Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-03T00:25:25.523Z Has data issue: false hasContentIssue false

Chapter 4 - Structural Connectivity of the Insula

from Section 1 - The Human Insula from an Epileptological Standpoint

Published online by Cambridge University Press:  09 June 2022

Dang Nguyen
Affiliation:
Université de Montréal
Jean Isnard
Affiliation:
Claude Bernard University Lyon
Philippe Kahane
Affiliation:
Grenoble-Alpes University Hospital
Get access

Summary

The insular cortex is an extensively connected brain region that has recently gained considerable interest due to its elusive role in several pathological conditions and its involvement in a variety of functions. Structural connectivity studies have identified connections to the frontal, temporal, and parietal cortices, with both a rostro-caudal and a dorso-ventral organizational pattern. The insula is also widely connected to subcortical structures. The use of diffusion-weighted imaging in insular epilepsy has not yet reached its full potential; however, it may still provide some insights into its pathophysiology, assess long-term consequences, and help prevent operative complications. This chapter explores the insula’s structural connectivity and promising applications in the field of insular epilepsy.

Type
Chapter
Information
Insular Epilepsies , pp. 31 - 39
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Stephani, C., Fernandez-Baca Vaca, G., Maciunas, R., Koubeissi, M., and Luders, H. O., “Functional neuroanatomy of the insular lobe,” Brain Struct Funct, vol. 216, no. 2, pp. 137149, Jun 2011.Google Scholar
Ture, U., Yasargil, D. C., Al-Mefty, O., and Yasargil, M. G., “Topographic anatomy of the insular region,” J Neurosurg, vol. 90, no. 4, pp. 720733, Apr 1999.Google Scholar
Morel, A., Gallay, M. N., Baechler, A., Wyss, M., and Gallay, D. S., “The human insula: Architectonic organization and postmortem MRI registration,” Neuroscience, vol. 236, pp. 117135, Apr 2013.CrossRefGoogle ScholarPubMed
Kurth, F., Zilles, K., Fox, P. T., Laird, A. R., and Eickhoff, S. B., “A link between the systems: Functional differentiation and integration within the human insula revealed by meta-analysis,” Brain Struct Funct, vol. 214, no. 5–6, pp. 519534, Jun 2010.Google Scholar
Namkung, H., Kim, S. H., and Sawa, A., “The insula: An underestimated brain area in clinical neuroscience, psychiatry, and neurology,” Trends Neurosci, vol. 40, no. 4, pp. 200207, Apr 2017.CrossRefGoogle ScholarPubMed
Mesulam, M. M. and Mufson, E. J., “Insula of the old world monkey. III: Efferent cortical output and comments on function,” J Comp Neurol, vol. 212, no. 1, pp. 3852, Nov 1982.CrossRefGoogle ScholarPubMed
Mufson, E. J. and Mesulam, M. M., “Insula of the old world monkey. II: Afferent cortical input and comments on the claustrum,” J Comp Neurol, vol. 212, no. 1, pp. 2337, Nov 1982.CrossRefGoogle ScholarPubMed
Le Bihan, D. and Iima, M., “Diffusion magnetic resonance imaging: What water tells us about biological tissues,” PLoS Biol, vol. 13, no. 7, p. e1002203, Jul 2015.CrossRefGoogle ScholarPubMed
Tournier, J. D., “Diffusion MRI in the brain: Theory and concepts,” Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 112–113, pp. 116, 2019.Google Scholar
Roger, E. et al., “The link between structural connectivity and neurocognition illustrated by focal epilepsy,” Epileptic Disord, vol. 20, no. 2, pp. 8898, Apr 2018.Google Scholar
Jeurissen, B., Descoteaux, M., Mori, S., and Leemans, A., “Diffusion MRI fiber tractography of the brain,” NMR Biomed, vol. 32, no. 4, p. e3785, Apr 2019.CrossRefGoogle ScholarPubMed
Cloutman, L. L., Binney, R. J., Drakesmith, M., Parker, G. J., and Lambon Ralph, M. A., “The variation of function across the human insula mirrors its patterns of structural connectivity: evidence from in vivo probabilistic tractography,” Neuroimage, vol. 59, no. 4, pp. 35143521, Feb 2012.Google Scholar
Cauda, F., D’Agata, F., Sacco, K., Duca, S., Geminiani, G., and Vercelli, A., “Functional connectivity of the insula in the resting brain,” Neuroimage, vol. 55, no. 1, pp. 823, Mar 2011.Google Scholar
Cerliani, L. et al., “Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex,” Hum Brain Map, vol. 33, no. 9, pp. 20052034, Sep 2012.Google Scholar
Jakab, A., Molnar, P. P., Bogner, P., Beres, M., and Berenyi, E. L., “Connectivity-based parcellation reveals interhemispheric differences in the insula,” Brain Topogr, vol. 25, no. 3, pp. 264271, Jul 2012.Google Scholar
