Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-19T14:49:37.874Z Has data issue: false hasContentIssue false

Chapter 5 - Individualized Management of Male Infertility

Published online by Cambridge University Press:  12 February 2021

Human M. Fatemi
Affiliation:
IVI Middle East Fertility Clinic, Abu Dhabi, UAE
Barbara Lawrenz
Affiliation:
IVI Middle East Fertility Clinic, Abu Dhabi, UAE
Get access

Summary

Approximately 8–15 percent of couples are unable to conceive after 1 year of unprotected intercourse, and they are thereby considered infertile; this problem has become a global health concern, affecting roughly 187 million couples worldwide (). Male factor infertility occurs in 40–50 percent of the infertile couples, being solely responsible in approximately 20 percent of cases and in association with a female factor in another 20–30 percent. Although the male factor infertility is traditionally defined by the presence of abnormal semen parameters, it can nowadays be considered even when the seminal analysis is normal but with abnormal functional sperm tests ().

Type
Chapter
Information
Individualized In-Vitro Fertilization
Delivering Precision Fertility Treatment
, pp. 50 - 64
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Agarwal, A, Majzoub, A, Parekh, N, et al. A schematic overview of the current status of male infertility practice. World J Mens Health 2019;37. doi:10.5534/wjmh.190068.Google Scholar
Diagnostic evaluation of the infertile male: a committee opinion. Fertil Steril 2015;103(3):e1825.CrossRefGoogle Scholar
Virtanen, HE, Jørgensen, N, Toppari, J. Semen quality in the 21st century. Nat Rev Urol 2017;14(2):120130.CrossRefGoogle Scholar
Esteves, SC, Agarwal, A. Novel concepts in male infertility. Int Braz J Urol 2011;37(1):515.CrossRefGoogle ScholarPubMed
Dabaja, AA, Schlegel, PN. Medical treatment of male infertility. Transl Androl Urol 2014;3(1):8.Google Scholar
Neto, FTL, Bach, PV, Najari, BB, et al. Spermatogenesis in humans and its affecting factors. Semin Cell Dev Biol 2016;59:1026.CrossRefGoogle ScholarPubMed
Agarwal, A, Cho, C-L, Majzoub, A, et al. The Society for Translational Medicine: clinical practice guidelines for sperm DNA fragmentation testing in male infertility. Transl Androl Urol 2017;6(S4):S720733.CrossRefGoogle Scholar
Jungwirth, A, Giwercman, A, Tournaye, H, et al. European Association of Urology Guidelines on Male Infertility: the 2012 update. Eur Urol 2012;62(2):324332.CrossRefGoogle Scholar
Kruger, TF, Acosta, AA, Simmons, KF, et al. Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril 1988;49(1):112117.CrossRefGoogle ScholarPubMed
Esteves, SC, Zini, A, Aziz, N, et al. Critical appraisal of World Health Organization’s new reference values for human semen characteristics and effect on diagnosis and treatment of subfertile men. Urology 2012;79(1):1622.Google Scholar
Agarwal, A, Majzoub, A, Parekh, N, et al. A schematic overview of the current status of male infertility practice. World J Mens Health 2019;37. doi:10.5534/wjmh.190068.Google Scholar
Management of nonobstructive azoospermia: a committee opinion. Fertil Steril 2018;110(7):12391245.Google Scholar
Hwang, K, Smith, JF, Coward, RM, et al. Evaluation of the azoospermic male: a committee opinion. Fertil Steril 2018;109(5):777782.CrossRefGoogle Scholar
Esteves, SC. Novel concepts in male factor infertility: clinical and laboratory perspectives. J Assist Reprod Genet 2016;33(10):13191335.CrossRefGoogle ScholarPubMed
Smits, RM, Mackenzie-Proctor, R, Yazdani, A, et al. Antioxidants for male subfertility. Cochrane Database Syst Rev 2019;3:CD007411. doi:10.1002/14651858.CD007411.pub4.Google Scholar
Jensen, CFS, Østergren, P, Dupree, JM, et al. Varicocele and male infertility. Nat Rev Urol 2017;14(9):523533.Google Scholar
Esteves, SC, Agarwal, A. Afterword to varicocele and male infertility: current concepts and future perspectives. Asian J Androl 2016;18(2):319322. doi:10.4103/1008-682X.172820.Google Scholar
Report on varicocele and infertility: a committee opinion. Fertil Steril 2014;102(6):15561560.Google Scholar
Miyaoka, R, Esteves, SC. A critical appraisal on the role of varicocele in male infertility. Adv Urol 2012;2012:19.Google Scholar
Agarwal, A, Hamada, A, Esteves, SC. Insight into oxidative stress in varicocele-associated male infertility: part 1. Nat Rev Urol 2012;9(12):678690.Google Scholar
Esteves, S. Clinical management of infertile men with nonobstructive azoospermia. Asian J Androl 2015;17(3):459470.Google Scholar
The management of obstructive azoospermia: a committee opinion. Fertil Steril 2019;111(5):873880.Google Scholar
Esteves, SC. Interventions to prevent sperm DNA damage effects on reproduction. Adv Exp Med Biol 2019;1166:119148. doi:10.1007/978-3-030-21664-1_8.Google Scholar
Esteves, SC, Santi, D, Simoni, M. An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men. Andrology 2019;6:andr.12724.Google Scholar
Roque, M, Esteves, SC. Effect of varicocele repair on sperm DNA fragmentation: a review. Int Urol Nephrol 2018;50(4):583603.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×