Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-25T21:10:33.576Z Has data issue: false hasContentIssue false

Chapter 17 - Perioperative Medical Management of Older People

Lessons from Hip Fracture Patients

Published online by Cambridge University Press:  04 April 2024

George Tadros
Affiliation:
Aston University, Birmingham
George Crowther
Affiliation:
Leeds and York Partnership NHS Foundation Trust, Leeds
Get access

Summary

The population of the world is ageing. This has led to an increase in interventions and surgical procedures that would have been unheard of about fifty years ago. In this chapter we discuss the perioperative management of older patients, and the emphasis is on hip fracture patients. Factors such as limited physiological reserve, comorbidities, and the trauma of surgery itself are discussed, together with their perioperative management. The impact of pre-existing dementia and of post-operative delirium and depression is also covered here. The pre-operative management of fluid and electrolyte imbalance, the reversal of anticoagulation before surgery, and the treatment of infections are included. The evidence base around cut-offs for haemoglobin levels acceptable for surgery is also discussed. Finally, the post-operative management of acute kidney injury, infections, myocardial infarction, congestive cardiac failure, post-operative delirium, post-operative cognitive dysfunction, and depression is explored in conjunction with their evidence base.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

United Nations. World Population Prospects: The 2017 Revision. New York: United Nations, Department of Economic and Social Affairs, Population Division, 2017.Google Scholar
Kyriacou, H., and Khan, W.S. Important perioperative factors, guidelines and outcomes in the management of hip fractures. Journal of Preoperative Practice 2021, 3(4): 140–6.Google Scholar
National Clinical Guidance Centre. The Management of Hip Fractures in Adults. London: National Clinical Guidance Centre, 2011. www.ncgc.ac.uk.Google Scholar
Carpintero, P., Caeiro, J.R., Carpintero, R., Morales, A., Silva, S., and Mesa, M. Complications of hip fractures: A review. World Journal of Orthopaedics 2014, 5(4): 402–11.Google Scholar
Smith, T., Pelpola, K., Ball, M., Ong, A., and Myint, P.K. Preoperative indicators for mortality following hip fracture surgery: A systematic review and meta-analysis. Age and Ageing 2014, 43(4): 464–71.CrossRefGoogle ScholarPubMed
Cristandi, P., Lenze, E.J., Avidan, M.S., and Rawson, K.S. Trajectories of depressive symptoms after hip fracture. Psychological Medicine 2016, 46(7): 1413–25.Google Scholar
Klestil, T., Roder, C., Stotter, C., Winkler, B., Nehrer, S., Lutz, M., Klerings, I., Wagner, G., Gartlehner, G., and Nussbamer-Streit, B. Impact of timing of surgery in elderly hip fracture patients: A systematic review and meta-analysis. Scientific Reports 2018, 8(1): 13933.CrossRefGoogle ScholarPubMed
HIP ATTACK Investigators. Accelerated surgery versus standard care in hip fracture (HIP ATTACK): An international, randomised, controlled trial. Lancet 2020, 395(10225): 698708. doi: 10.1016/S0140-6736(20)30058-1.CrossRefGoogle Scholar
Gringoryan, K.V., Javendan, H., and Rudolph, J.L. Orthogeriatric care models and outcomes in hip fracture patients: A systematic review and meta-analysis. Dtsch Arztebi Int 2013, 110: 255–62.Google Scholar
