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4 - Organic thin-film transistors for biological applications

from Part I - Electronic components

Published online by Cambridge University Press:  05 September 2015

By
Katharina Melzer  and
Giuseppe Scarpa
Edited by
Sandro Carrara  and
Krzysztof Iniewski
Katharina Melzer
Affiliation:
Technischen Universität München
Giuseppe Scarpa
Affiliation:
Technischen Universität München
Sandro Carrara
Affiliation:
École Polytechnique Fédérale de Lausanne
Krzysztof Iniewski
Affiliation:
Redlen Technologies Inc., Canada
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Summary

Abstract

In the past few years biosensing concepts based on organic field-effect transistors (OFETs) have attracted more and more attention. Here organic electronics benefit especially from the fact that solution-processable organic thin films can be used in flexible and disposable sensors. Additionally, the outstanding biocompatibility of many organic materials allows the use of organic sensing devices for in-vivo applications and permits the design of biodegradable sensors.

Starting from the basic principles of organic thin-film transistors, this chapter will present the state of the art of biosensing approaches based on OFETs, either back-gated or electrolyte-gated, focusing in particular on different functionalization methods to achieve a selective response of the OFET towards biologically relevant molecules. We present recently published applications of organic thin-film transistors ranging from the detection of biomolecules such as DNA, proteins, and enzymes to the sensing and stimulation of electrical activity potentials of neurons. The sensing mechanism and the influence of the Debye screening length on the detection of biomolecules will be discussed.

Background and introduction

Early and correct diagnosis of diseases plays a crucial role in modern medicine. For several decades researchers have been working on the discovery of biomarkers, molecular indicators giving early information about various diseases. For detection of the increasing number of biomarkers, low-cost, fast, and reliable methods are required.

Type
Chapter
Information
Handbook of Bioelectronics
Directly Interfacing Electronics and Biological Systems
 , pp. 34 - 48
Publisher: Cambridge University Press
Print publication year: 2015

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