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Chapter 9 - Case Studies of Adaptive Trial Designs

from Part IV - Case Studies of Adaptive Trial Designs and Master Protocols

Published online by Cambridge University Press:  20 March 2023

Jay J. H. Park ,
Edward J. Mills  and
J. Kyle Wathen
By
Jay J. H. Park ,
Edward J. Mills  and
J. Kyle Wathen
Jay J. H. Park
Affiliation:
McMaster University, Ontario
Edward J. Mills
Affiliation:
McMaster University, Ontario
J. Kyle Wathen
Affiliation:
Cytel, Cambridge, Massachusetts
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Summary

In this chapter, we review six case studies of adaptive clinical trials. This chapter is intended to complement the previous chapters. We have organised the case studies by their main adaptive design feature. Each case study describes the background of individual trial and summarises key design details and overall results. Our presentation and discussion do not necessarily represent the official view of the trial investigators. Our discussion is intended to improve the reader’s general literacy and comprehension of published results of adaptive clinical trials.

Keywords

adaptive trial designsgroup sequential designsseamless designsample size re-assessmentresponse adaptive randomisationenrichment design
Type
Chapter
Information
Introduction to Adaptive Trial Designs and Master Protocols , pp. 101 - 114
Publisher: Cambridge University Press
Print publication year: 2023

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