Alvis, B.O., and Hughes, C.G. Physiology considerations in geriatric patients. Anesthesia / Clin. 2015, 33(3): 447–56. doi: 10.1016/j.anclin.2015.05.003.Google ScholarPubMed
Coccia, F., and Rozzini, R. Goals of surgery and assessment tools for the elderly patients referred for cardiac and non-cardiac surgery. Monaldi Archives for Chest Disease 2017, 87: 849.CrossRefGoogle Scholar
Leung, F., Lau, T.W., Kwan, K., Chow, S.P., and Kung, A.W. Does timing of surgery matter in fragility hip fractures? Osteoporosis International 2010, 21(4): s529s534.CrossRefGoogle ScholarPubMed
Sobolev, B., Guy, P., Sheehan, K.J., Kuramoto, L., Sutherland, J.M. et al. Mortality effects of timing alternatives for hip fracture surgery. Canadian Medical Association Journal 2018, 190(3): E923–32.CrossRefGoogle ScholarPubMed
Lee, D.J., and Elfar, J.C. Timing of hip fracture surgery in the elderly. Geriatric Orthopaedic Surgery and Rehabilitation 2014, 5(3): 138–40.CrossRefGoogle ScholarPubMed
Bennet, A., Hsin, L., Patel, A., Kang, K., Gupta, P., Choueka, J., and Feierman, D.E. Retrospective analysis of Geriatric patients undergoing hip fracture surgery: Delaying surgery is associated with increased morbidity, mortality and length of stay. Geriatric Orthopaedic Surgery and Rehabilitation 2018, 9. 2151459318795260.Google Scholar
Association of Anaesthetists of Great Britain and Ireland. Management of proximal femoral fractures. Anaesthesia 2012, 67: 8598.Google Scholar
Sheehan, K.J., Sobolev, B., Villan, Y.F.V., and Guy, P. Patients and system factors of time to surgery after hip fracture: A scoping review. BMJ Open 2017, 7: e016939. doi: 10.1136/bmjopen-2017-016939.CrossRefGoogle ScholarPubMed
Zehir, R., Zehir, S., and Kocabay, G. Role of pre-operative electro cardiology in predicting cardiovascular complications in proximal femur su rgery. Current Research Cardiology 2015, 2(4): 171–4.CrossRefGoogle Scholar
Bryant, H.C., Roberts, P.R., and Diprose, P. Perioperative management of patients with cardiac implantable electric devices. British Journal of Anaesthesia Education 2016, 16(11): 357–61.Google Scholar
Royal College of Physicians. National Hip Fracture Database Annual Report, 2017. London: RCP, 2017.Google Scholar
Mochinski, K., Kurke, S., Andrich, S., Astrid, S., Gnass, I., Sirch, E., and lcks, A. Drug-based pain management for people with dementia after hip or pelvic fract ures: A systematic review. BMC Geriatrics 2017, 17(1): 54. doi: 10.1186/s12877-017-0446-2.CrossRefGoogle Scholar
Sampson, E., White, N., Lord, K., Leurent, B., Vickerstaff, V., Scott, S., and Jones, L. Pain, agitation, and behavioural problems in people with dementia admitted to general hospital wards: A longitudinal cohort study. Pain 2015, 156(4): 675–83.CrossRefGoogle ScholarPubMed
Anekar, A.A., and Cascella, M. WHO analgesic ladder. In StatPearls. Treasure Island, FL: StatPearls Publishing, 2021.Google Scholar
Freeman, N., and Clarke, J. Perioperative pain management for hip fracture patients. Orthopaedics and Trauma 2016, 30(2): 145–52.CrossRefGoogle Scholar
Potter, L.J., Doleman, B., and Moppett, I.K. A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips. Anaesthesia 2015, 70: 483500.CrossRefGoogle ScholarPubMed
Patterson, J.J., Bohl, D.D., Basques, B.A., Arzeno, A.H., and Grauer, J.N. Does preoperative pneumonia affect complications of geriatric hip fracture surgery? American Journal of Orthopaedics 2017, 46(3): E177E135.Google Scholar
