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This chapter is part of a book that is no longer available to purchase from Cambridge Core

Chapter L

from Drugs: An A–Z Guide

Henry G. W. Paw  and
Rob Shulman
Henry G. W. Paw
Affiliation:
York Hospital, York
Rob Shulman
Affiliation:
University College London Hospitals, London
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Summary

Labetalol is a combined alpha- and beta-adrenoceptor antagonist. The proportion of beta blockade to alpha blockade when given orally is 3:1, and 7:1 when given IV. It lowers the blood pressure by blocking alpha adrenoceptors in arterioles and thereby reduces the peripheral resistance. Concurrent beta blockade protects the heart from reflex sympathetic drive, normally induced by peripheral vasodilatation.

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Handbook of Drugs in Intensive Care
An A-Z Guide
 , pp. 174 - 190
Publisher: Cambridge University Press
Print publication year: 2025

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  • Chapter L
  • Henry G. W. Paw, York Hospital, York, Rob Shulman, University College London Hospitals, London
  • Book: Handbook of Drugs in Intensive Care
  • Online publication: 15 January 2025
  • Chapter DOI: https://doi.org/10.1017/9781009429702.014
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  • Chapter L
  • Henry G. W. Paw, York Hospital, York, Rob Shulman, University College London Hospitals, London
  • Book: Handbook of Drugs in Intensive Care
  • Online publication: 15 January 2025
  • Chapter DOI: https://doi.org/10.1017/9781009429702.014
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter L
  • Henry G. W. Paw, York Hospital, York, Rob Shulman, University College London Hospitals, London
  • Book: Handbook of Drugs in Intensive Care
  • Online publication: 15 January 2025
  • Chapter DOI: https://doi.org/10.1017/9781009429702.014
Available formats
×