Nomi, J. S., Schettini, E., Broce, I., Dick, A. S., and Uddin, L. Q., “Structural connections of functionally defined human insular subdivisions,” Cereb Cortex, vol. 28, no. 10, pp. 34453456, Oct 2018.CrossRefGoogle ScholarPubMed
Deen, B., Pitskel, N. B., and Pelphrey, K. A., “Three systems of insular functional connectivity identified with cluster analysis,” Cereb Cortex, vol. 21, no. 7, pp. 14981506, Jul 2011.CrossRefGoogle ScholarPubMed
Ghaziri, J. et al., “The corticocortical structural connectivity of the human insula,” Cereb Cortex, vol. 27, no. 2, pp. 12161228, Dec 2017.CrossRefGoogle ScholarPubMed
Chang, L. J., Yarkoni, T., Khaw, M. W., and Sanfey, A. G., “Decoding the role of the insula in human cognition: Functional parcellation and large-scale reverse inference,” Cereb Cortex, vol. 23, no. 3, pp. 739749, Mar 2013.CrossRefGoogle ScholarPubMed
Ghaziri, J. et al., “Subcortical structural connectivity of insular subregions,” Sci Rep, vol. 8, no. 1, p. 8596, Jun 2018.Google Scholar
Kelly, C. et al., “A convergent functional architecture of the insula emerges across imaging modalities,” Neuroimage, vol. 61, no. 4, pp. 11291142, Jul 2012.Google Scholar
Glasser, M. F. et al., “A multi-modal parcellation of human cerebral cortex,” Nature, vol. 536, no. 7615, pp. 171178, Aug 2016.CrossRefGoogle ScholarPubMed
DeSalvo, M. N., Douw, L., Tanaka, N., Reinsberger, C., and Stufflebeam, S. M., “Altered structural connectome in temporal lobe epilepsy,” Radiology, vol. 270, no. 3, pp. 842848, Mar 2014.Google Scholar
Nguyen, D. et al., “Diffusion tensor imaging analysis with tract-based spatial statistics of the white matter abnormalities after epilepsy surgery,” Epilepsy Res, vol. 94, no. 3, pp. 189197, May 2011.CrossRefGoogle ScholarPubMed
Yogarajah, M. and Duncan, J. S., “Diffusion-based magnetic resonance imaging and tractography in epilepsy,” Epilepsia, vol. 49, no. 2, pp. 189200, Feb 2008.Google Scholar
Taylor, P. N., Kaiser, M., and Dauwels, J., “Structural connectivity based whole brain modelling in epilepsy,” J Neurosci Methods, vol. 236, pp. 5157, Oct 2014.CrossRefGoogle ScholarPubMed
Gross, R. E., Willie, J. T., and Drane, D. L., “The role of stereotactic laser amygdalohippocampotomy in mesial temporal lobe epilepsy,” Neurosurg Clin N Am, vol. 27, no. 1, pp. 3750, Jan 2016.CrossRefGoogle ScholarPubMed
Anastasopoulos, C. et al., “Local and global fiber tractography in patients with epilepsy,” AJNR Am J Neuroradiol, vol. 35, no. 2, pp. 291296, Feb 2014.Google Scholar
Piper, R. J., Yoong, M. M., Kandasamy, J., and Chin, R. F., “Application of diffusion tensor imaging and tractography of the optic radiation in anterior temporal lobe resection for epilepsy: A systematic review,” Clin Neurol Neurosurg, vol. 124, pp. 5965, Sep 2014.Google Scholar
Bernhardt, B. C., Hong, S., Bernasconi, A., and Bernasconi, N., “Imaging structural and functional brain networks in temporal lobe epilepsy,” Front Hum Neurosci, vol. 7, p. 624, Oct 2013.CrossRefGoogle ScholarPubMed
Bonilha, L. et al., “Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures,” J Neurol Neurosurg Psychiatry, vol. 83, no. 9, pp. 903909, Sep 2012.Google Scholar
Hoeft, F. et al., “More is not always better: Increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome,” J Neurosci, vol. 27, no. 44, pp. 1196011965, Oct 2007.CrossRefGoogle Scholar
Lantz, G., Seeck, M., and Lazeyras, F., “Extent of preoperative abnormalities and focus lateralization predict postoperative normalization of contralateral 1 H-magnetic resonance spectroscopy metabolite levels in patients with temporal lobe epilepsy,” AJNR Am J Neuroradiol, vol. 27, no. 8, pp. 17661769, Sep 2006.Google Scholar
Maier-Hein, K. H. et al., “The challenge of mapping the human connectome based on diffusion tractography,” Nat Commun, vol. 8, no. 1, p. 1349, Nov 2017.Google Scholar
Schilling, K. G. et al., “Limits to anatomical accuracy of diffusion tractography using modern approaches,” Neuroimage, vol. 185, pp. 111, Jan 2019.Google Scholar
Dell’Acqua, F. and Catani, M., “Structural human brain networks: Hot topics in diffusion tractography,” Curr Opin Neurol, vol. 25, no. 4, pp. 375383, Aug 2012.Google Scholar
Thiebaut, M. de Schotten et al., “Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractography,” Neuroimage, vol. 54, no. 1, pp. 4959, Jan 2011.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×