This chapter addresses the following questions: Why and how do we need to rethink GM to enable it to master its future? What roles do GM professionals enact to refine their work and to make working abroad more attractive? Overall, this chapter explores the pressures that GM professionals are facing, provides insights into the roles of GM departments and develops a refined GM model. Notwithstanding some of the limitations that diverse contexts, diverging managerial objectives, lacking GM capabilities, and implementation difficulties present, it can be argued that smart, agile, flawless, and efficient GM work (SAFE GM) is at the core of a successful GM department. Smart organisational development and talent management; agile approaches to embrace a multitude of GM challenges successfully; flawless design of programme management and compliance approaches; and efficient ways to structure GM rewards, are leading to a professionalisation of global mobility work. Enacting this SAFE GM framework is likely to strengthen the position of GM departments in their organisation, making their work more strategic, operationally focussed and important.