O’Neil, L., Williams, D.M., Gallagher, M., Price, D.E., and Stephens, J.W. Investigation and treatment of hyponatraemia in hospital patients. Intern MedJ 2018, 48(11): 1416–7. doi: 10.1111/imj.14100. PMID: 30387299.Google ScholarPubMed
Cumming, K., Mckenzie, S., Hoyle, G.E., Hutchinson, J.D., and Soiza, R.L. Prognosis of hyponatraemia in elderly patients with fragility fractures. Journal of Clinical Medicine Research 2015, 7(1): 4551.CrossRefGoogle ScholarPubMed
Kang, J.S., Moon, K.H., Youn, Y.H., Park, J.S., Ko, S.H., and Jeon, Y.S. Factors associated with post-operative acute kidney injury after hip fractures in elderly patients. Journal of Orthopaedic Surgery 2020, 28(1). doi: 10.1177/2309499019896237E.CrossRefGoogle Scholar
Lazarini, V., Mentz, R. J., Fiuzat, M., Metra, M., and O’Connor, C.M. Heart failure in elderly patients: Distinctive features and unresolved issues. European Journal of Heart Failure 2013, 15(7): 717–23.CrossRefGoogle Scholar
Wang, L.H., Xu, D.J., Wei, X.J. et al. Electrolyte disorders and aging: Risk factors for delirium in patients undergoing orthopedic surgeries. BMC Psychiatry 2016, 16(418). doi: 10.1186/s12888-016-1130-0.CrossRefGoogle ScholarPubMed
The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Guidelines for the management of atrial fibrillation. European Heart Journal 2010, 31: 2369–429.Google Scholar
Childers, C.P., Maggard-Gibbons, M., Ulloa, J.G., MacQueen, I.J., Miake-Lye, I.M., Shanman, R., Mak, S., Beroes, J.M., and Shekelle, P.G. Perioperative management of antiplatelet therapy in patients undergoing non-cardiac surgery following coronary stent placement: A systematic review. Systematic Reviews 2018, 7(1): 4.CrossRefGoogle ScholarPubMed
Scottish Intercollegiate Guidelines Network (SIGN). Antithrombotics: indications and Management. Edinburgh: SIGN, 2012.Google Scholar
Dhillon, M., Stock, L., Maisie, G.K., and Mir, A. Appropriate anticoagulation in older adults with atrial fibrillation. Age and Ageing 2018, 47: ii25ii39.Google Scholar
Carnicelli, A. Anticoagulation for valvular heart disease. Journal of the American College of Cardiology 2015, 18 May. www.acc.org/latest-in-cardiology/articles/2015/05/18/09/58/anticoagulation-for-valvular-heart-disease.Google Scholar
Flevas, D.A., Megaloikonomos, P.D., Dimopoulos, L., Mitsiokapa, E., Koulovaris, P., and Mavregenis, A.F. Thromboembolism prophylaxis in ort hopae dics: An update. EFFORT Open Reviews 2018, 3(4): 136–48.Google Scholar
Eichinger, S. Reversing vitamin K antagonists: Making the old new again. Haematology: Education Program 2016, 1: 605–11.Google Scholar
Sikorska, J., and Uprichard, J. Direct oral anticoagulants: A quick guide. European Cardiology Reviews 2017, 12(1): 40–5.CrossRefGoogle Scholar
Chai-Adisaksopha, C., Hillis, C., Siegal, D.M., Movilla, R., Haddle, N., lovio, A., and Crowther, M. Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal: A systematic review and meta-analysis. Thrombosis and Haemostasis 2016, 116(05): 879–90.CrossRefGoogle ScholarPubMed
Leitch, J., and Van Vlymen, J. Managing the perioperative patient on direct oral anticoagulants. Canadian Journal of Anaesthesia 2017, 64(6): 656–72.CrossRefGoogle ScholarPubMed
Desai, N.R., and Cornutt, D. Reversal agents for direct oral anticoagulants: considerations for hospital physicians and intensivists. Hosp Pract (1995) 2019, 47(3): 113–22. doi: 10.1080/21548331.2019.1643728.CrossRefGoogle ScholarPubMed
Keeling, D., Campbell Tate, R., and Watson, H. Perioperative management of anticoagulation and antiplatelet therapy. British Journal of Haematology 2016, 175: 602–13.CrossRefGoogle ScholarPubMed
