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15 - T-cell lymphoma

from Part II - LYMPHOMA SUBTYPES

Published online by Cambridge University Press:  05 March 2010

By
Mujahid A. Rizvi ,
Andrew M. Evens ,
Beverly P. Nelson ,
Steven T. Rosen ,
Andrew Wotherspoon ,
Andreas Rosenwald  and
German Ott
Edited by
Robert Marcus ,
John W. Sweetenham  and
Michael E. Williams
Mujahid A. Rizvi
Affiliation:
Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago IL, 60611, USA
Andrew M. Evens
Affiliation:
Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA
Beverly P. Nelson
Affiliation:
Section of Hematopathology, Department of Pathology, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA
Steven T. Rosen
Affiliation:
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA
Andrew Wotherspoon
Affiliation:
Department of Histopathology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK
Andreas Rosenwald
Affiliation:
Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany
German Ott
Affiliation:
Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany
Robert Marcus
Affiliation:
Addenbrooke's NHS Foundation Trust, Cambridge
John W. Sweetenham
Affiliation:
Case Western Reserve University, Ohio
Michael E. Williams
Affiliation:
University of Virginia
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Summary

INTRODUCTION

T-cell non-Hodgkin's lymphomas (NHL) are uncommon malignancies, representing approximately 12% of all lymphomas. Various geographic frequencies of T-cell NHL have been documented, ranging from 18.3% of NHL diagnosed in Hong Kong to 1.5% in Vancouver, Canada. This may in part reflect increased exposure to pathogenic factors such as human T-cell leukemia virus 1 (HTLV-1) and Epstein–Barr virus (EBV) in Asian nations. T-cell NHL commonly presents with extranodal disease and often contains varying amounts of necrosis/apoptosis on biopsy specimens, making differentiation between a reactive process and lymphoma challenging. Immunophenotypic, cytogenetic and molecular analyses have enhanced diagnostic capabilities as well as improved classification and prognostication for T-cell NHL.

The current World Health Organization/European Organisation for Research and Treatment of Cancer (WHO/EORTC) classification recognizes nine distinct clinicopathologic peripheral T-cell NHLs. The broad spectrum of pathologic subtypes with varied clinical behavior poses a challenge to the systematic study of these diseases. Furthermore, these distinct T-cell NHL subtypes have unique characteristics and often warrant individualized diagnostic and therapeutic treatment strategies. The primary cutaneous T-cell lymphomas are reviewed in Chapter 16. Here we review the etiology, pathology, diagnosis and treatment strategies for patients with peripheral T-cell lymphomas (Table 15.1).

ETIOLOGY

Genetic alterations involved in lymphoma oncogenesis include chromosome rearrangements, disruption of tumor suppressor genes and an increase in the number of copies of genes (gene amplification). Moreover, infection of cells by viruses and bacteria such as HTLV-I, human herpesvirus 8 (HHV-8), hepatitis C and Helicobacter pylori may also contribute to lymphomagenesis.

Type
Chapter
Information
Lymphoma: Pathology, Diagnosis and Treatment , pp. 215 - 232
Publisher: Cambridge University Press
Print publication year: 2007

