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from Drugs: An A–Z Guide
Published online by Cambridge University Press: 15 January 2025
Human normal immunoglobulin is prepared by cold alcohol fractionation of pooled plasma from over 1,000 donations. Individual donor units of plasma are screened for hepatitis B surface antigen (HBsAg) and for the presence of antibodies to human immunodeficiency virus type 1 (HIV-1), HIV-2 or hepatitis C virus (HCV), which, combined with careful donor selection, minimizes the risk of viral transmission. In addition, the testing for HBsAg, HIV-1, HIV-2 and HCV antibodies is repeated on the plasma pools.
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