Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-24T17:07:26.378Z Has data issue: false hasContentIssue false

1.08 - Approach to Anxiety in Schizophrenia Spectrum Patients

from Part I - Treatment Strategies

Published online by Cambridge University Press:  19 October 2021

Michael Cummings
Affiliation:
University of California, Los Angeles
Stephen Stahl
Affiliation:
University of California, San Diego
Get access

Summary

Large studies and meta-analyses have noted that anxiety symptoms can occur in up to 65% of patients with schizophrenia, and the prevalence of any anxiety disorder (at the syndromal level) is estimated to be up to 38% [1, 2]. Anxiety symptoms are thus commonly encountered when treating patients with chronic psychotic disorders; however, of equal importance is the conclusion that more than 40% of schizophrenia spectrum patients who report an anxiety symptom are suffering from a cause other than a primary anxiety disorder or depression with anxiety. The differential diagnosis of anxiety symptoms is quite broad among patients with chronic psychotic disorders, but the correct action depends greatly on the underlying etiology. Reflexive use of a benzodiazepine or a selective serotonin reuptake inhibitor (SSRI) to treat anxiety is not appropriate in many instances and can be associated with deleterious outcomes such as increased mortality (benzodiazepines), or antidepressant-induced destabilization of patients with a bipolar diathesis (i.e. patients with a diagnosis of schizoaffective disorder, bipolar type). The issues to consider in documenting a treatment rationale are outlined in Table 8.1. A thoughtful review of the anxiety symptom evolution in relationship to medication changes or other factors should enable the clinician to arrive at a testable hypothesis and plot a course of action.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Temmingh, H., Stein, D. J. (2015). Anxiety in patients with schizophrenia: epidemiology and management. CNS Drugs, 29, 819832.CrossRefGoogle ScholarPubMed
Bosanac, P., Mancuso, S. G., Castle, D. J. (2016). Anxiety symptoms in psychotic disorders: results from the Second Australian National Mental Health Survey. Clin Schizophr Relat Psychoses, 10, 93100.CrossRefGoogle ScholarPubMed
Van der Heiden, W., Konnecke, R., Maurer, K., et al. (2005). Depression in the long-term course of schizophrenia. Eur Arch Psychiatry Clin Neurosci, 255, 174184.CrossRefGoogle ScholarPubMed
Wang, D., Gopal, S., Baker, S., et al. (2018). Trajectories and changes in individual items of positive and negative syndrome scale among schizophrenia patients prior to impending relapse. NPJ Schizophr, 4, 10.Google Scholar
Velligan, D., Carpenter, W., Waters, H. C., et al. (2018). Relapse Risk Assessment for Schizophrenia Patients (RASP): a new self-report screening tool. Clin Schizophr Relat Psychoses, 11, 224235.CrossRefGoogle ScholarPubMed
Lohr, J. B., Eidt, C. A., Abdulrazzaq Alfaraj, A., et al. (2015). The clinical challenges of akathisia. CNS Spectr, 20 Suppl. 1, 114; quiz 1516.CrossRefGoogle ScholarPubMed
Porcelli, S., Bianchini, O., De Girolamo, G., et al. (2016). Clinical factors related to schizophrenia relapse. Int J Psychiatry Clin Pract, 20, 5469.CrossRefGoogle ScholarPubMed
Salem, H., Nagpal, C., Pigott, T., et al. (2017). Revisiting antipsychotic-induced akathisia: current issues and prospective challenges. Curr Neuropharmacol, 15, 789798.Google Scholar
Shear, M. K., Frances, A., Weiden, P. (1983). Suicide associated with akathisia and depot fluphenazine treatment. J Clin Psychopharmacol, 3, 235236.CrossRefGoogle ScholarPubMed