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References

A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood 89 (1997), 3909–3918.
Ansell, S. M., Habermann, T. M., Kurtin, P. J.et al. Predictive capacity of the International Prognostic Factor Index in patients with peripheral T-cell lymphoma. J. Clin. Oncol. 15 (1997), 2296–2301.CrossRefGoogle ScholarPubMed
Attygalle, A., Al-Jehani, R., Diss, T. C.et al. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 99 (2002), 627–633.CrossRefGoogle ScholarPubMed
Belhadj, K., Reyes, F., Farcet, J. P.et al. Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood 102 (2003), 4261–4269.CrossRefGoogle ScholarPubMed
Benharroch, D., Meguerian-bedoyan, Z., Lamant, L.et al. ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91 (1998), 2076–2084.Google ScholarPubMed
Drexler, H. G., MacLeod, R. A., Borkhardt, A. and Janssen, J. W.Recurrent chromosomal translocations and fusion genes in leukemia–lymphoma cell lines. Leukemia 9 (1995), 480–500.Google ScholarPubMed
Falini, B., Pileri, S., Zinzani, P. L.et al. ALK + lymphoma: clinico-pathological findings and outcome. Blood 93 (1999), 2697–2706.Google ScholarPubMed
Gallamini, A., Stelitano, C., Calvi, R.et al. Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study. Blood 103 (2004), 2474–2479.CrossRefGoogle ScholarPubMed
Gascoyne, R. D., Aoun, P., Wu, D.et al. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood 93 (1999), 3913–3921.Google ScholarPubMed
Gisselbrecht, C., Gaulard, P., Lepage, E.et al. Prognostic significance of T-cell phenotype in aggressive non-Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA). Blood 92 (1998), 76–82.Google Scholar
Harris, N. L., Jaffe, E. S., Diebold, J.et al. The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997. Ann. Oncol. 10 (1999), 1419–1432.CrossRefGoogle Scholar
Kanavaros, P., Lescs, M. C., Briere, J.et al. Nasal T-cell lymphoma: a clinicopathologic entity associated with peculiar phenotype and with Epstein–Barr virus. Blood 81 (1993), 2688–2695.Google ScholarPubMed
McArthur, H. L., Chhanabhai, M., Randy, G. D.et al. Evaluation of a New Prognostic Index for peripheral T-Cell lymphoma, unspecified (PTCL-US). Blood 106 (2005), 2812a.Google Scholar
Matutes, E., Brito-Babapulle, V., Swansbury, J.et al. Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia. Blood 78 (1991), 3269–3274.Google ScholarPubMed
Melnyk, A., Rodriguez, A., Pugh, W. C. and Cabannillas, F.Evaluation of the Revised European–American Lymphoma classification confirms the clinical relevance of immunophenotype in 560 cases of aggressive non-Hodgkin's lymphoma. Blood 89 (1997), 4514–4520.Google ScholarPubMed
Morice, W. G., Kurtin, P. J., Tefferi, A. and Hanson, C. A.Distinct bone marrow findings in T-cell granular lymphocyte leukaemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1 and granzyme B. Blood 99 (2002), 268–274.CrossRefGoogle ScholarPubMed
Osuji, N., Matutes, E., Catovsky, D., Lampert, I. A. and Wotherspoon, A. Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review. Am. J. Surg. Pathol. 29 (2005), 935–941.CrossRefGoogle ScholarPubMed
Pellatt, J., Sweetenham, J., Pickering, R. M., Brown, L. and Wilkins, B.A single-centre study of treatment outcomes and survival in 120 patients with peripheral T-cell non-Hodgkin's lymphoma. Ann. Hematol. 81 (2002), 267–272.Google ScholarPubMed
Rizvi, M. A., Evens, A. M., Tallman, M. S., Nelson, B. P. and Rosen, S. T.T-cell non-Hodgkin's lymphoma. Blood 107 (2006), 1255–1264.CrossRefGoogle Scholar
Rudiger, T., Weisenburger, D. D., Anderson, J. R.et al. Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project. Ann. Oncol. 13 (2002), 140–149.CrossRefGoogle ScholarPubMed
Salhany, K. E., Macon, W. R., Choi, J. K.et al. Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am. J. Surg. Pathol. 22 (1998), 881–893.CrossRefGoogle ScholarPubMed
Savage, K. J., Chhanabhai, M., Voss, N.et al. Survival of limited stage peripheral T-cell lymphoma is similar to diffuse large B-cell lymphoma. Blood 106 (2005), 2817a.Google Scholar

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  • T-cell lymphoma
    • By Mujahid A. Rizvi, Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago IL, 60611, USA, Andrew M. Evens, Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Beverly P. Nelson, Section of Hematopathology, Department of Pathology, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Steven T. Rosen, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Andrew Wotherspoon, Department of Histopathology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK, Andreas Rosenwald, Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany, German Ott, Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany
  • Edited by Robert Marcus, John W. Sweetenham, Case Western Reserve University, Ohio, Michael E. Williams, University of Virginia
  • Book: Lymphoma: Pathology, Diagnosis and Treatment
  • Online publication: 05 March 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511663369.016
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  • T-cell lymphoma
    • By Mujahid A. Rizvi, Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago IL, 60611, USA, Andrew M. Evens, Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Beverly P. Nelson, Section of Hematopathology, Department of Pathology, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Steven T. Rosen, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Andrew Wotherspoon, Department of Histopathology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK, Andreas Rosenwald, Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany, German Ott, Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany
  • Edited by Robert Marcus, John W. Sweetenham, Case Western Reserve University, Ohio, Michael E. Williams, University of Virginia
  • Book: Lymphoma: Pathology, Diagnosis and Treatment
  • Online publication: 05 March 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511663369.016
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • T-cell lymphoma
    • By Mujahid A. Rizvi, Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago IL, 60611, USA, Andrew M. Evens, Division of Hematology/Oncology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Beverly P. Nelson, Section of Hematopathology, Department of Pathology, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Steven T. Rosen, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, 303, E Superior Street, Chicago, IL, 60611, USA, Andrew Wotherspoon, Department of Histopathology, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK, Andreas Rosenwald, Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany, German Ott, Institute of Pathology, University of Würzburg, Josef-Schneider-Str, 2, Würzburg, 97080, Germany
  • Edited by Robert Marcus, John W. Sweetenham, Case Western Reserve University, Ohio, Michael E. Williams, University of Virginia
  • Book: Lymphoma: Pathology, Diagnosis and Treatment
  • Online publication: 05 March 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511663369.016
Available formats
×