Rechenmacher, S.J., Fang, J.C. Bridging anticoagulation. Journal of the American College of Cardiology 2015, 66(12): 1392–403.CrossRefGoogle ScholarPubMed
See MHRA guidelines for the perioperative management of patients with implantable pacemakers or implantable cardioverter defibrillators, where the use of surgical diathermy or electrocautery is anticipated. For the perioperative management of patients with implantable pacemakers or ICDs where the use of diathermy is anticipated, see also Thomas, H., Plummer, C., Wright, I.J., Foley, P., and Turley, A.J. Guidelines for the peri-operative management of people with cardiac implantable electronic devices: Guidelines from the British Heart Rhythm Society. Anaesthesia 2022, 77(7): 808–17. doi: 10.1111/anae.15728.CrossRefGoogle ScholarPubMed
Practice Advisory for the Perioperative Management of Patients with Cardiac Implantable Electronic Devices: Pacemakers and Implantable Cardioverter-Defibrillators. An updated report by the American Society of Anaesthesiologists task force on perioperative management of patients with cardiac implantable electronic devices. Anaesthesiology 2011, 114: 247–61.CrossRefGoogle Scholar
Beinart, R., and Nazarian, S. Effects of external electrical and magnetic fields on pace makers and defibrillators: From engineering principles to clinical practice. Circulation 2013, 128: 2799–809.CrossRefGoogle Scholar
Levy, N., Penfold, N.W., and Dhatariya, K. Perioperative management of the patient with diabetes requiring emergency surgery. British Journal of Anaesthesia 2017, 17(4): 129–36.Google Scholar
Cheng-Shyuan, R., Shao-Chun, W., Yi-Chun, C., Peng-Chen, C., Hsiao-Yu, H., Pao-Jen, K., and Ching-hua, H. Stress-induced hyperglycaemia in diabetes: A cross-sectional analysis to explore the definition based on the trauma registry data. International Journal of Environmental Research and Public Health 2017, 14(12): 1527.Google Scholar
Association of Anaesthetists of Great Britain and Ireland. Perioperative management of the surgical patient with diabetes. Anaesthesia 2015, 70: 1427–40.Google Scholar
Pouwels, S., Bagelier, M.T., de Boer, A., Weber, W.E., Neef, C., Cooper, C., and de Vries, F. Risk of fracture in patients with Parkinson’s disease. Osteoporosis International 2013, 24(8): 2283–90.CrossRefGoogle ScholarPubMed
Lisk, R., Watters, H., and Yeong, K. Hip fractures outcomes in patients with Parkinson’s disease. Clinical Medicine 2017, 17(3): s20.CrossRefGoogle Scholar
Coomber, R., Alshameeri, Z., Masia, A.F., Mela, F., and Parker, M.J. Hip fractures and Parkinson’s disease: A case series. Injury 2017, 48(12): 2730–35.CrossRefGoogle ScholarPubMed
Simon, L.V., Hashmi, M.F., and Callanan, A.L. Neuroleptic malignant syndrome. In Stat Pearls. Treasure Island, FL: Stat Pearls Publishing, 2023. www.ncbi.nlm.nih.gov/books/NBK482282.Google Scholar
Chambers, D.J., Sebastian, J., and Ahearn, D.J. Parkinson’s disease. British Journal of Anaesthesia 2017, 17(4): 145–9.Google Scholar
Katzanschlager, R. Apomorphine in the treatment of Parkinson’ s disease. European Neurological Review 2009, 4(1): 2830.CrossRefGoogle Scholar
Brooks, D.J., Calabresi, P., Fox, S., Muller, T., Poevre, W., Rascal, O., and Stocchi, F. Expert perspectives: Parkinson’s disease pathophysiology and management. European Neurological Review 2018, 13 (2): 313.Google Scholar
