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Chapter 13 - Artificial Insemination with Partner’s Sperm for Male Subfertility

Published online by Cambridge University Press:  24 May 2020

By
Willem Ombelet
Edited by
R. John Aitken ,
David Mortimer  and
Gabor Kovacs
R. John Aitken
Affiliation:
University of Newcastle, New South Wales
David Mortimer
Affiliation:
Oozoa Biomedical Inc, Vancouver
Gabor Kovacs
Affiliation:
Epworth Healthcare Melbourne
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Summary

According to a number of high-quality studies, intrauterine insemination (IUI) with homologous semen should be the first choice of treatment in the case of moderate male factor subfertility. IVF and ICSI are clearly over-used in this selected group of infertile couples. The limited value of IUI in infertility treatment, as mentioned in the 2013 NICE guidelines, was surely a premature statement and should be adapted to the actual literature. Oxidative stress and high sperm DNA damage is associated with lower pregnancy rates after IUI. Concerning clinical outcome, there is no clear evidence of any sperm preparation technique to be superior. More evidence-based data are becoming available on different variables influencing the success rates after IUI. It can be expected that these findings may lead to a better understanding and use of IUI in the near future.

Keywords

artificial inseminationassisted reproductionintrauterine inseminationIUImale subfertilityNICE guidelinessemen qualityunexplained infertility
Type
Chapter
Information
Male and Sperm Factors that Maximize IVF Success , pp. 154 - 165
Publisher: Cambridge University Press
Print publication year: 2020

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