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Chapter 5 - Functional Connectivity of the Insula

from Section 1 - The Human Insula from an Epileptological Standpoint

Published online by Cambridge University Press:  09 June 2022

By
Leila Ayoubian ,
Jean-Didier Lemaréchal  and
Olivier David
Edited by
Dang Nguyen ,
Jean Isnard  and
Philippe Kahane
Dang Nguyen
Affiliation:
Université de Montréal
Jean Isnard
Affiliation:
Claude Bernard University Lyon
Philippe Kahane
Affiliation:
Grenoble-Alpes University Hospital
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Summary

This chapter is about the use of direct electrical stimulation with short current pulses to estimate from recorded SEEG responses the functional connectivity of the insula. First, we review some studies of the literature which reported both intra-insular and extra-insular connectivity, using the anterior-posterior gyral decomposition of the insula. Second, we present the mapping of the responses to insula stimulation from 301 patients explored in SEEG from the database of the F-TRACT project. We show that the SEEG responses are highly spatially resolved on the whole brain, as demonstrated when comparing the stimulations between the anterior and posterior parts of the insula at different spatial resolution of the Lausanne parcellation scheme. In general, the responses to electrical stimulation of the insula are particularly numerous, in comparison to the stimulation of other areas, which suggests that insula is a structure densely connected to the rest of the cortex.

Keywords

tractographyfunctional connectivityinsulaepilepsysingle-pulse electrical stimulation
Type
Chapter
Information
Insular Epilepsies , pp. 40 - 51
Publisher: Cambridge University Press
Print publication year: 2022

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