Brennan, K.A., Genever, R.W. Managing Parkins on’ s disease during surgery. British Medical Journal 2010, 341: c5718.CrossRefGoogle Scholar
Okun, M.S. Subcutaneous apomorphine subcutaneous infusions and Parkinson’s disease. New England Journal of Medicine Journal Watch 2017. www.jwatch.org/na47288/2018/08/22/subcutaneous-apomorphine-infusions.Google Scholar
Spencer, R., and Semmaga, B. Prescribing anti-emetics for patients with Parkinson’s disease. Prescriber 2011: 48–9.CrossRefGoogle Scholar
Leelakonok, N., Hokombo, A., and Schweizer, M.L. Domperidone and risk of ventricular arrhythmias and cardiac death: A systematic review and meta-analysis. Clinical Drug Investigation 2016, 36(2): 97107.CrossRefGoogle Scholar
Anghetescu, D., Cursaru, A., Mihakea, D., Ene, R., Cirstoiu, C. Recent myocardial infarction and femoral neck fixation surgery: A single centre retrospective study. Archives of the Balkan Medical Union 2017, 52(3): 245–8.Google Scholar
Samuel, A.M., Diaz-Collado, P.J., Szolomayer, L.K., Nelson, S.J., Webb, M.L., Lukasiewicz, A.M., and Graver, J.N. Incidence of and risk factors for inpatient stroke after hip fractures in the elderly. Orthopaedics 2018, 41(1): e27e32.CrossRefGoogle ScholarPubMed
Gregerson, M., Borris, L.C., and Damsgaard, E.M. Post-operative blood transfusion strategy in fr ail, anaemic elderly patients with hip fractures: The TRIFE randomized, controlled tiral. Acta Orthopaedica 2015, 86(3): 363–72.Google Scholar
Clevenger, B., and Richards, T. Pre-operative anaemia. Anaesthesia 2015, 70(1): 20–8.CrossRefGoogle ScholarPubMed
Rowlands, M., Forward, D.P., Sahota, O., and Moppeti, I.K. The effect of intravenous iron on post-operative transfusion requirements in hip fracture patients: Study protocol for a randomized, controlled trial. Trials 2013, 14: 288.CrossRefGoogle ScholarPubMed
Pederson, A.B., Ehrenstein, V., Szepligeti, S.K., and Sorensen, H.T. Excess risk of venous thromboembolism in fracture patients and the prognostic impact of comorbidity. Osteoporosis International 2017, 28(12): 3421–30.Google Scholar
Flavus, D.A., Megalokonomos, P.D., Dimopoulos, L., Mitsiokapa, E., Koulovaris, P., and Mavrogenis, A.F. Thromboembolism prophylaxis in orthopaedics: An update. EFFORT Open Reviews 2018, 3(4): 136–48.Google Scholar
Mattison, L., Lapidus, J.L., and Enocson, A. Is fast reversal and early surgery (within 24 hours) in patients on warfarin medication with trochanteric hip fractures safe? A case-control study. BMC Musculoskeletal Disorders 2018, 19: 203.CrossRefGoogle Scholar
Saunders, R., Comerota, A.J., Ozols, A., Tonejon Torres, R., and Ho, K.M. Intermittent pneumatic compression is a cost-effective method of venous thromboembolism prophylaxis. Clinico-Economics and Outcomes Research 2018, 10: 231–41.Google ScholarPubMed
World Health Organization. International Statistical Classification of Diseases and Related Health Problems (ICD). www.who.int/standards/classifications/classification-of-diseases.Google Scholar
Guo, V., Jig, P., Zhang, J., Wang, X., Jieng, H., and Jieng, W. Prevalence and risk factors of operative delirium in elderly hip fracture patients. Journal of International Medical Research 2016, 44(2): 317–27.CrossRefGoogle ScholarPubMed
Wang, C., Qin, V., Wan, X., Song, L., Li, Z., and Li, H. Incidence and risk factors of post-operative delirium in the elderly patients with hip fractures. Journal of Orthopaedic Surgery and Research 2018, 13: 186.CrossRefGoogle Scholar
