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Chapter 22 - Drug-Induced Liver Disease in Children

from Section III - Hepatitis and Immune Disorders

Published online by Cambridge University Press:  19 January 2021

By
Eve A. Roberts
Edited by
Frederick J. Suchy ,
Ronald J. Sokol  and
William F. Balistreri
Edited in association with
Jorge A. Bezerra ,
Cara L. Mack  and
Benjamin L. Shneider
Frederick J. Suchy
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Ronald J. Sokol
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
William F. Balistreri
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Jorge A. Bezerra
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Cara L. Mack
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Benjamin L. Shneider
Affiliation:
Texas Children’s Hospital, Houston
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Summary

Drug-induced liver disease has been regarded as rare in children. Large surveys have generally failed to detect drug hepatotoxicity as a major problem in children [1], although adverse drug reactions (not necessarily hepatotoxic) are somewhat more frequent in preschool children and in children of any age with cancer. A study examining deaths from adverse drug reactions in children found that approximately one-sixth of such deaths involved acute liver failure, usually associated with antiepileptic or anti-neoplastic drugs [2].

Type
Chapter
Information
Liver Disease in Children , pp. 348 - 382
Publisher: Cambridge University Press
Print publication year: 2021

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