
- 1 The pretherapeutic history of botulinum toxin
- 2 Botulinum toxin: history of clinical development
- 3 Pharmacology of botulinum toxin drugs
- 4 Immunological properties of botulinum toxins
- 5 Treatment of cervical dystonia
- 6 Treatment of hemifacial spasm
- 7 Treatment of blepharospasm
- 8 Treatment of oromandibular dystonia
- 9 Treatment of focal hand dystonia
- 10 Botulinum toxin applications in ophthalmology
- 11 Botulinum toxin therapy of laryngeal muscle hyperactivity syndromes
- 12 The use of botulinum toxin in otorhinolaryngology
- 13 Spasticity
- 14 The use of botulinum toxin in spastic infantile cerebral palsy
- 15 Hyperhidrosis
- 16 Cosmetic uses of botulinum toxins
- 17 Botulinum toxin in the gastrointestinal tract
- 18 Botulinum toxin in urological disorders
- 19 Use of botulinum toxin in musculoskeletal pain and arthritis
- 20 The use of botulinum toxin in the management of headache disorders
- 21 Treatment of plantar fasciitis with botulinum toxin
- 22 Treatment of stiff-person syndrome with botulinum toxin
- 23 Botulinum toxin in tic disorders and essential hand and head tremor
- 24 Developing the next generation of botulinum toxin drugs
- Index
- References
14 - The use of botulinum toxin in spastic infantile cerebral palsy
Published online by Cambridge University Press: 28 July 2009
- Frontmatter
- Contents
- List of contributors
- Foreword – Alan B. Scott
- Preface
- 1 The pretherapeutic history of botulinum toxin
- 2 Botulinum toxin: history of clinical development
- 3 Pharmacology of botulinum toxin drugs
- 4 Immunological properties of botulinum toxins
- 5 Treatment of cervical dystonia
- 6 Treatment of hemifacial spasm
- 7 Treatment of blepharospasm
- 8 Treatment of oromandibular dystonia
- 9 Treatment of focal hand dystonia
- 10 Botulinum toxin applications in ophthalmology
- 11 Botulinum toxin therapy of laryngeal muscle hyperactivity syndromes
- 12 The use of botulinum toxin in otorhinolaryngology
- 13 Spasticity
- 14 The use of botulinum toxin in spastic infantile cerebral palsy
- 15 Hyperhidrosis
- 16 Cosmetic uses of botulinum toxins
- 17 Botulinum toxin in the gastrointestinal tract
- 18 Botulinum toxin in urological disorders
- 19 Use of botulinum toxin in musculoskeletal pain and arthritis
- 20 The use of botulinum toxin in the management of headache disorders
- 21 Treatment of plantar fasciitis with botulinum toxin
- 22 Treatment of stiff-person syndrome with botulinum toxin
- 23 Botulinum toxin in tic disorders and essential hand and head tremor
- 24 Developing the next generation of botulinum toxin drugs
- Index
- References
Summary
Introduction
Cerebral palsy is not a specific disease but a group of clinical syndromes, caused by a non-progressive injury to the developing brain that results in a disorder of movement and posture that is permanent but not unchanging. It is the most common cause of physical disability affecting children in developed countries. The incidence is steady in most countries at approximately 2/1000 live births. The location, timing, and severity of the brain lesion are extremely variable, which results in many different clinical presentations. Despite the static nature of the brain injury, the majority of children with cerebral palsy develop progressive musculoskeletal problems such as spastic posturing and muscle contractures (Koman et al., 2004).
Classification
Cerebral palsy may be classified according to the cause of the brain lesion (when this is known), and the location of the brain lesion as noted on imaging such as magnetic resonance imaging or computerized tomography scan. Clinically more useful classification schemes are based on the type of movement disorder, the distribution of the movement disorder (Box 14.1), and the gross motor function of the child.
It is important to correctly characterize the movement disorder because different movement disorders can be managed by different interventions.
- Type
- Chapter
- Information
- Manual of Botulinum Toxin Therapy , pp. 115 - 122Publisher: Cambridge University PressPrint publication year: 2009