Krogseth, M., Wyller, T.B., Eugendal, K., and Juliebo, V. Delirium is a risk for institutionalization and functional decline in older hip fracture patients. Journal of Psychosomatic Research 2014, 76(1): 6874.CrossRefGoogle ScholarPubMed
Numan, T., van der Boogard, M., Kamper, A.M., Rood, P.J.T., Peelen, L.M., and Slooter, A.J.C. Recognition of delirium in post-operative elderly patients: A multicenter study. Journal of the American Geriatrics Society 2017, 65(9): 1932–8.CrossRefGoogle ScholarPubMed
Inouye, S.K., and Westendorp, R.G.J., Saczynski, J.S. Delirium in elderly people. Lancet 2014, 383(9920): 911–22.Google ScholarPubMed
American Geriatrics Society Expert Panel on Post-operative Delirium in Older Adults. Post-operative delirium in older adults: Best practice statement from the American Geriatrics Society. Journal of the American College of Surgeons 2015, 220(2): 136–48.Google Scholar
Cunningham, J., and Kim, L.D. Post-operative delirium: A review of diagnosis and treatment strategies. Journal of Xiangya Medicine 2018, 3(2). doi: 10.21037/jxym.2018.0l.03.CrossRefGoogle Scholar
Li, X., Wang, V., Liu, J., Xiong, V., Chen, S., Han, J., Xie, W., & Wu, Q. Effects of periope rative interventions for preventing post-operative delirium: A protocol for systematic review and meta-analysis of randomized controlled trials. Medicine 2021, 100(29). e26662. doi: 10.1097/M D.0000000000026662.CrossRefGoogle Scholar
Neuman, M., Ellenberg, S., Sieber, F., Magaziner, J., Feng, R., and Carson, J. Regional versus general anesthesia for promoting independence after hip fracture (REGAIN): Protocol fora pragmatic, international multicentre trial. BMJ Open 2016, 6.CrossRefGoogle Scholar
Broggi, M.S., Oladeji, P.O., Tahmid, S., Hernandez-Irizarry, R., and Allen, J. Depressive disorders lead to increased complications after geriatric hip fractures. Geriatric Orthopaedic Surgery & Rehabilitation 2021, 12. doi: 10.1177/21514593211016252.CrossRefGoogle ScholarPubMed
Chan, C.K., Staber, F.E., Biennow, K., Inouye, S.K., Khan, G., Leoutsakos, J.S., Marcantonio, E.R., Neufeld, K.J., Rosenberg, P.B., Wang, N., Zetterberg, H., Lyketsos, C.G., and Oh, E. Association of depressive symptoms with post-operative delirium and CSF biomarkers for Alzheimer’s disease among hip fracture patients. American Journal of Geriatric Psychiatry 2021, 29(12): 1212–21. doi: 10.1016/j.jago.2021.02.001.CrossRefGoogle Scholar
Alamo, C., Lopez-Munoz, F., Garcia-Garcia, P., and Garcia-Ramos, S. Risk–benefit analysis of antidepressant drug treatment in the elderly. Psychogeriatrics 2014, 14(4): 261–8. doi: 10.1111/psyg.12057.PMID:25495088.CrossRefGoogle ScholarPubMed
Rundshagen, I. Post-operative cognitive dysfunction. Dtsch Arztebl Int. 2014, 111(8): 119–25. doi: 10.3238/arztebl.2014.0119.Google Scholar
Safavynia, S.A., and Goldstein, P.A. The role of neuroinflammation in post-operative cognitive dysfunction: Moving from hypothesis to treatment. Front. Psychiatry 2019, 9. doi: 10.3389/fpsyt.2018.00752.CrossRefGoogle Scholar
Bell, J.J. et al. Multidisciplinary, multi-modal nutritional care in acute hip fracture inpatients: Results of a pragmatic intervention. Clin Nutr 2014, 33(6): 1101–10.CrossRefGoogle ScholarPubMed
Vaculik, J., Stepan, J.J., DungI., P. et al. Secondary fracture prevention in hip fracture patients requires cooperation from general practitioners. Arch Osteoporos 2017, 12, 49. doi: 10.1007/s11657-017-0346-z.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×