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Chapter 7 - Selection and Design of Industrial Crystallizers

Published online by Cambridge University Press:  14 June 2019

By
Herman J. M. Kramer  and
Richard Lakerveld
Edited by
Allan S. Myerson ,
Deniz Erdemir  and
Alfred Y. Lee
Allan S. Myerson
Affiliation:
Massachusetts Institute of Technology
Deniz Erdemir
Affiliation:
Bristol-Myers Squibb, USA
Alfred Y. Lee
Affiliation:
Merck & Co., Inc
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Summary

Crystallization is one of the most important separation and product-formation technologies in the chemical industry. Typical advantages of crystallization are the low energy consumption, mild process conditions, and high product purity that can be obtained in a single separation step. The future impact of crystallization is even expected to increase further because many new high-added-value products are often in crystalline form. However, future crystalline products are also subject to increasingly stringent product quality requirements related to, for example, flowability, filterability, bioavailability, stability, and dissolution behavior. Product quality requirements for crystalline products typically vary strongly depending on the field of application.

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Chapter
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Handbook of Industrial Crystallization , pp. 197 - 215
Publisher: Cambridge University Press
Print publication year: 2019

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