Drake, R. E., Ehrlich, J. (1985). Suicide attempts associated with akathisia. Am J Psychiatry, 142, 499501.Google ScholarPubMed
Sachdev, P., Loneragan, C. (1992). Reported association of akathisia with suicide. J Nerv Ment Dis, 180, 339.CrossRefGoogle ScholarPubMed
Lima, A. R., Soares-Weiser, K., Bacaltchuk, J., et al. (2002). Benzodiazepines for neuroleptic-induced acute akathisia. Cochrane Database Syst Rev, 1999(1), CD001950.Google ScholarPubMed
Lima, A. R., Bacalcthuk, J., Barnes, T. R., et al. (2004). Central action beta-blockers versus placebo for neuroleptic-induced acute akathisia. Cochrane Database Syst Rev, 2004, CD001946.Google Scholar
Praharaj, S. K., Kongasseri, S., Behere, R. V., et al. (2015). Mirtazapine for antipsychotic-induced acute akathisia: a systematic review and meta-analysis of randomized placebo-controlled trials. Ther Adv Psychopharmacol, 5, 307313.CrossRefGoogle ScholarPubMed
Lima, A. R., Weiser, K. V., Bacaltchuk, J., et al. (2004). Anticholinergics for neuroleptic-induced acute akathisia. Cochrane Database Syst Rev, 2004, CD003727.Google Scholar
Vinogradov, S., Fisher, M., Warm, H., et al. (2009). The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia. Am J Psychiatry, 166, 10551062.CrossRefGoogle ScholarPubMed
Borghans, L., Sambeth, A., Blokland, A. (2020). Biperiden selectively impairs verbal episodic memory in a dose- and time-dependent manner in healthy subjects. J Clin Psychopharmacol, 40, 3037.CrossRefGoogle Scholar
Tiihonen, J., Suokas, J. T., Suvisaari, J. M., et al. (2012). Polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia. Arch Gen Psychiatry, 69, 476483.CrossRefGoogle ScholarPubMed
Tiihonen, J., Mittendorfer-Rutz, E., Torniainen, M., et al. (2016). Mortality and cumulative exposure to antipsychotics, antidepressants, and benzodiazepines in patients with schizophrenia: an observational follow-up study. Am J Psychiatry, 173, 600606.Google Scholar
Young, S., Pfaff, D., Lewandowski, K. E., et al. (2013). Anxiety disorder comorbidity in bipolar disorder, schizophrenia and schizoaffective disorder. Psychopathology, 46, 176185.CrossRefGoogle ScholarPubMed
Serafini, G., Gonda, X., Aguglia, A., et al. (2019). Bipolar subtypes and their clinical correlates in a sample of 391 bipolar individuals. Psychiatry Res, 281, 112528.CrossRefGoogle Scholar
Leucht, S., Helfer, B., Dold, M., et al. (2015). Lithium for schizophrenia. Cochrane Database Syst Rev, 2015, CD003834.Google Scholar
Dold, M., Li, C., Tardy, M., et al. (2012). Benzodiazepines for schizophrenia. Cochrane Database Syst Rev, 11, CD006391.Google ScholarPubMed
Zaman, H., Sampson, S. J., Beck, A. L., et al. (2017). Benzodiazepines for psychosis-induced aggression or agitation. Cochrane Database Syst Rev, 12, CD003079.Google ScholarPubMed
Dold, M., Li, C., Gillies, D., et al. (2013). Benzodiazepine augmentation of antipsychotic drugs in schizophrenia: a meta-analysis and Cochrane review of randomized controlled trials. Eur Neuropsychopharmacol, 23, 10231033.CrossRefGoogle ScholarPubMed
Murru, A., Pacchiarotti, I., Nivoli, A. M., et al. (2011). What we know and what we don’t know about the treatment of schizoaffective disorder. Eur Neuropsychopharmacol, 21, 680690.CrossRefGoogle ScholarPubMed
Tezenas du Montcel, C., Pelissolo, A., Schurhoff, F., et al. (2019). Obsessive-compulsive symptoms in schizophrenia: an up-to-date review of literature. Curr Psychiatry Rep, 21, 64.CrossRefGoogle ScholarPubMed
Scotti-Muzzi, E., Saide, O. L. (2017). Schizo-obsessive spectrum disorders: an update. CNS Spectr, 22, 258272.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×